DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and Prickle2

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_038963548.1	Gene:	Prickle2 / 312563	RGDID:	1306723	Length:	939	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	352/1048 - (33%)
Similarity:	463/1048 - (44%)	Gaps:	261/1048 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 SSSSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYS-- 456
            |..|.|.|:.:.||      .|:|....|:               |||.....|...|.||.:
  Rat    11 SRRSVSVLHPSGAA------RPVPTASSQR---------------PGPAPLRPAAAHLWPQLTGL 54

  Fly   457 ----------------PGCSANPKYSNAQLP---PPPHHHHQLSPALSTPSPPSLLHHPAGGTSS 502
                            ||.:.: |:....|.   |...|...:.|.....:...|:
  Rat    55 GRIERGQPCNACGDQCPGFALH-KWRKICLHCKCPQEEHMVTVMPLEMEKTISKLM--------- 109

  Fly   503 ASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQ 567
                        .|.||.|.||||||||||||.||||||:|:||..|:|.:|::||||||||||:
  Rat   110 ------------FDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEK 162

  Fly   568 YRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDD 629
            .|::||||||||||||||||:||.:||::||:|||.||||:.|||||||..   |:...|:.|..
  Rat   163 LRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGG 227

  Fly   630 LISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDE 694
            .|..|||||||:|.|....|||.||.|:||.|||||||||::||::||||||||.|||||:||||
  Rat   228 QIKGGDIAVFASRAGHGICWHPPCFICTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDE 292

  Fly   695 IILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVD 759
            ||.||||||||||.|||.||.|.||:..||||||||:||:|||.|||::::|||||.|.:.||:|
  Rat   293 IIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGID 357

  Fly   760 QGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTP 824
            ||||::||||||||:.||.|..|:.|||||.|||::|.|:||.|||.||.|..||||.:......
  Rat   358 QGQMTYDGQHWHATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNAR 422

  Fly   825 TPPTQR---------------VRPHPQA------------PLPARIPSSHASSSPPMSPQ----Q 858
            ...::|               :..|.|.            ||..::.....||..|...:    :
  Rat   423 AKESRRSAKIGKNKGKTEETMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRDPIWR 487

  Fly   859 QQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGVVKDL-----------------EH 906
            .:.....:...|.|.|||.........:...||:.....||...|:                 .|
  Rat   488 SRDEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQAAGAQPDMWAKHFSNPKRSSSMALKGH 552

  Fly   907 GGHMGGGDLTDFSGGRASS-------TSQNLSPLNSPGDFQ-PHFLPKPMELQRDGVYNFNEMSS 963
            ||........|:..||..|       :||:.|  .:.|... |.:..:..|.:.:|..:..:...
  Rat   553 GGSFIQECREDYYPGRLMSQESYSDMSSQSFS--ETRGSIPVPKYEEEEEEEEEEGGISTQQCRP 615

  Fly   964 NLDAAWSAKPTNSYHLQRQLLENPHT--ASMPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYA 1026
            .       :|.:|......:.....|  .||..||         :.:.:.|.|....:.|:|
  Rat   616 R-------RPLSSLKYTEDMTPTEQTPRGSMESLA---------LSNATGLSAEGGAKRQEH--- 661

  Fly  1027 DILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSLNTPMSTQSASHAPPHPVSIL 1091
                        :.....|:||..|.....|.:.:.      .:||:.|..:||     ..|..|
  Rat   662 ------------LSRFSMPDLSKDSGMNVSEKLSNM------GTLNSSMQFRSA-----ESVRSL 703

  Fly  1092 SGASSSSPMSG------EPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGG 1150
            ..|.....|.|      .|...:.::..|   .:.:|..:.|..|.:...|:.           |
  Rat   704 LSAQQYQEMEGNLHQLSNPLGYRDLQSHG---RMHQSFDFDGGIASSKLPGQE-----------G 754

  Fly  1151 RHGHGHSSRRRRRRKSSSSSSH---HRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANL 1212
            .|....|.|.|||..|...:..   |||....||.|..       |..|:|..:      ..|.|
  Rat   755 VHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDN-------ALHLASERE------VIARL 806

  Fly  1213 VHESPSRQQRERE---REREREES----------------------------------EESDVCS 1240
            ....|.|.:.:.:   |:|..:||                                  .|.|.||
  Rat   807 KDRPPLRAREDYDQFVRQRSFQESMGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCS 871

  Fly  1241 TCSSSS-SSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYDRKR----KPSELGG---------D 1291
            |||||| |.:|.|.:...:||     ..|:.||.:|.|.:....    |.|.|||         .
  Rat   872 TCSSSSESDNEGYFLGEPIPQ-----PARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQ 931

  Fly  1292 KDKNCIIS 1299
            |.||||||
  Rat   932 KSKNCIIS 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	71/94 (76%)
		LIM1_Prickle	624..682	CDD:188799	36/57 (63%)
		LIM2_Prickle	687..742	CDD:188802	42/54 (78%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
Prickle2	XP_038963548.1	PET_Prickle	118..214	CDD:193602	71/95 (75%)
		LIM1_Prickle	222..280	CDD:188799	36/57 (63%)
		LIM2_Prickle	285..340	CDD:188802	42/54 (78%)
		LIM3_Prickle	345..403	CDD:188804	37/57 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345861
Domainoid	1	1.000	149	1.000	Domainoid score	I4300
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm9129
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760