DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and LIMCH1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_011511944.1	Gene:	LIMCH1 / 22998	HGNCID:	29191	Length:	1655	Species:	Homo sapiens

Alignment Length:	1416	Identity:	248/1416 - (17%)
Similarity:	391/1416 - (27%)	Gaps:	540/1416 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ADANQEPDNARDREYDTVDC-----------DLI-AGQLDAVEDADDGIDLGDHSSTP------- 128
            :|:...|.:.||..:|::|.           |:: .|..|. ..:|...|| .|...|
Human   188 SDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDG-RGSDSESDL-PHRKLPDVKKDDM 250

  Fly   129 KGGATTAGRP--------LFPHSS-------SPRRSKKLLR--------SLRAHVRGEKLPKNDT 170
            ....|:.|.|        ..|:.|       :|.|.||..|        :..:.:.||:......
Human   251 SARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWSTATSPLGGERPFSFPE 315

  Fly   171 TTANESSEVTQRNARVTVLDDP----------------FLFGIDADHL---GDLVVRGKRYSTLD 216
            |...|.|||.....     |:|                ...|...:|.   |.:|....:....|
Human   316 TIEEEGSEVGSAGE-----DNPAGQMNPGWKPSDGGCELPDGSGKEHPSSDGAVVAPAPKSEEKD 375

  Fly   217 ATENMARFYAEQEATAQVL----EIIEQEEESPEQEAPKPALPPKQK-------------QQRPV 264
            |.|...|...|| |..:|:    ....|::.|.|:||.:..:..|:.             :...|
Human   376 AAEIQKRKRLEQ-AGIKVMPAAQRFASQKQLSEEKEAIRDIVLRKENSFLTHQHGNDSEAEGEVV 439

  Fly   265 PPLPPP-----PANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDIS 324
            ..||..     .|.|...:|    ..|.|||..|..|............|...| |.......:.
Human   440 CRLPDLEKDDFAARRARMNQ----TKPMVPLNQLLYGPYPKKGAEKSDGSKQLS-KGISKKRSLE 499

  Fly   325 FTFNELDTSAEPEVATGAAQQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGG 389
            :..|:..|.....:.|...:.:.:||:.       ..|:|:|.|.:
Human   500 YKRNQGHTEEVKLIVTCNMRAQESEPVE-------GGLRKVPDLHK------------------- 538

  Fly   390 MGLPSSSSASALYAAQAAAGILPTSPLPLQRHQQYLPPHHQ------------------------ 430
                                    ..|..||.|..|.||.:
Human   539 ------------------------DDLAQQRIQGSLAPHREPPSFITLSNITEADLETWERLKVS 579

  Fly   431 --------QHPGAGMGPGP------------------GSGAAAGP-----PLGP----------Q 454
                    ||..|. .|.|                  .|..|:.|     ..||          :
Human   580 EKARDGDVQHICAS-EPSPEIKAETAIRDDFANRKARASKKASSPRQKFVHFGPVTELDQQKWKR 643

  Fly   455 YSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQR 519
            .|.| .|.|:....::     ..|.....:.:.||.|      ..|||...|..|        .|
Human   644 LSIG-KAGPREDEEEV-----ICHGSKIQMDSVSPVS------AATSSLKGHQIF--------NR 688

  Fly   520 QSHSDDDSGCALEEY----TWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYR-VRQLLHQLPP 579
            |:.. ....|...:|    :|:.|             :|:.:..:|.|.||..| ..::..:..|
Human   689 QNDC-RTMNCGRGDYCRRASWLAP-------------VPESQEEWVCSLGECPRGTEEVTSKQLP 739

  Fly   580 HDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLG 644
            .|.:.....:..|.|    ||...:|..|           |::|.
Human   740 QDGKEETESAPRDSE----RLSKAERSED-----------SSQPL-------------------- 769

  Fly   645 PNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAW 709
                         ||                           |..|.|:.....::..:....||
Human   770 -------------VC---------------------------PLASECEASGTEEKLEKMTAPAW 794

  Fly   710 HMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATD 774
                     ....|.|||.:....|       |.|.|       ...|:   .:.|.|.:
Human   795 ---------SGSGLKGQRKLDDSRK-------DDMMA-------RRTGM---SLRHTGSN----- 828

  Fly   775 ECFSCNTCRCSLLGRAFLPRRGAIYCSI-ACSKGEP----------PTPSDSSGTGMYTTPTPPT 828
                         ...|||...|....: ..|||.|          |...|:..|.|:.......
Human   829 -------------PNQFLPVPFAKQQDVEESSKGLPMKDQRYGPRTPVSDDAESTSMFDMRCEEE 880

  Fly   829 QRVRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAA 893
            ..|:||.:|                    :|:|.|...||...:....|.:.|     :.||...
Human   881 AAVQPHSRA--------------------RQEQLQLINNQLREEDDKWQDDLA-----RWKSRRR 920

  Fly   894 SDSDAGVVKDLEHGGH---MGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGV 955
            |.|...:.|:.|....   :.|.|          .||:....:.:..:.......:..||
Human   921 SVSQDLIKKEEERKKMEKLLAGED----------GTSERRKSIKTYREIVQEKERREREL----- 970

  Fly   956 YNFNEMSSNLDAAWSAKPTNSYHLQR--------------QLLENPHTASMPELAGKLVAPPAHM 1006
               :|...|..:...|:.....:::|              ::||..|:.. |.|: ..:..|..|
Human   971 ---HEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTE-PNLS-SFLNDPNPM 1030

  Fly  1007 QHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSL 1071
            ::|.|...                 |||......|......||..|::... .|||:.:...:::
Human  1031 KYLRQQSL-----------------PPPKFTATVETTIARASVLDTSMSAG-SGSPSKTVTPKAV 1077

  Fly  1072 NTPMSTQSASHAPPHPVSILSGASSSSPMS--GE----------------PAKK--KGVRFEGI- 1115
              ||.|......|.:...:|........:|  ||                ||..  |...|||:
Human  1078 --PMLTPKPYSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVA 1140

  Fly  1116 ----------------------PDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSS 1158
                                  |:::|:..      |.|:  .:.|.:..:||..||:      |
Human  1141 RVHGSPLELKQDNGSIEINIKKPNSVPQEL------AATT--EKTEPNSQEDKNDGGK------S 1191

  Fly  1159 RRRRRRKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQRE 1223
            |:.....:||...|.          ||.....:|    :.::...||..|..|.|.|...:::.|
Human  1192 RKGNIELASSEPQHF----------TTTVTRCSP----TVAFVEFPSSPQLKNDVSEEKDQKKPE 1242

  Fly  1224 REREREREESEESDVCSTCSSSSSSSEDYMMMYQLPQRRHYGGVRVSYVPN 1274
            .|...:.|......|....|....::..:..:.::|:....      ::||
Human  1243 NEMSGKVELVLSQKVVKPKSPEPEATLTFPFLDKMPEANQL------HLPN 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	18/99 (18%)
		LIM1_Prickle	624..682	CDD:188799	2/57 (4%)
		LIM2_Prickle	687..742	CDD:188802	10/54 (19%)
		LIM3_Prickle	747..805	CDD:188804	7/58 (12%)
LIMCH1	XP_011511944.1	CH	26..138	CDD:237981
		DUF4757	250..>311	CDD:292571	12/60 (20%)
		DUF4757	813..961	CDD:292571	38/210 (18%)
		GBP_C	<1340..1377	CDD:303769
		LIM	1585..1642	CDD:214528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900