Protein Alignment pk and Prickle2

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: NP_001391015.1
• Gene: Prickle2 / 243548
• MGIID: 1925144
• Length: 937
• Species: Mus musculus
• Alignment Length: 1031
• Identity: 358/1031 - (34%)
• Similarity: 472/1031 - (45%)
• Gaps: 229/1031 - (22%)

  Fly   394 SSSSASALYAAQAA-----AGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPP--- 450
            |..|.|.|:.:.||     ||.....|.||.....:|.|   |..|.|.       ...|.|
Mouse    11 SRRSVSVLHPSGAARPVPTAGSQRPGPAPLHPAAAHLWP---QLTGLGR-------IERGQPCNA 65

  Fly   451 LGPQYSPGCSANPKYSNAQLP---PPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGG 512
            .|.| .||.:.: |:....|.   |...|...:.|.....:...|:
Mouse    66 CGDQ-CPGFALH-KWRKICLHCKCPQEEHMVTVMPLEMEKTISKLM------------------- 109

  Fly   513 PHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQL 577
              .|.||.|.||||||||||||.||||||:|:||..|:|.:|::|||||||.||:.|::||||||
Mouse   110 --FDFQRSSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSAGEKLRIKQLLHQL 172

  Fly   578 PPHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVF 639
            ||||||||||:||.:||::||:|||.||||:.|||||||..   |:...|:.|...|..||||||
Mouse   173 PPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVF 237

  Fly   640 ATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEA 704
            |:|.|....|||.||.|:||.|||||||||::||::||||||||.|||||:||||||.|||||||
Mouse   238 ASRAGHGICWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEA 302

  Fly   705 EGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQH 769
            |||.|||.||.|.||:..||||||||:||:|||.|||::::|||||.|.:.||:|||||::||||
Mouse   303 EGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQH 367

  Fly   770 WHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPH 834
            ||||:.||.|..|:.|||||.|||::|.|:||.|||.||.|..||||.:.........::|
Mouse   368 WHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRR---- 428

  Fly   835 PQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQ--SQQMEAAGGLVDQSKSYAASDSD 897
                 .|:|..:...:...|. .|..|.|.:.|:....:.  |.||:    |:..|....:.:.|
Mouse   429 -----SAKIGKNKGKTEEAML-NQHSQLQVSSNRLSADVDPLSVQMD----LLSLSSQTPSLNRD 483

  Fly   898 AGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLN-----SPG----DFQP-----HFL-PK- 946
            . :.:..|...|.|    ......::.|..|.||..|     |||    ..||     ||. ||
Mouse   484 P-IWRSREEPFHYG----NKMEQNQSQSPLQLLSQCNIRTSYSPGGQGAGAQPDMWAKHFSNPKR 543

  Fly   947 --PMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPH----TASMPELAGKLVAPPAH 1005
              .|.|:..|            .::..:....|:..|.:.:..:    :.|..|..|.:..|...
Mouse   544 SSSMALKGHG------------GSFIQECREDYYPGRLMSQESYSDMSSQSFNETRGSIPVPKYE 596

  Fly  1006 MQHLSQLHAVSSHQFQQH------EYADILHPPPPPP-GEIPELPTPN---LSVASTA------- 1053
            .:...:...:|:.|.:..      :|.:.:.|....| |.:..|...|   ||....|
Mouse   597 EEEEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLS 661

  Fly  1054 --LPPELMGSPTHSAGDR-----SLNTPMSTQSASHAPPHPVSILSGASSSSPMSG------EPA 1105
              ..|:|......:..::     :||:.|..:||     ..|..|..|.....|.|      .|.
Mouse   662 RFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSA-----ESVRSLLSAQQYQEMEGNLHQLSNPL 721

  Fly  1106 KKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSRRRRRRKSSSSS 1170
            ..:.::..|   .:.:|..:.|..|.:...|:.           |.|....|.|.|||..|...:
Mouse   722 GYRDLQSHG---RMHQSFDFDGGIASSKLPGQE-----------GVHIQPMSERTRRRTTSRDDN 772

  Fly  1171 SH---HRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQRERE------R 1226
            ..   |||....||.|.......:..:.::...:.||                .|.||      |
Mouse   773 RRFRPHRSRRSRRSRSDNALHLASEREVIARLKERPP----------------LRAREDYDQFMR 821

  Fly  1227 EREREES----------------------------------EESDVCSTCSSSS-SSSEDYMMMY 1256
            :|..:||                                  .|.|.|||||||| |.:|.|.:..
Mouse   822 QRSFQESLGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNEGYFLGE 886

  Fly  1257 QLPQRRHYGGVRVSYVPNDALAYDRKR----KPSELGG---------DKDKNCIIS 1299
            .:||     ..|:.||.:|.|.:....    |.|.|||         .|.||||||
Mouse   887 PIPQ-----PARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	70/94 (74%)
		LIM1_Prickle	624..682	CDD:188799	36/57 (63%)
		LIM2_Prickle	687..742	CDD:188802	42/54 (78%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
Prickle2	NP_001391015.1	PET_Prickle	118..214	CDD:193602	70/95 (74%)
		LIM1_Prickle	222..280	CDD:188799	36/57 (63%)
		LIM2_Prickle	285..340	CDD:188802	42/54 (78%)
		LIM3_Prickle	345..403	CDD:188804	37/57 (65%)