DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Prickle1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_955428.1	Gene:	Prickle1 / 315259	RGDID:	735090	Length:	831	Species:	Rattus norvegicus

Alignment Length:	931	Identity:	312/931 - (33%)
Similarity:	428/931 - (45%)	Gaps:	265/931 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 QRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDN 582
            ||.|.||||||||||||.||||||||:|::|||:.:|::||||||||||::|::|||:|||||||
  Rat    17 QRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDN 81

  Fly   583 EVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATRLG 644
            |||||.||::||:|||::||.|||::|||||.::.|   |....|:.|...::.|::||||:|.|
  Rat    82 EVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAG 146

  Fly   645 PNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAW 709
            |...|||:||.|..|.|||||||||::||:::|||||||.||||||||||||.||||||||||.|
  Rat   147 PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHW 211

  Fly   710 HMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATD 774
            ||.||.|.||:..||||||||::|:|:|..||::::||||:.|||.||||..||::||||||||:
  Rat   212 HMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE 276

  Fly   775 ECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQR--------- 830
            .||||..|:.||||..|||::|.||||..||.||....||||.:...:..:..::|
  Rat   277 ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSR 341

  Fly   831 ----------VRPHPQAPLP---------------------------------ARIPSSHASSSP 852
                      :.|......|                                 ||: ...||..|
  Rat   342 SADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDVSLSGQGAGFAHEEFWKARV-DQEASEDP 405

  Fly   853 -------------------------PMS-------------------PQQQQQHQA----TFNQA 869
                                     |.|                   |:.:|.||:    .:...
  Rat   406 EEWAEHEDYMTQLLLKFGDKNLFQQPPSEVDMRASEHWIPDNMVTNKPEAKQNHQSLASKKYQSD 470

  Fly   870 MYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVK----DLEHGGHMGGGDLTDFSGGRASSTSQNL 930
            ||..|||.     ||.|  .:|.:....|...:    ||:||......|.|.:    ...:.:.|
  Rat   471 MYWAQSQD-----GLGD--SAYGSHPGPASSRRLQELDLDHGAAGYNHDQTQW----YEDSLECL 524

  Fly   931 SPLNSPGDFQPHFLPKPMELQRDGVYNF---NEMSSNLDAAWSAKPTNS-YHLQRQLLENPHTAS 991
            |.|            ||.:..||.:.:.   |...:::|.  .:||..| |.||          :
  Rat   525 SDL------------KPEQSVRDSMDSLALSNITGASVDG--ESKPRPSLYSLQ----------N 565

  Fly   992 MPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPP 1056
            ..|:..:      ..:.:|.:..::|...  |..|:             .|.:.|..:....:.|
  Rat   566 FEEIEAE------DCEKMSNMGTLNSSML--HRSAE-------------SLKSLNSELCPEKIIP 609

  Fly  1057 ELMGSPTHSAGDRSLNTPMSTQSASHAPPHPV----SILSGAS-----SSSPMSGEPAKKKGVRF 1112
            |          ::.::.|:..:|.|.:.|..|    .::...|     ...|||
  Rat   610 E----------EKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMS----------- 653

  Fly  1113 EGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRRRRRRKSSSSSSHHRSGS 1177
                                    ||.|.|....|..|...|.|  |.||.|||.|.::.:.  .
  Rat   654 ------------------------ERTRRRVYHFEERGSRPHHH--RHRRSRKSRSDNALNL--V 690

  Fly  1178 GHRSHST-TRADTYAP-----------AQPLSSSYQGPPSVLQAANL----VHESP--SRQQRER 1224
            ..|.:|. .|...|.|           |:.|.       :.:|.|||    .|.:.  :.|....
  Rat   691 TERKYSAKDRLRLYTPDNYEKFIQSKGARELQ-------AYMQNANLYGQYAHTTSDYALQNPGM 748

  Fly  1225 EREREREESEESDVCSTCSSSSSSSED-YMMMYQLPQRRHYGGVRVSYVPNDALA---------- 1278
            .|.......::...||:.:|||.|.|: |.:...:||.|..   |.:|..:|..:
  Rat   749 TRFLGLYGDDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQ---RFTYYTDDLSSPASALPTPQF 810

  Fly  1279 YDRKRKPSELGGDKDKNCIIS 1299
            ..|..|..:..|.:.||||||
  Rat   811 NQRTTKSKKKKGHRGKNCIIS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	68/94 (72%)
		LIM1_Prickle	624..682	CDD:188799	32/57 (56%)
		LIM2_Prickle	687..742	CDD:188802	40/54 (74%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
Prickle1	NP_955428.1	PET_Prickle	22..118	CDD:193602	68/95 (72%)
		LIM1_Prickle_1	126..184	CDD:188867	32/57 (56%)
		LIM2_Prickle	189..244	CDD:188802	40/54 (74%)
		LIM3_Prickle	249..307	CDD:188804	37/57 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..346		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..688		11/25 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831		21/70 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4300
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm9129
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830