DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Lims2

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001366066.1	Gene:	Lims2 / 225341	MGIID:	2385067	Length:	341	Species:	Mus musculus

Alignment Length:	263	Identity:	70/263 - (26%)
Similarity:	102/263 - (38%)	Gaps:	57/263 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 PDDKVPYVNSPGEQYR-----VRQLLHQLPP---HDNEVR-YC-HSLTDEERKELRLFSTQRKRD 608
            |.:::  |||.||.|.     ..|.....|.   ::.|.| || |..
Mouse    24 PTERI--VNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDF------------------ 68

  Fly   609 ALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDG 673
                    |::.|..|..|      |:..:.......||:|||.||.|.:|...|.||.:....|
Mouse    69 --------QMLFAPCCGFC------GEFVIGRVIKAMNANWHPGCFRCELCDVELADLGFVKNAG 119

  Fly   674 RMYC----GRHHAETL-KPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREG 733
            |..|    .|..|:.| |..|..| .:.:.::....:...:|.:||:|..|.|:|......:: |
Mouse   120 RHLCRPCHNREKAKGLGKFICQRC-HLAIDEQPLMFKNDPYHPDHFSCSNCGKELTSDARELK-G 182

  Fly   734 KPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHD-GQHWHATDECFSCNTCRCSLLGRAFLPRRGA 797
            :.|||.|.|.|....|..|...|   :|::.:. |:.||.  |.|.|..|....||.....::|.
Mouse   183 ELYCLPCHDKMGIPICGACRRPI---EGRVVNALGKQWHV--EHFVCAKCEKPFLGHRHYEKKGL 242

  Fly   798 IYC 800
            .||
Mouse   243 AYC 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	14/73 (19%)
		LIM1_Prickle	624..682	CDD:188799	19/61 (31%)
		LIM2_Prickle	687..742	CDD:188802	14/54 (26%)
		LIM3_Prickle	747..805	CDD:188804	16/55 (29%)
Lims2	NP_001366066.1	LIM1_PINCH	15..73	CDD:188717	15/76 (20%)
		LIM2_PINCH	76..127	CDD:188718	18/56 (32%)
		LIM3_PINCH	140..190	CDD:188719	13/51 (25%)
		LIM4_PINCH	196..249	CDD:188720	16/55 (29%)
		LIM5_PINCH	257..310	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910