DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and Lpp

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001139424.1	Gene:	Lpp / 210126	MGIID:	2441849	Length:	613	Species:	Mus musculus

Alignment Length:	647	Identity:	160/647 - (24%)
Similarity:	231/647 - (35%)	Gaps:	184/647 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 QEAPK---PALPPKQK---QQRP------VPPLPPPPANRVTQDQGTQPAAPQ--VPLQPLTAGD 297
            |:.||   |.:.||.|   .::|      :|| ||||    .:|.||.|..|.  .|..||..|.
Mouse    39 QQPPKKYAPVVAPKPKYNPYKQPGGEGDLLPP-PPPP----LEDPGTIPPGPGHFPPPPPLDEGA 98

  Fly   298 LQF-------LNLSLRQRSLPRSMKPFKDAHDISFT--FNELDTSA--EPEVATGAAQQESNEPI 351
            .:.       ..|..|:.||        ||...|.|  ..:|:.|:  :|....|:|...::.|:
Mouse    99 FKVQQGNPGGKTLEERRSSL--------DAEIDSLTSILADLECSSPYKPRPPQGSASSIASPPV 155

  Fly   352 SRTPLT-----------QISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQ 405
            | ||:|           .::..:|..|.|:   |:.|  |.|..:...|...|......|.|..
Mouse   156 S-TPVTGHKRMVIPQQPPLTATKKSATKPQ---PAPQ--AAPIPVTPIGTLKPQPQPVPASYTT- 213

  Fly   406 AAAGILPTSPLPLQRHQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQL 470
            |:....||..:.::..|.  .||:.        .||.||...||  ||:   |.:..|...:.|.
Mouse   214 ASTSSRPTFNVQVKSAQP--SPHYM--------AGPSSGQIYGP--GPR---GYNNQPVPVSGQC 263

  Fly   471 PPPPHHHHQLSPALSTP---SPPSLLHHPAGGTSSAS----------AHAPFLGGPHMDMQRQSH 522
            ||||       ..:.|.   .||| .|.|..|....|          |..|..||       :|.
Mouse   264 PPPP-------TCVGTDYAYIPPS-GHPPESGYGYTSNQGRYYEPYYAAGPSYGG-------RSE 313

  Fly   523 SDDDSGCALEEYTW------VP--------PGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQL 573
            .|...|..::..||      .|        ||:.|         :...|..|:..|........|
Mouse   314 GDTAYGQQVQPNTWKREAAYAPPASGNQNHPGMYP---------VSGPKKTYITDPVSAPCAPPL 369

  Fly   574 LHQ-----------LPPH---DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPC 624
            ..:           :||.   ::|:.:   ||   :|.|.........|..||           |
Mouse   370 QPKGGYPGPMGPPSIPPSFRPEDELEH---LT---KKMLYDMENPPADDYFGR-----------C 417

  Fly   625 DGCDDLI---STGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLK 686
            ..|.:.:   .||..|:       :..:|..||.|.||...|....::..:.:.||...:..||:
Mouse   418 ARCGENVVGEGTGCTAM-------DQVFHVDCFTCIVCDVKLRGQPFYAVEKKAYCEPCYINTLE 475

  Fly   687 PRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMRE-GKPYCLHCFDAMFAEYCD 750
             :||.|.:.|: :....|.|:|:|.:.|.|..|.:.|.|..:.:.. |..:|:..|...||..|.
Mouse   476 -QCSVCSKPIM-ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDACGLIHCIEDFHKKFAPRCS 538

  Fly   751 YCGEAIGVDQGQ--------MSHDGQHWHATDECFSCNTCRCSLL----GRAFLPRRGAIYC 800
            .|.|.|....||        :..| .|.|    |:.|..|. .||    .:...|..|.|.|
Mouse   539 VCKEPIMPAPGQEETVRIVALDRD-FHVH----CYRCEDCG-GLLSEGDNQGCYPLDGHILC 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	22/122 (18%)
		LIM1_Prickle	624..682	CDD:188799	14/60 (23%)
		LIM2_Prickle	687..742	CDD:188802	15/55 (27%)
		LIM3_Prickle	747..805	CDD:188804	18/66 (27%)
Lpp	NP_001139424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		27/92 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..259		36/147 (24%)
		PRK14971	<139..>240	CDD:237874	26/117 (22%)
		dnaA	192..>388	CDD:237605	52/235 (22%)
		LIM1_TRIP6	417..470	CDD:188736	14/59 (24%)
		LIM	477..536	CDD:351770	18/59 (31%)
		LIM	537..602	CDD:351770	18/64 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810