DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and FHL3

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_004459.2	Gene:	FHL3 / 2275	HGNCID:	3704	Length:	280	Species:	Homo sapiens

Alignment Length:	263	Identity:	74/263 - (28%)
Similarity:	105/263 - (39%)	Gaps:	56/263 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 QLPPHDN-----EVRYCH-----------SLTDE----ERKEL-------RLFSTQRKRDALGRG 613
            ||..||:     |.|:.|           ||.||    :..||       ..||:|
Human    45 QLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQ--------- 100

  Fly   614 NVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCG 678
                      |..|.:.:..|...:   ..| ..:||..||.||.|.:.|....:....|..||.
Human   101 ----------CSACGETVMPGSRKL---EYG-GQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCV 151

  Fly   679 RHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDA 743
            ..:.....|||:.|.:.:.....|..: :.||.....|..|...|.||::..|:..|||:.||..
Human   152 PCYENKFAPRCARCSKTLTQGGVTYRD-QPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGE 215

  Fly   744 MFAEYCDYCGEAI-GVDQGQ-MSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSK 806
            :||..|..|...| |:..|: :|.:.:|||  ..||||..|..||:|:.|:|....:.|. .||:
Human   216 LFAPKCSSCKRPIVGLGGGKYVSFEDRHWH--HNCFSCARCSTSLVGQGFVPDGDQVLCQ-GCSQ 277

  Fly   807 GEP 809
            ..|
Human   278 AGP 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	16/68 (24%)
		LIM1_Prickle	624..682	CDD:188799	15/57 (26%)
		LIM2_Prickle	687..742	CDD:188802	17/54 (31%)
		LIM3_Prickle	747..805	CDD:188804	20/59 (34%)
FHL3	NP_004459.2	LIM	<5..33	CDD:295319
		LIM1_FHL3	36..94	CDD:188807	13/48 (27%)
		LIM2_FHL3	98..155	CDD:188811	17/79 (22%)
		LIM3_FHL	162..213	CDD:188732	14/51 (27%)
		LIM4_FHL3	221..276	CDD:188818	20/57 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810