DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pk and Prickle1

DIOPT Version :9

Sequence 1:	NP_724538.1	Gene:	pk / 45343	FlyBaseID:	FBgn0003090	Length:	1299	Species:	Drosophila melanogaster
Sequence 2:	NP_001028389.1	Gene:	Prickle1 / 106042	MGIID:	1916034	Length:	832	Species:	Mus musculus

Alignment Length:	879	Identity:	328/879 - (37%)
Similarity:	434/879 - (49%)	Gaps:	160/879 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 QRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDN 582
            ||.|.||||||||||||.||||||||:|::|||:.:|::||||||||||::|::|||:|||||||
Mouse    17 QRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDN 81

  Fly   583 EVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQLMSA---RPCDGCDDLISTGDIAVFATRLG 644
            |||||.||::||:|||::||.|||::|||||.::.|..|   ..|:.|...::.|::||||:|.|
Mouse    82 EVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAG 146

  Fly   645 PNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAW 709
            |...|||:||.|..|.|||||||||::||:::|||||||.||||||||||||.||||||||||.|
Mouse   147 PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHW 211

  Fly   710 HMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATD 774
            ||.||.|.||:..||||||||::|:|:|..||::::||||:.|||.||||..||::||||||||:
Mouse   212 HMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE 276

  Fly   775 ECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPL 839
            .||||..|:.||||..|||::|.||||..||.||....||||.:...:..:..::|
Mouse   277 ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRR--------- 332

  Fly   840 PARIPSSHASS---------SPPMS---PQQQQQHQATFNQAMYQMQSQQMEAAG--------GL 884
            ..|:..|..|:         ||.::   |........|.::.:..:.....:.||        ..
Mouse   333 SVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKAR 397

  Fly   885 VDQSKSYAASDSDAGVVKDLEHGGHMGG-----GDLTDFSGGRASSTSQNLSPLNSPGDFQPHFL 944
            |:|.   |:.|.:...    ||..:|..     ||...|     ...|..:.|..|     .|::
Mouse   398 VEQE---ASEDPEEWA----EHEDYMTQLLLKFGDKNLF-----QQQSSEVDPRAS-----EHWI 445

  Fly   945 PKPMELQRDGVYNFNEMSSNLDAAWSAK-PTNSYHLQRQ-LLENPHTASMPELAGKLVAPPAHMQ 1007
            |..|      |.|..|:..|.....|.| .::.|..|.| .|.:....|.|        .||..:
Mouse   446 PDNM------VTNKPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHP--------GPASSR 496

  Fly  1008 HLSQL---HAVSSHQFQQHE-YADILH------PPPPPPGEIPELPTPNLSVAST---ALP-PEL 1058
            .|.:|   |..:.:...|.: |.|.|.      |.......:..|...|::.||.   :.| |.|
Mouse   497 RLQELDLDHGAAGYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPSL 561

  Fly  1059 MGSPTH---SAGDRSLNTPMSTQSASHAPPHPVSILSGASSSSPMSGEPAKKKGVRFEGIPDTLP 1120
            ......   .|.|....:.|.|.::|.......|:.|..|...|....|.:|        |..||
Mouse   562 YSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEK--------PAHLP 618

  Fly  1121 ---RSRSYS------------GNGA-----GTSGGGERERDRDKDKEGGGRHGHGHSSRRRRRRK 1165
               ||:|.|            .||:     ......||.|.|....|..|...|.|  |.||.||
Mouse   619 VLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHH--RHRRSRK 681

  Fly  1166 SSSSSSHHRSGSGHRSHST-TRADTYAP-----------AQPLSSSYQGPPSVLQAANL----VH 1214
            |.|.::.:.  ...|.:|. .|...|.|           |:.|.       :.:|.|||    .|
Mouse   682 SRSDNALNL--VTERKYSAKDRLRLYTPDNYEKFIQNKSARELQ-------AYMQNANLYSQYAH 737

  Fly  1215 ESPSRQQREREREREREESEESDVCSTCSSSSSSS----EDYMMMYQLPQRRHYGGVRVSYVPND 1275
            .:.....:.....|......|.| .|.||||:|||    |.|.:...:||.|..   |.:|..:|
Mouse   738 ATSDYALQNPGMNRFLGLCGEDD-DSWCSSSTSSSDSEEEGYFLGQPIPQPRPQ---RFTYYTDD 798

  Fly  1276 ALA----------YDRKRKPSELGGDKDKNCIIS 1299
            ..:          ..|..|..:..|.|.||||||
Mouse   799 LSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	68/94 (72%)
		LIM1_Prickle	624..682	CDD:188799	32/57 (56%)
		LIM2_Prickle	687..742	CDD:188802	40/54 (74%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)
Prickle1	NP_001028389.1	PET_Prickle	22..118	CDD:193602	68/95 (72%)
		LIM1_Prickle_1	126..184	CDD:188867	32/57 (56%)
		LIM2_Prickle	189..244	CDD:188802	40/54 (74%)
		LIM3_Prickle	249..307	CDD:188804	37/57 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..342		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688		11/26 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..832		22/69 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4410
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1317
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	1	1.000	-	-		mtm8883
orthoMCL	1	0.900	-	-		OOG6_105250
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3342
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860