DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and Limd1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_038888.2	Gene:	Limd1 / 29806	MGIID:	1352502	Length:	668	Species:	Mus musculus

Alignment Length:	756	Identity:	161/756 - (21%)
Similarity:	246/756 - (32%)	Gaps:	238/756 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 DHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQE------APKPALPPKQ 258
            |...||.:...::     .|::..:.|.::.   :..:.:....:||.|      |.|.|....|
Mouse     2 DKYDDLGLEASKF-----IEDLNMYEASKDG---LFRVDKGAGNNPEFEETRRVFATKMAKIHLQ 58

  Fly   259 KQQRPVPPLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDI 323
            :||:          .::.|::    |.|:....|:..|:.|..:..|   :...:.||
Mouse    59 QQQQ----------QQLLQEE----ALPRAGRSPVNGGNRQGASGKL---AADGAAKP------- 99

  Fly   324 SFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSG 388
                    ..|.|.||.|.|        :.|...|.||    |:..:...||..| |.|.:...|
Mouse   100 --------PLAVPTVAPGLA--------TTTAAAQPSY----PSQEQRIRPSAHG-ARPGSQNCG 143

  Fly   389 GMGLPSSSSASALYAAQAAAGILPTSPLP-LQRHQQYLPPHHQQHPGAGMGP--------GPGSG 444
            ....|.||...||:      |:.|:...| ...|..|........|..|..|        |.|||
Mouse   144 SREGPVSSQRPALH------GLSPSCEDPSCLTHGDYYDNFSLASPQWGDKPEGCPSVSLGVGSG 202

  Fly   445 AAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLL---------------- 493
                       .|||..|    ::.||.....||...|.|||.......
Mouse   203 -----------WPGCPGN----DSTLPKSCGDHHPYQPQLSTVCSGRSFESGISGQDGGIGGHSS 252

  Fly   494 HHPAGGTSSASAHAPFLGGPHMDMQRQSHSDD----------------------DSGCALEEYTW 536
            ..|.|..|:||:....||...|.::..:.:..                      |||...|....
Mouse   253 EKPTGLWSTASSQRVNLGFSSMGLENGTSAQPKGTTVSAPMVPSSASQGACPKRDSGLGYEASGR 317

  Fly   537 V-------PPGLRPDQVRLYFS------------------------------------QIPDDKV 558
            |       .|.|: |..:.|.|                                    ..|...|
Mouse   318 VFKPLVDTQPWLQ-DGPKSYLSVSAPLSSTAGKDSTQPGMTTGLDPKFGCVESGTSPKPSPTSNV 381

  Fly   559 -PYVNSPGE--------QYRVRQLLHQ-LP--PHDNEVRY-CHSLTDEERKELRLFSTQRKRDAL 610
             |.:::|.|        .:.....|.. ||  |..:.||. |.:|.  ...||...:.:.|.:||
Mouse   382 HPVMSTPSELSCKESSPSWSTDSSLEPVLPGSPTPSRVRLPCQTLA--PGPELGPSTAELKLEAL 444

  Fly   611 GRGNVRQLMSARP-------CDGCDDLI--------STGDIAVFATRLGPNASWHPACFACSVCR 660
            .:...|: |.|.|       |..|...:        :.||:            :|.|||.|:.|.
Mouse   445 TQRLERE-MDAHPKADYFGSCVKCSKGVFGAGQACQAMGDL------------YHDACFTCAACS 496

  Fly   661 ELLVDLIYFHRDGRMYCGRHHA----ETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDK 721
            ..|....::..:|:::|.....    :....||..|..:|: |...:|.|:::|...|.|..|::
Mouse   497 RKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIM-DMILQALGKSYHPGCFRCVICNE 560

  Fly   722 QLGGQRY-IMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQ------MSHDGQHWHATDECFSC 779
            .|.|..: :..|.|.||:..:..:.|..|..||..|...:|.      :|.| :.:|.  ||:.|
Mouse   561 CLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMD-RDYHV--ECYHC 622

  Fly   780 NTCRCSLL---GRAFLPRRGAIYCSIAC-----SKGEPPTP 812
            ..|...|.   |....|....::|. :|     .||..|.|
Mouse   623 EDCGLELNDEDGHRCYPLEDHLFCH-SCHVKRLEKGPSPAP 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	29/172 (17%)
		LIM1_Prickle	624..682	CDD:188799	13/65 (20%)
		LIM2_Prickle	687..742	CDD:188802	17/55 (31%)
		LIM3_Prickle	747..805	CDD:188804	17/71 (24%)
Limd1	NP_038888.2	Mediates nuclear export. /evidence=ECO:0000250	54..128		23/117 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..160		29/122 (24%)
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	181..256		19/89 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..309		1/31 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..414		8/73 (11%)
		Interaction with RB1. /evidence=ECO:0000250	396..434		10/39 (26%)
		Necessary for nuclear localization. /evidence=ECO:0000250	464..668		52/216 (24%)
		LIM1_Ajuba_like	464..517	CDD:188738	13/64 (20%)
		LIM2_Ajuba_like	529..581	CDD:188741	16/52 (31%)
		LIM3_Ajuba_like	589..650	CDD:188822	16/64 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810