Protein Alignment MTM1 and mtm

DIOPT Version :10

• Sequence 1: XP_047298088.1
• Gene: MTM1 / 4534
• HGNCID: 7448
• Length: 625
• Species: Homo sapiens
• Sequence 2: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 333/629 - (52%)
• Similarity: 434/629 - (68%)
• Gaps: 38/629 - (6%)

Human     7 RMASASTSKYNSHSLENESIKRTS--------RDGVNRDLTEAVPRLPGETLITDK-EVIYICPF 62
            ::||.:.|   |:||::.| |.:|        .:|:.||.....  |.||.....| :|.|:||:
  Fly    10 KLASKTAS---SNSLDSSS-KSSSLGSKHGGGENGILRDTPFGY--LEGEEDQDQKNDVTYVCPY 68

Human    63 NGPIKGRVYITNYRLYLRSLETLSSHWRFEVDTCLFQDSSLILDVPLGVISRIEKMGGATSRGEN 127
            .||:.|.:.|||||||.|||....            |:..:::|||||||:|:||:|||||||||
  Fly    69 RGPVFGALTITNYRLYFRSLPLRD------------QEPPVVVDVPLGVIARVEKIGGATSRGEN 121

Human   128 SYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNV------DGW 186
            |||::|.||||||||||.||:.||||.:||.|...||||::|..||||.:....:|      |||
  Fly   122 SYGIEIFCKDMRNLRFAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAFAHAAANSVNGNGGWDGW 186

Human   187 TVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLS 251
            .||.|:.|.||.|:||..||.|.:|:.|.:||:|||:..||..||||.|||||.||||.|:||||
  Fly   187 AVYEPLAELRRLGVPNDMWRATKLNESYAICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLS 251

Human   252 WIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGG 316
            |::|..:..|.||||||||:|||||.|||.||..|.|.|.|..||||.|||||.||:||||.|||
  Fly   252 WMNPRTQATITRCSQPLVGVSGKRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGG 316

Human   317 YESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQ 381
            |||:|||.|.|:.||||||||||||||:|||:..:|..::|.|.:::::|.||:||:.:|.||::
  Fly   317 YESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVR 381

Human   382 VADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGH 446
            :.|||.:..:||:||||||||||||||:|:||:||..||::.|||:|::|||:||||||..||||
  Fly   382 IVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGH 446

Human   447 GDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQ 511
            ||..|:||||||:||||||.|||:|:||..||||||.|||.|:||||||||||||.|.|:.|..:
  Fly   447 GDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAE 511

Human   512 KVTERTVSLWSLINSNKEKFKNPF---YTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPN 573
            .:..:|.|||:.|||:.:::.||.   :|.....||.|:||:|.:.||...|.||||.:...|..
  Fly   512 DLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWNPGLCAPQHG 576

Human   574 PVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQM 617
            .  ||..|||:.:|:..|.:.||:|.::.:.:...|:....|.|
  Fly   577 C--QRTRELLSKQDQLFKLVNELRLKSNNRSNSMQTTTRLASPM 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTM1	XP_047298088.1	PH-like	51..165	CDD:473070	62/114 (54%)
		Myotub-related	184..511	CDD:461958	210/326 (64%)
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	62/113 (55%)
		Myotub-related	184..509	CDD:461958	209/324 (65%)