DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and alp-1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	809	Identity:	152/809 - (18%)
Similarity:	245/809 - (30%)	Gaps:	245/809 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PH------SSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANES-SEVTQRNARVTVLDDPFLFGID 198
            ||      |:||..:.:|.|    |.:.|  |....:....| :::.....::|....|:...:.
Worm   712 PHPDTIDSSTSPIPTIRLNR----HTKPE--PSTPLSVPTVSINDIATSPIKITEPSRPWRASVS 770

  Fly   199 ADHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRP 263
            ......:.:...|...:|.:..:.|.  |::|..:...|...|..||.....|......:....|
Worm   771 NSATSPIKIHESRVQPVDESRGLHRH--EEKAQIETSTIKIHEPSSPPPSVHKFGAVNTRAAPAP 833

  Fly   264 VPPLPPPP-ANRVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDI---- 323
            |..:..|. |.::.:..|..|..|..|..|:......|..:...:.| |..:..:||:.||
Worm   834 VQFMQTPRIAVKIHEPTGPSPTPPSTPSHPIKRDPKHFKKVDFSKTS-PTVIPEWKDSADIVDES 897

  Fly   324 -----------SFTF---------------NELDTSA---------EPEV----------ATGAA 343
                       |.:|               |.:|..:         |.||          ..|..
Worm   898 DILTECSREDDSISFLKAATYDGDESEMIDNNIDNKSDITSTFDIEEEEVDVVQDRERIRVVGRK 962

  Fly   344 QQESNEPISRTPLTQISYLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQAAA 408
            ..|..|       .:..:.|:...|....:.:.:.|....||.....||........:.|.:..|
Worm   963 GGEGGE-------AEKQWRQRAMELLDDDAQTERDLRIVAALNERLQGLREMEDDDRVRAIECIA 1020

  Fly   409 GILPTSPLPLQRHQ---------------------QYLPP------------------------- 427
                       |||                     |.|.|
Worm  1021 -----------RHQSELEQTQTQLSTLLESAIVYLQNLRPELELTEPIDNDAKSLETVKFEPTRA 1074

  Fly   428 ---------------HHQQHPGAGMG--PGPGSGAAAGP-----PLGPQYSPGCSANP------- 463
                           .|....|.||.  |.|.......|     |:.||:....:.:|
Worm  1075 EQRVNEIRKKVLEDLEHLPILGDGMDSVPPPPPERKVFPFQSYQPIAPQFPVPAAESPVTQSLHD 1139

  Fly   464 ---KYSNAQLPPPPHHHHQLSPALSTPSPPSLL----------HHPAGGTSSASAHAPFLGGPHM 515
               ::.:.:.|.|..:..|.|...:..|...|.          :..|||::.:|.|
Worm  1140 VLDEFYSLRKPTPTQNVAQSSDTTAEDSRNFLASRLGQVMIDENKKAGGSNGSSQH--------- 1195

  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580
                  |:...|     .||           :..|.:...:..|..|:..             |.
Worm  1196 ------HNQQGS-----SYT-----------KTSFERTTTETRPQQNTGA-------------PR 1225

  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGP 645
            ..:.|....||          :|...:...||        |..|:.|...|....:      |..
Worm  1226 AGDFRGTGHLT----------TTTTTQQNGGR--------APFCESCKQQIRGAFV------LAT 1266

  Fly   646 NASWHPACFAC--SVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRA 708
            ..||.|..|.|  |.||..|::..:...||:.:|.....:.:.|||:.|.:.|::| |..|..:.
Worm  1267 GKSWCPEHFVCANSSCRRRLLECGFVEEDGQKFCESCFEQHIAPRCNKCSKPIISD-CLNALQKK 1330

  Fly   709 WHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHAT 773
            ||...|.|..|.|..|...:.:.:|.|||...::|:|...|..|...|......:...|..:|:
Worm  1331 WHPTCFTCAHCQKPFGNSAFYLEQGLPYCEQDWNALFTTKCVSCRYPIEAGDRWVEALGNAFHS- 1394

  Fly   774 DECFSCNTCRCSLLGRAFLPRRGAIYCSI 802
             .||:|..|..:|.|.:|..:.|..:|.:
Worm  1395 -NCFTCARCNHNLEGESFFAKNGQPFCRL 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	13/94 (14%)
		LIM1_Prickle	624..682	CDD:188799	16/59 (27%)
		LIM2_Prickle	687..742	CDD:188802	19/54 (35%)
		LIM3_Prickle	747..805	CDD:188804	14/56 (25%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746
		LIM1_Enigma_like_1	1251..1304	CDD:188839	16/58 (28%)
		LIM	1312..1363	CDD:295319	17/51 (33%)
		LIM3_Enigma_like_1	1371..1424	CDD:188845	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920