DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Zfp185

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_033575.3	Gene:	Zfp185 / 22673	MGIID:	108095	Length:	486	Species:	Mus musculus

Alignment Length:	542	Identity:	104/542 - (19%)
Similarity:	156/542 - (28%)	Gaps:	248/542 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 NLSLRQRSLPRSMK---PFKDAHDISFTFNELDTSAEP------EVATGAAQQESN--EPISRTP 355
            |..|||..:..::|   .:...||     :..|.:.||      ..:..:.:.|||  .|.:|.|
Mouse    23 NNILRQMKVRTTLKGDQSWITKHD-----DSEDHTIEPLSRHNRATSFSSVRDESNARSPNARAP 82

  Fly   356 LTQI------------SYLQKIPT----LPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYA- 403
            ...|            |:.|..|:    .||  |.|||       ||:...|.|..||...:..
Mouse    83 AGYIIRGVFTRTIDSSSHSQHRPSKTNGAPR--SASGQ-------LGAANSGHPLQSSGYKMTTE 138

  Fly   404 ---------------------------------AQAAAGIL----------------PTSPLPLQ 419
                                             :|||.|:|                .|:..|.|
Mouse   139 DYKKLAPYNIRRSSISGTEEEEVPFTPDEQKRRSQAALGVLRKTAPREHSYVLSAAKKTTSSPTQ 203

  Fly   420 RHQ------------QYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPP 472
            ..|            :.:.|...|.|.|...|.||..:              |...|.::.|:.|
Mouse   204 ELQSPFLAKRVDVVDEDVLPEKNQEPPALARPDPGRSS--------------STTEKIAHRQITP 254

  Fly   473 PPHHHHQLSP---ALSTP-------SPPSLLHHPAG----GTSSASAHAPFLG--------GPHM 515
            |....|.::|   |||||       :.|.::....|    |.|..:..:..|.        |...
Mouse   255 PTAELHLVAPDLEALSTPDSCEENNAAPKIIKEIPGTLQDGQSDPTVASQQLADLSILEPQGSPS 319

  Fly   516 DMQRQSHSDD-------DSGCAL--------EEYTWVPPGL--RPDQ---------VRLYF---- 550
            ..::|..::|       .|.|.:        |:.....||:  :.|.         |:.|.
Mouse   320 GAEQQIKAEDCTNMLMSPSSCMVTVTISDTSEQSQLCVPGVSSKVDSSSTIKGILFVKEYMNTSE 384

  Fly   551 --------------SQIPDD-----KVPYVNSPGEQYRVRQLLHQLPPHDNEVRYC-HSLTDEER 595
                          |.|.|.     |.|:..:|.|:           |.:....|| |.:.|..:
Mouse   385 VSSGKPVSSHCDSPSSIEDSLDLAKKAPHEGTPSER-----------PTEGVCTYCSHEIQDCPK 438

  Fly   596 KELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCR 660
            ..|.                                          .||  ...|..||.|.:|.
Mouse   439 ITLE------------------------------------------HLG--ICCHEYCFKCGICN 459

  Fly   661 EL---LVDLIYFHRDGRMYCGR 679
            :.   |:|.|:.||| .::||:
Mouse   460 KPMGDLLDQIFIHRD-TIHCGK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	22/144 (15%)
		LIM1_Prickle	624..682	CDD:188799	15/59 (25%)
		LIM2_Prickle	687..742	CDD:188802
		LIM3_Prickle	747..805	CDD:188804
Zfp185	NP_033575.3	LIM	425..481	CDD:214528	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900