DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and Ajuba

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_034720.2	Gene:	Ajuba / 16475	MGIID:	1341886	Length:	547	Species:	Mus musculus

Alignment Length:	712	Identity:	153/712 - (21%)
Similarity:	224/712 - (31%)	Gaps:	248/712 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RSKKLLRSLRAHVRGE-KLPKNDTTTANESSEVT--QRNARVTVLDDPFLFGIDADHLGDLVVRG 209
            ::.:||..||....|. |..:.....:...|:.|  ....|::.|..|...|    |.|  ...|
Mouse     7 KASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAGKGRLSGLGGPRKSG----HRG--ANGG 65

  Fly   210 KRYSTLDATENMARFYAEQEATAQVLEIIEQEEESPEQEAPKPALPPKQKQQRPVP-PLPPPPAN 273
            .....|:.........||:.|....        |:...|...|..||   ..|.:| ||..||..
Mouse    66 PGDEPLEPAREQGPLDAERNARGSF--------EAQRFEGSFPGGPP---PTRALPLPLSSPPDF 119

  Fly   274 RVTQDQGTQPAAPQVPLQPLTAGDLQFLNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEV 338
            |:   :.|.||                  ||      |||          ||..:....:::|..
Mouse   120 RL---ETTAPA------------------LS------PRS----------SFASSSASDASKPSS 147

  Fly   339 --------ATGAAQQESNEPIS-RTPLTQISYLQKIPTLPRHFSPSGQG-------LATPPALGS 387
                    ..||:....:.|.| ||....:.|.|      ||.||...|       |.|.||...
Mouse   148 PRGSLLLDGAGASGAGGSRPCSNRTSGISMGYDQ------RHGSPLPAGPCLFGLPLTTAPAGYP 206

  Fly   388 GGMGLPSSSSASALYAAQAAAGILPTSPLPLQR---HQQY----LPPHHQQHPGAGMGPGPGSGA 445
            ||    :.|:...|:||             |.|   |:..    ....|...|..| .||..:||
Mouse   207 GG----APSAYPELHAA-------------LDRLCAHRSVGFGCQESRHSYPPALG-SPGALTGA 253

  Fly   446 AAGP--PL---GPQYSPG---------CSANPKYSNAQLPPPPHHHHQLSPALSTPSPPSLLHHP 496
            ..|.  ||   |.|  ||         |:|..:|.:           :|:..|.       |...
Mouse   254 VVGTAGPLERRGAQ--PGRHSVTGYGDCAAGARYQD-----------ELTALLR-------LTVA 298

  Fly   497 AGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYV 561
            .||.                         ::|...|     |.|:.|       |.:.:...|:|
Mouse   299 TGGR-------------------------EAGARGE-----PSGIEP-------SGLEESPGPFV 326

  Fly   562 NSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRK--RDALGRGNVRQLMSARPC 624
             ....:.|:|:                   .|.|::  .|.|..|  :...|:.|.        |
Mouse   327 -PEASRSRIRE-------------------PEARED--YFGTCIKCNKGIYGQSNA--------C 361

  Fly   625 DGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHA----ETL 685
            ...|.|                  :|..||.|..|...|....::..:|.:||...:.    :..
Mouse   362 QALDSL------------------YHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEA 408

  Fly   686 KPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMR-EGKPYCLHCFDAMFAEYC 749
            ..:|..|..:|| ::..:|.|:::|...|.|..|:|.|.|..:.:. ..:.||:..:...:|..|
Mouse   409 AEKCCVCGHLIL-EKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAPKC 472

  Fly   750 DYCGEAIGVDQG--------QMSHDGQHWHATDECFSCNTCRCSLL---GRAFLPRRGAIYC 800
            ..||:.|...:|        .|..|   :|.  ||:.|..||..|.   |....|..|.:.|
Mouse   473 AACGQPILPSEGCEDIVRVISMDRD---YHF--ECYHCEDCRMQLSDEEGCCCFPLDGHLLC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	17/96 (18%)
		LIM1_Prickle	624..682	CDD:188799	12/57 (21%)
		LIM2_Prickle	687..742	CDD:188802	15/55 (27%)
		LIM3_Prickle	747..805	CDD:188804	18/65 (28%)
Ajuba	NP_034720.2	PreLIM	1..344		102/493 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		50/234 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	289..297		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..332		8/67 (12%)
		LIM1_Ajuba_like	347..400	CDD:188738	15/78 (19%)
		LIM2_Ajuba_like	412..464	CDD:188741	15/52 (29%)
		LIM3_Ajuba_like	472..533	CDD:188822	18/63 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900