DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and prkl-1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_741435.2	Gene:	prkl-1 / 177463	WormBaseID:	WBGene00022727	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	176/517 - (34%)
Similarity:	239/517 - (46%)	Gaps:	97/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 PSLL--HHPAGGTSSAS-------AHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQ 545
            |.|:  ....||.|.||       ||            |.|.|||||||||:||.|||.||:|:.
Worm    18 PQLISSRRAQGGLSPASRIRIAADAH------------RHSTSDDDSGCALDEYAWVPSGLKPNM 70

  Fly   546 VRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRDAL 610
            |..||:.:|::|||::.|.||::|.||..:||||.|::||||..|..||...||:|...||.:.|
Worm    71 VHAYFACLPENKVPFIGSAGEKWRQRQSRYQLPPQDSDVRYCEDLNAEEADTLRMFERTRKTECL 135

  Fly   611 GRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRM 675
            |.|.|:.......|:.|...:..|:|:|.|.|.|..  :||:||.|..|..||||||||..|.::
Worm   136 GSGVVQYAPFDTKCEKCPKRLEEGEISVMAARTGKR--YHPSCFRCQTCDVLLVDLIYFAHDNQI 198

  Fly   676 YCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHC 740
            ||||||||.:||||:.|||:|..|||.|||||:||.:||.|.:|:..|..|:|:.|..||.||.|
Worm   199 YCGRHHAEQVKPRCAKCDEVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRANKPVCLKC 263

  Fly   741 FDAMFAEY-CDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIAC 804
            |.:..:.: |..|..:...|...||....||||:.|||.|..|..:|||..:.....:::|....
Worm   264 FHSSSSTFSCTTCRLSFSSDTPHMSQGDLHWHASAECFCCCVCSKNLLGVKYSRVGESLFCGYQT 328

  Fly   805 SKGE------------PPTPSDSSGTGMYTTPTPP----------------------------TQ 829
            ..||            |........|.:...|..|                            .|
Worm   329 CGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQ 393

  Fly   830 RVRPHPQAPLPARIPSSH---------ASSSP----------PMSPQQQQQHQATFNQAMYQMQS 875
            |.:|..:||.|.  ||.:         :::||          |.||.....:..|.|..:.....
Worm   394 RPKPPQRAPPPP--PSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPE 456

  Fly   876 QQMEAAGGLVDQSKSYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPG 937
                     :|...:.::||||.   :.|.....|....|:......:|..|:...|:...|
Worm   457 ---------MDGYSTSSSSDSDD---EQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSG 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	51/94 (54%)
		LIM1_Prickle	624..682	CDD:188799	28/57 (49%)
		LIM2_Prickle	687..742	CDD:188802	30/54 (56%)
		LIM3_Prickle	747..805	CDD:188804	18/58 (31%)
prkl-1	NP_741435.2	PET_Prickle	48..144	CDD:193602	51/95 (54%)
		LIM1_Testin_like	149..204	CDD:188726	27/56 (48%)
		LIM2_Testin_like	210..262	CDD:188727	28/51 (55%)
		LIM	283..324	CDD:295319	15/40 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162454
Domainoid	1	1.000	102	1.000	Domainoid score	I4294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		otm14433
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820