DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and pqn-22

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_500907.2	Gene:	pqn-22 / 177369	WormBaseID:	WBGene00004112	Length:	1165	Species:	Caenorhabditis elegans

Alignment Length:	1261	Identity:	231/1261 - (18%)
Similarity:	354/1261 - (28%)	Gaps:	495/1261 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 VPPLPPP----PANRVTQDQGT-----QPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKD 319
            |||...|    |.:.:...|.|     :.:.|....:| |.|..:..|.....|.:|||..
Worm     9 VPPAIAPLFSLPQSSIDDIQNTSLNSIRSSHPFSYTKP-TPGGPKLHNRIKCPRVVPRSFW---- 68

  Fly   320 AHDISFTFN-ELDTS-AEPEV---------------ATGAAQQESNEPISRTPLTQISYLQKIPT 367
               :||..: |||.. .|||:               :..||.::..:.|..||       ..:|.
Worm    69 ---LSFEEDEELDVPLLEPEMPQTVHLQYNSPMGLYSKEAAVEQFQQQIGETP-------NDLPA 123

  Fly   368 LPRHFSPSGQGLATPPALGSGGMGLPSSSSASALY----------------AAQAAAGILPTSPL 416
            ..:||.|                    |.||:..|                .|||.|..:|....
Worm   124 QEKHFDP--------------------SKSATLKYLKEGERENFGENFFEKVAQAEAPRVPYQSE 168

  Fly   417 P---------LQRHQQYLP--PHHQQHPGAGMGPGPGSGAA------------------AGPPLG 452
            |         .:|.:...|  ||....|.:  .|.|.:...                  ...|.|
Worm   169 PNWARTAREKSERARSKTPADPHTAYRPAS--SPAPANHPVHAENAREHAEKSKVFTHNINEPFG 231

  Fly   453 PQYSPGCSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDM 517
            ..|....:..|:|..:         |.:...|....      :..||..       :.||.|:|
Worm   232 RSYWEASNTVPRYGRS---------HSVGRELYNRG------YELGGMD-------YTGGIHVD- 273

  Fly   518 QRQSHSDD----DSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLP 578
                |..|    :......:...:|||........|...:|.|.....:.|.            |
Worm   274 ----HGTDYQYYEEPARKPQTPKLPPGYELGGTDFYKGHVPGDANYRGHGPD------------P 322

  Fly   579 PHDNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSARPC--------DGCDDLISTGD 635
            |                 .||...|....|              ||        :|.|..:..||
Worm   323 P-----------------RLRPKYTADSHD--------------PCNVAIAPNLEGVDANLLVGD 356

  Fly   636 I---------------AVFATRLGPNASW--------------HPACFACSVCRELLVDLIYFHR 671
            .               ..|.|..||...:              .|..::.|..:.|.       |
Worm   357 TLSNQKIRHEVRHIDQTKFGTSFGPTKGFSYDHHTVPRYVEPPKPVVYSLSANKSLA-------R 414

  Fly   672 DGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLG--------GQRY 728
            ...:           ||.||..|          :...|::..   .|.||::.        ..|.
Worm   415 SASV-----------PRSSAPPE----------QRDVWNIQQ---SEVDKEVNIRTLLTDEALRA 455

  Fly   729 IMREGKPYCL-HC----------FDAMFAEYCDYCGE---AIGVDQGQMSHDGQHWHATDECFSC 779
            ..||..||.. |.          .|.....|..|..|   ...|||.:::.:.:.:.....
Worm   456 PKREQSPYWAGHSEQKHEAWRGRTDPRLQRYETYITEPNWRRNVDQRRLAWERRAFETEQH---- 516

  Fly   780 NTCRCSLLGRAFLPRRGAIYCSIACSKGEPPT--------------PSDSSGTGMYTTPTPPTQR 830
                   |.|.:         |...:.|.||.              .:|:..|..||..|...|.
Worm   517 -------LSRPY---------SEKVAPGVPPAWHAEAQHKHQQWQQQADNMNTQNYTYSTTGYQP 565

  Fly   831 VRPH--PQAPLPARIPSSHASSSPPMSPQ--QQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSY 891
            .:|.  .|:....|..||:|:|:.|...|  ||||||       ||
Worm   566 SQPSGGQQSYNETRQYSSNATSNYPSQTQQYQQQQHQ-------YQ------------------- 604

  Fly   892 AASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVY 956
                ||....:.|.:.|:  ..:..|:..|.....::.           ||:.|.        :.
Worm   605 ----SDHSNAQRLLNSGY--NTNQVDYVLGHKDKYNEG-----------PHYQPP--------II 644

  Fly   957 NFNEMSSNLDAAWSAKPTNSYHLQRQLL-----ENPHTASM----PELAGKLVAPPAHMQHLSQL 1012
            |.:..::|.    |:..|:.|:...|.:     ...|::|.    ..:.|.....|....:.:|.
Worm   645 NSSATAANN----SSSSTHHYNSSSQAIPLGGPNQGHSSSSYTTETRVTGGGTGAPVSNNYSNQN 705

  Fly  1013 HAVSSH--QFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGD------R 1069
            ::.|::  |..||:...|       |.:..::..|.|||::.|.......:...|..:      |
Worm   706 YSSSAYNSQSSQHQTKSI-------PVQNYQISFPPLSVSTPAFGTSFFENSQKSFQESSEKFHR 763

  Fly  1070 SLNTPMS----TQSASH-----------APPHPVSILSGASSSSPMSGEPAKKKGVRFEGIPDTL 1119
            .|.:|:|    .|||.|           ...|.....|...|....:.|.::||...::.....:
Worm   764 DLASPLSRTIPVQSAGHFSEVSKYFNSEETNHESRQESRCHSEVAETTETSEKKEENYQVSQPAI 828

  Fly  1120 P------------RSRSYS--------------GNGAGTSGGGERERDRDKDK---------EGG 1149
            |            .::|||              .|...||...||.......:         :..
Worm   829 PLPSADQVYESSNYNKSYSSQTTTQHQPQPVAANNNYSTSYHTERSSTTTAQQPQTIALPPPQNN 893

  Fly  1150 GRHGHGHSSR----------RRRRRKSSSSSSHHRSGS-------------GHRSHSTTRADTY- 1190
            ..|...|||.          ...:....|||.||:..:             ...::.||:..:|
Worm   894 SSHTETHSSTGPIMMHSPGGHSMKSTEFSSSRHHKQETTTTTTTTPQPPVFQTTTYPTTKTTSYN 958

  Fly  1191 -----APAQPLSSSY---------------QG-PPSVLQAA---NLVHESPSRQQRERERERERE 1231
                 .|:||...|:               || |...||.:   :..:.|.||::..|..|..|.
Worm   959 YSSSTIPSQPAKPSFNQESYTTHTERNNSSQGFPQQRLQPSGGYSYENYSSSRKEENRREETSRP 1023

  Fly  1232 ESEESDVCSTCSSSSSSSEDYMMMYQ 1257
            .|:        .|..|.|.:|...|:
Worm  1024 VSQ--------LSQYSESRNYKRNYE 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	14/98 (14%)
		LIM1_Prickle	624..682	CDD:188799	13/94 (14%)
		LIM2_Prickle	687..742	CDD:188802	15/73 (21%)
		LIM3_Prickle	747..805	CDD:188804	9/60 (15%)
pqn-22	NP_500907.2	DUF4749	88..>146	CDD:374237	13/84 (15%)
pqn-22	NP_500907.2	ZM	88..113	CDD:128974	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100