DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and lim-9

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001300395.1	Gene:	lim-9 / 3565712	WormBaseID:	WBGene00006407	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	629	Identity:	184/629 - (29%)
Similarity:	270/629 - (42%)	Gaps:	141/629 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 QVLEIIEQEEESPEQEA----PKPALPPKQKQQRPVPPLPPPP---------ANRVTQ------- 277
            :|::|.:..|.:..||.    .|.|:...:.::| :..|||||         :|.:.|
Worm    51 EVVDIYDMPENNNAQEKEDHYTKRAIDIGETKKR-LELLPPPPTSSSPRPTSSNSIIQKSDGKRK 114

  Fly   278 DQGTQPAAPQVPLQ-----PLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNEL------- 330
            ||..:..|..:.::     |.:...|..:|            .|::...:.:...|..
Worm   115 DQKNEKQASPIIVEVYDDTPQSKMMLSTMN------------NPYRGGGNNNSNNNNSNHGMVIE 167

  Fly   331 DTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSS 395
            |.:.:||.::...:.|..|........:...|.|                              :
Worm   168 DVTDDPEYSSYGNENEKPENEEEGAFVEYEKLDK------------------------------T 202

  Fly   396 SSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGS----------------- 443
            ...:|....||...:        .|....:.|.::...|.|.|...||
Worm   203 EDPAAFKVCQATTAV--------NRTYNNIRPSYRMPIGGGSGSSSGSISREIRIESMNLTDVED 259

  Fly   444 GAAAGPP---LGPQYSP------GCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGG 499
            ||.....   ||.:..|      .|.::  .|:.:|||        :.||:..:... :..|||.
Worm   260 GARCRDKECHLGWKQHPWRKVCVHCKSD--RSDHELPP--------NQALNVYNRLG-IQPPAGM 313

  Fly   500 TSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSP 564
            ..|..|.      |.:           .|.....|.||||||...:|..|.||:|::.||..||.
Worm   314 PQSGVAE------PEV-----------PGSVGHGYAWVPPGLSRKKVEEYMSQLPNNVVPRTNSN 361

  Fly   565 GEQYRVRQLLHQLPPHDNEVRYCHSLTDE-ERKELRLFSTQRKRDALGRGNV-RQLMSARPCDGC 627
            ||:.|.:|||.|||..|..|.||..||.: |||....|...|...||..|.| ..:..|..|..|
Worm   362 GEKLREKQLLLQLPRQDLSVAYCRHLTSQTERKVYEEFVNARNEIALDIGYVSSNINKAMECHKC 426

  Fly   628 DDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSAC 692
            ..::.|.::||.|.:||.:..||||||.|..|.:|||||.|..:|.::||.||:||..|||||||
Worm   427 SGILETNEMAVIAPKLGDSTGWHPACFTCQACEQLLVDLTYCVKDNQIYCERHYAELHKPRCSAC 491

  Fly   693 DEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIG 757
            ||:|.|.|.|:|..:.||.:||.|.:||:.|.|||||||:.:|||:.|::.:||..||.|.:.||
Worm   492 DELIFAGEYTKAMNKDWHSDHFCCWQCDQTLTGQRYIMRDEQPYCIKCYEDVFANQCDECAKPIG 556

  Fly   758 VDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCS 801
            :|...:|:..:|||  :.||.|:.|:.||:...|..:...|:||
Worm   557 IDSKDLSYKDKHWH--EHCFLCSMCKISLVDMPFGSKNDRIFCS 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	41/96 (43%)
		LIM1_Prickle	624..682	CDD:188799	27/57 (47%)
		LIM2_Prickle	687..742	CDD:188802	32/54 (59%)
		LIM3_Prickle	747..805	CDD:188804	20/55 (36%)
lim-9	NP_001300395.1	PET_LIMPETin_LIM-9	329..412	CDD:193605	38/82 (46%)
		LIM1_LIMPETin	423..480	CDD:188798	26/56 (46%)
		LIM2_Testin_like	486..541	CDD:188727	32/54 (59%)
		LIM3_LIMPETin	544..602	CDD:188805	22/57 (39%)
		LIM4_LIMPETin	609..662	CDD:188809
		LIM5_LIMPETin	670..721	CDD:188814
		LIM6_LIMPETin	729..784	CDD:188816
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I5607
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910