Protein Alignment pk and prickle3

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: XP_031747016.1
• Gene: prickle3 / 100490600
• XenbaseID: XB-GENE-940034
• Length: 571
• Species: Xenopus tropicalis
• Alignment Length: 608
• Identity: 208/608 - (34%)
• Similarity: 278/608 - (45%)
• Gaps: 171/608 - (28%)

  Fly   518 QRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDN 582
            ||.|..|..|..:||:|.|.|.||.|.||..:|...|:.|:||::||||:||::||||||||||:
 Frog    74 QRDSLCDSGSDSSLEKYAWAPSGLNPMQVHQFFKCFPEKKIPYISSPGERYRLKQLLHQLPPHDS 138

  Fly   583 E-----------------------VRYCHSLTDEERKELR-LFSTQRKRDALGRGNVRQL---MS 620
            |                       .|||.||..||.:||. |||.:|:.:.||||.||.:   ||
 Frog   139 ETWCCCLFCARPSTAVSCKLVLSQARYCCSLQGEEEEELLVLFSQKRRLENLGRGCVRPVSGTMS 203

  Fly   621 ARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETL 685
            ...|..|...||.||:||||:|.|....|||.||.|:.|.|||.|||||::||::||||||||..
 Frog   204 GTVCQQCGHQISVGDVAVFASRAGLGFCWHPQCFTCAQCLELLCDLIYFYQDGKVYCGRHHAELK 268

  Fly   686 KPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCD 750
            :|||.||||:|.:.|||:|||..||..||.|.||:..|||.||||::.:|:|..|:|.::|:|||
 Frog   269 RPRCLACDEVIFSLECTQAEGFHWHTRHFCCFECECPLGGHRYIMKDQRPFCCSCYDRLYAQYCD 333

  Fly   751 YCGEAI------GVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEP 809
            .|||.|      |:|:||:::.||||||::.||.|..|...||||.||||:|.||||.:||.
 Frog   334 SCGECIDGLFLLGIDEGQLTYGGQHWHASESCFCCGRCGVCLLGRPFLPRQGQIYCSRSCSI--- 395

  Fly   810 PTPSDSSGTGMYTTPTPPTQRVRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQ 874
                      ::|.|                                      :.:|:....::.
 Frog   396 ----------LHTKP--------------------------------------ERSFSPLQTELS 412

  Fly   875 SQQMEAAGGLVDQSKSYAAS---DSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSP 936
            .|:         ::|....|   |.:...:.|...||......:.|     ...||:. :|:.|
 Frog   413 LQK---------ETKDVGTSTNHDIEGDSINDCTLGGSRRSLSVID-----QVPTSRG-APIRS- 461

  Fly   937 GDFQPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPELAGKLVA 1001
              ........|.|..|                                |:|:..|:|:|:.....
 Frog   462 --LHSSLRGAPREFSR--------------------------------ESPNRRSLPDLSSHTRT 492

  Fly  1002 P-------PAHMQ-----HLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTAL 1054
            |       |...:     .||:....||......|....|..|.|.|        |.|.
 Frog   493 PTRVTFQIPLSSEIKESVSLSRPSFTSSSSSSDEEEGYFLGEPIPLP--------PFLR------ 543

  Fly  1055 PPELMGSPTHSAGDRSLNTPMST 1077
            ||....||:|:        |.||
 Frog   544 PPGYTASPSHA--------PTST 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	53/118 (45%)
		LIM1_Prickle	624..682	CDD:188799	34/57 (60%)
		LIM2_Prickle	687..742	CDD:188802	31/54 (57%)
		LIM3_Prickle	747..805	CDD:188804	34/63 (54%)
prickle3	XP_031747016.1	PET	79..199	CDD:471291	53/119 (45%)
		LIM1_Prickle	207..265	CDD:188799	34/57 (60%)
		LIM2_Prickle	270..325	CDD:188802	31/54 (57%)
		LIM	330..394	CDD:413332	34/63 (54%)