DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and PRICKLE2

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	XP_011531734.1	Gene:	PRICKLE2 / 166336	HGNCID:	20340	Length:	966	Species:	Homo sapiens

Alignment Length:	937	Identity:	332/937 - (35%)
Similarity:	439/937 - (46%)	Gaps:	234/937 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580
            |.||.|.||||||||||||.||||||:|:||..|:|.:|::||||||||||:.|::|||||||||
Human   111 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPH 175

  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATR 642
            |||||||:||.:||::||:|||:||||:.|||||||..   |:...|:.|...|:.|||||||:|
Human   176 DNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASR 240

  Fly   643 LGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGR 707
            .|....|||.||.|:||.|||||||||::||::||||||||.|||||:||||||.||||||||||
Human   241 AGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGR 305

  Fly   708 AWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHA 772
            .|||.||.|.||:..||||||||:||:|||.|||::::|||||.|.:.||:|||||::|||||||
Human   306 HWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHA 370

  Fly   773 TDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQR------- 830
            |:.||.|..|:.|||||.|||::|.|:||.|||.||.|..||||.:.........::|
Human   371 TETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKN 435

  Fly   831 --------VRPHPQA------------PLPARIPSSHASSSPP-------MSPQQQQQHQATFNQ 868
                    :..|.|.            ||..::.....||..|       ...:::..|...
Human   436 KGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGN--- 497

  Fly   869 AMYQMQSQQMEAAGGLVDQSK---SYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNL 930
               :|:..|.::...|:.|..   ||:.....||...:: .|.|        ||..:.||   :|
Human   498 ---KMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEM-WGKH--------FSNPKRSS---SL 547

  Fly   931 SPLNSPGDF----QPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTAS 991
            :.....|.|    :..:.|..:..|.    ::::|||           .|:...|..::.|....
Human   548 AMTGHAGSFIKECREDYYPGRLRSQE----SYSDMSS-----------QSFSETRGSIQVPKYEE 597

  Fly   992 MPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPP 1056
            ..|..|.|     ..|.....|.:||.::.:    |:......|.|.:..|...|.:.:|.|
Human   598 EEEEEGGL-----STQQCRTRHPISSLKYTE----DMTPTEQTPRGSMESLALSNATGSSLA--- 650

  Fly  1057 ELMGSPTHSAGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMSGEPAKKKGVRFEGIPDTLPR 1121
                       :.|..|...|:..|..    |.||:|.:......|...:::.:....:||....
Human   651 -----------EHSRVTITETEIISRY----VWILTGINVGLSADGGAKRQEHLSRFSMPDLSKD 700

  Fly  1122 SR---SYSGNGAGTSGGGERERDRD-----------KDKEG---------GGR----HGHGHS-- 1157
            |.   |...:..||.....:.|..:           ::.||         |.|    ||..|.
Human   701 SGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSF 765

  Fly  1158 ----------------------SRRRRRRKSSSSSSH----HRSGSGHRSHSTTRADTYAPAQPL 1196
                                  |.|.|||.:|...:.    |||....||.|.......:..:.:
Human   766 DFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAI 830

  Fly  1197 SSSYQGPPSVLQAANLVHESPSRQQRERE------REREREES---------------------- 1233
            |.....||                .|.||      |:|..:||
Human   831 SRLKDRPP----------------LRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLAL 879

  Fly  1234 ------------EESDVCSTCSSSS-SSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYDRKR-- 1283
                        .|.|.|||||||| |.:|.|.:...:||     ..|:.||.:|.|.:....
Human   880 QNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQ-----PARLRYVTSDELLHKYSSYG 939

  Fly  1284 --KPSELGG---------DKDKNCIIS 1299
              |.|.|||         .|.||||||
Human   940 LPKSSTLGGRGQLHSRKRQKSKNCIIS 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	71/94 (76%)
		LIM1_Prickle	624..682	CDD:188799	36/57 (63%)
		LIM2_Prickle	687..742	CDD:188802	42/54 (78%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
PRICKLE2	XP_011531734.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152354
Domainoid	1	1.000	149	1.000	Domainoid score	I4411
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1323
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm8650
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790