Protein Alignment MTM1 and ymr1

DIOPT Version :10

• Sequence 1: XP_047298088.1
• Gene: MTM1 / 4534
• HGNCID: 7448
• Length: 625
• Species: Homo sapiens
• Sequence 2: NP_593789.1
• Gene: ymr1 / 2542522
• PomBaseID: SPAC19A8.03
• Length: 559
• Species: Schizosaccharomyces pombe
• Alignment Length: 574
• Identity: 197/574 - (34%)
• Similarity: 288/574 - (50%)
• Gaps: 102/574 - (17%)

Human    66 IKGRVYITNYRLYLRSLETLSSHWRFEVDTCLFQDSSLILDVPLGVISRIEKMGGATSRGENSYG 130
            :.|.:::|.|    .|:.::|.:.: |:.|..    |:|.:|.|             ...|.|:.
pombe    21 LNGTLHLTAY----HSIFSISENGK-EIWTAY----SMINNVKL-------------CSNEKSFC 63

Human   131 LDITCKDMRNL--RFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFL-----NEEKFNVDGWTV 188
            :.|.|:|....  ||   |......|:::.|.......:.:: |:||.     :|||. ...|..
pombe    64 IRIQCRDFMFFCWRF---QSTEDAMDVYDTLQELMSINSINM-LYAFYYMPSGDEEKL-PSSWKS 123

Human   189 YNPVEEYRRQGLPNH--------HWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRN 245
            :....||||.|:.:.        :||||.||:.|..|.:||..|.||...||..:.....:||:|
pombe   124 FLLENEYRRMGVGDSTQADGAGGNWRITKINENYSECHSYPQALAVPASISDSVIYYGCKYRSKN 188

Human   246 RIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLT-IYDARPSVNAVA 309
            |.|.|:::| :|...|.|.||||||:...|:..|||.::.|..|:....|.. |.|||||.||:|
pombe   189 RFPTLTYLH-KNSFSITRASQPLVGIRQNRSAQDEKLVEAIFATSIIPGKENLIVDARPSTNAMA 252

Human   310 NKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEES---HWLSSLESTHWLEH 371
            |.|.|.|.|:.|.|..|:..:|.|.||||||:||.|:.:.: .|.:.|   ..:..|..:.||:|
pombe   253 NIAVGAGSENMDHYRFAKKIYLGIDNIHVMRDSLNKIVNAL-KNTDISAAPPLIELLNRSSWLKH 316

Human   372 IKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISF 436
            :..:|.||:.:...|....:.||||||||||||:||.:|..|.||.:||:||||..||:|:|:||
pombe   317 LANILQGAVLIVKTVHFRHAHVLVHCSDGWDRTSQLCALPQLCLDPYYRTIEGFFALVEKDWLSF 381

Human   437 GHKFASRIGH--GDK-------------------------------------NHTDADRSPIFLQ 462
            ||:||.|..|  |.:                                     :|::...||:|.|
pombe   382 GHRFAERCCHLPGKRIFTIDSSYSEEPPQSSPSSTLQYTFSTVRSALSGFSIDHSEKMMSPVFHQ 446

Human   463 FIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSN 527
            |:|||||:..|||..|||||:||..:|.|||||::|:||:|.|..|.:..|:..|..:|....|.
pombe   447 FLDCVWQIMDQFPNCFEFNERFLRRLLYHLYSCQYGSFLYNSERERAQASVSTHTRCIWDYFLSR 511

Human   528 KEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQ-----PNPVE 576
            |::||||.|....:.::...:|:|    |      |:....|..     |:|.|
pombe   512 KDEFKNPNYVPYDDVIMPDPSSLR----W------WSASFAQPDENMNIPSPSE 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTM1	XP_047298088.1	PH-like	51..165	CDD:473070	21/100 (21%)
		Myotub-related	184..511	CDD:461958	152/377 (40%)
ymr1	NP_593789.1	PH-like	4..94	CDD:473070	21/97 (22%)
		Myotub-related	120..492	CDD:461958	151/373 (40%)