DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pk and PRICKLE1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001138353.1	Gene:	PRICKLE1 / 144165	HGNCID:	17019	Length:	831	Species:	Homo sapiens

Alignment Length:	891	Identity:	323/891 - (36%)
Similarity:	437/891 - (49%)	Gaps:	185/891 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 QRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDN 582
            ||.|.||||||||||||.||||||||:|::|||:.:|::||||||||||::|::|||:|||||||
Human    17 QRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDN 81

  Fly   583 EVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSA---RPCDGCDDLISTGDIAVFATRLG 644
            |||||.||::||:|||::||.|||::|||||.::.|..|   ..|:.|...|:.|::||||:|.|
Human    82 EVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAG 146

  Fly   645 PNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAW 709
            |...|||:||.|..|.|||||||||::||:::|||||||.||||||||||||.||||||||||.|
Human   147 PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHW 211

  Fly   710 HMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATD 774
            ||.||.|.||:..||||||||::|:|:|..||::::||||:.|||.||||..||::||||||||:
Human   212 HMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE 276

  Fly   775 ECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPL 839
            .||||..|:.||||..|||::|.||||..||.||....||||.:...:..:..::|
Human   277 ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRR--------- 332

  Fly   840 PARIPSSHASS---------SPPMS---PQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYA 892
            ..|:..|..|:         ||.::   |........|.::.:..:         .|..|..|:|
Human   333 SVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDL---------SLSRQGTSFA 388

  Fly   893 ASDSDAGVVKD---------LEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPM 948
            :.:...|.|:.         .:|..:|                :|.|........|||.  |..|
Human   389 SEEFWKGRVEQETPEDPEEWADHEDYM----------------TQLLLKFGDKSLFQPQ--PNEM 435

  Fly   949 ELQR-------DGVYNFNEMSSNLDAAWSAK-PTNSYHLQRQ-LLENPHTASMPELAGKLVAPPA 1004
            :::.       :.|.:..|:..|..:..|.| .::.|..|.| .|.:....|.|        .||
Human   436 DIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHP--------GPA 492

  Fly  1005 HMQHLSQL---HAVSSHQFQQHE-YADILH------PPPPPPGEIPELPTPNLSVAS----TALP 1055
            ..:.|.:|   |..|.:...:.: |.|.|.      |.......:..|...|::.||    ....
Human   493 SSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGENKPR 557

  Fly  1056 PEL-------------------MGSPTHSAGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMS 1101
            |.|                   ||         :||:.|..:||.       |:.|.:|...|..
Human   558 PSLYSLQNFEEMETEDCEKMSNMG---------TLNSSMLHRSAE-------SLKSLSSELCPEK 606

  Fly  1102 GEPAKKKGVRFEGIPDTLP---RSRSYS-------GNGAGTSGG----------GERERDRDKDK 1146
            ..|.:|        |..||   ||:|.|       .:....:|.          .||.|.|..:.
Human   607 ILPEEK--------PVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTRRRVYNF 663

  Fly  1147 EGGGRHGHGHSSRRRRRRKSSSSSSHHRSGSGHRSHS-TTRADTYAP-----------AQPLSSS 1199
            |..|...|.|  ||||.|||.|.::.:.  ...|.:| ..|...|.|           |:.:.:.
Human   664 EERGSRSHHH--RRRRSRKSRSDNALNL--VTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAY 724

  Fly  1200 YQGPPSVLQAANLVHESPSRQQREREREREREESEESDVCSTCSSSSSSSED-YMMMYQLPQRRH 1263
            .|......|.|:...:. ..|.....|.......::...||:.||||.|.|: |.:...:||.|.
Human   725 IQNADLYGQYAHATSDY-GLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLGQPIPQPRP 788

  Fly  1264 YGGVRVSYVPND------ALAY----DRKRKPSELGGDKDKNCIIS 1299
            .   |.:|..:|      ||..    .|..|..:..|.|.||||||
Human   789 Q---RFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	68/94 (72%)
		LIM1_Prickle	624..682	CDD:188799	33/57 (58%)
		LIM2_Prickle	687..742	CDD:188802	40/54 (74%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
PRICKLE1	NP_001138353.1	PET_Prickle	22..118	CDD:193602	68/95 (72%)
		LIM1_Prickle_1	126..184	CDD:188867	33/57 (58%)
		LIM2_Prickle	189..244	CDD:188802	40/54 (74%)
		LIM3_Prickle	249..307	CDD:188804	37/57 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..342		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688		12/26 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831		25/70 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4411
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1323
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm8650
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900