DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and jub

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	167/832 - (20%)
Similarity:	276/832 - (33%)	Gaps:	248/832 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QRLADANQEPDNARDREYDTVDCDLIAGQLDAVEDADDGIDLGDHSSTPKGGATTAGRPLFPHSS 144
            ||.....:.|.|: |.:|:|:...|..|       ...|..:|....:  ||....|..:..:..
  Fly     4 QRTQTQARNPGNS-DSDYETLMQRLHIG-------GGGGAGVGGGGGS--GGPGDGGVAMRSYQR 58

  Fly   145 SPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVTQRNARVTVLDDPFLFGIDADHLGDLVVRG 209
            ||...:..|:..:...:..::.:......|:..::.:|                    |:::...
  Fly    59 SPGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKLYER--------------------GNIIAAS 103

  Fly   210 KRYST------LDATEN-MARFYAEQEATAQVL-EIIEQEEESPEQE----------APKPALP- 255
            | |:|      :..|.| .|:.||   .|||:| :.|..::.||..|          ..|.|.|
  Fly   104 K-YATPRPVEQIQHTHNGSAQIYA---PTAQILGQRIAPQKHSPVYENLEFYGQFDSNHKRAQPQ 164

  Fly   256 -PKQKQ---------QRPVP----PLPPPPANRVTQDQGTQPAA--PQVP------LQPLTAGDL 298
             |..:|         .:|:.    ...|.|.|:.:...||..||  |..|      |.|  .|||
  Fly   165 SPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGGPPPPSGRSAALGP--TGDL 227

  Fly   299 QFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQ 363
            :.....:.:..:|.|.:             .....|.|..||...:.:.....|.:..|....|.
  Fly   228 EEHAAPIYENIIPHSGQ-------------RAQPQASPATATMYQEMQPTSNSSGSSSTAGLDLN 279

  Fly   364 KIPTLPRHFSPSGQGLATPPALGS-----GGMGLPSSSSASALYAAQAAAGILPTSPLPLQRHQQ 423
            .:...|.|........|:..:|||     ..:.||  |..|.:..||:.|.:           ||
  Fly   280 ALLASPMHQRSISSNTASSSSLGSPTQRYRNLSLP--SHLSPVPTAQSVAKL-----------QQ 331

  Fly   424 YLP-------------PHHQQ--------------HPGAGMGPGPGSGAAAGPPLGPQYSPGCSA 461
            :.|             |::.:              |.....|...|..||.|.|
  Fly   332 HTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAP----------- 385

  Fly   462 NPKYSNAQLPPPPHHHHQLSPALSTPSPP-------SLLHHPAGGTSSASAHA-PFLGGPHMDMQ 518
                :...:..||.....|:..::|.:||       |....||..||:||..| |......:.:.
  Fly   386 ----AQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLAVA 446

  Fly   519 RQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGE-------QYRVRQLLHQ 576
            ........|       |.|...|:|.:      .:..:.:||..:|..       |.::.:|..|
  Fly   447 TSPTPSQGS-------TAVNAALKPRR------GLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQ 498

  Fly   577 L-------PPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTG 634
            |       ..|......||:..::.:               |.|...|.|              |
  Fly   499 LEEEIEQSEEHGEYFGICHTCGEKVK---------------GAGQACQAM--------------G 534

  Fly   635 DIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHA----ETLKPRCSACDEI 695
            ::            :|..||.|..|...|....:::..||:||...:.    :....:|:.|..:
  Fly   535 NL------------YHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHL 587

  Fly   696 ILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMR-EGKPYCLHCFDAMFAEYCDYCGEAI--- 756
            |: :...:|.|:::|...|.|..|::.|.|..:.:. :.|.||::.:..|||..|..||:.|
  Fly   588 IM-EMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPV 651

  Fly   757 -GVDQG----QMSHDGQHWHATDECFSCNTCRCSLL---GRAFLPRRGAIYC 800
             |.|:.    .|..|   :|.  :|:.|..|...|.   .:...|..|.:.|
  Fly   652 EGTDETVRVVSMDKD---FHV--DCYICEECGMQLTDEPDKRCYPLDGRLLC 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	17/108 (16%)
		LIM1_Prickle	624..682	CDD:188799	11/57 (19%)
		LIM2_Prickle	687..742	CDD:188802	14/55 (25%)
		LIM3_Prickle	747..805	CDD:188804	16/65 (25%)
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	17/93 (18%)
		LIM2_Ajuba_like	581..633	CDD:188741	14/52 (27%)
		LIM3_Ajuba_like	641..702	CDD:188822	16/63 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810