Protein Alignment MTM1 and mtm-1

DIOPT Version :10

• Sequence 1: XP_047298088.1
• Gene: MTM1 / 4534
• HGNCID: 7448
• Length: 625
• Species: Homo sapiens
• Sequence 2: NP_491531.2
• Gene: mtm-1 / 172148
• WormBaseID: WBGene00003475
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 260/609 - (42%)
• Similarity: 372/609 - (61%)
• Gaps: 50/609 - (8%)

Human    10 SASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLI-TDKEVIYICPFNGPIKGRVYIT 73
            |....::.|.|:..|||          ||    ..|..|:|| |:|.|.|..|. |...|::.||
 Worm     8 SGEVGEFASSSMIQESI----------DL----KLLAAESLIWTEKNVTYFGPL-GKFPGKIVIT 57

Human    74 NYRLYLRSLE--TLSSHWRFEVDTCLFQDSSLILDVPLGVISRIEKMGGATS----RGENSYGLD 132
            .||:.....:  .:...|:              ||:|||.:|||||:|..|:    ||:::||..
 Worm    58 RYRMVFLVGDGGKMYEQWK--------------LDIPLGQVSRIEKVGRKTTSVAKRGDDNYGFT 108

Human   133 ITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLN---EEKFNVDGWTVYNPVEE 194
            |.|||.|..||........|:::.:.|.||||||:|:||:||.::   ..:...|||.:|:..:|
 Worm   109 IYCKDYRVYRFTCNPASSDRKNVCDSLNRYAFPLSHNLPMFASVHAAETPRLMKDGWKIYSAEKE 173

Human   195 YRRQGLPNHH-WRITFINKCYELCDTYPALLVVP---YRASDDDLRRVATFRSRNRIPVLSWIHP 255
            |.|.|:||.. |:...|||.|:..:|||...|:|   :......::::..|||:.||||||||:.
 Worm   174 YERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGKPFVKKLGEFRSKERIPVLSWINQ 238

Human   256 ENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESD 320
            .....|.|||||:.|:||||:.:||::|..|...|....:|.|.||||:|||..|||.|||||.:
 Worm   239 TTLASISRCSQPMTGISGKRSAEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYEEN 303

Human   321 DAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADK 385
              |.||.|.||:||||||:|:|||::...:.|.|:|..:..:|:.:.||.|::.:|.||::....
 Worm   304 --YVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFN 366

Human   386 VSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKN 450
            |.:.|.|||:|||||||||||||||||:.|||:||:||||.:|::|||.||||||..||||||.|
 Worm   367 VDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDN 431

Human   451 HTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESAR-ERQKVT 514
            ::|.:|||:|:||.||:||:.:|||.||||.::.||.:||.||:||:||||:|.|..| :.:|..
 Worm   432 YSDGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDKKCD 496

Human   515 ERTVSLWSLINSNKEKFKNPFYTK-EINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQR 578
            |.|:|.||.:..||:||:||.:.. :.|:|:....|:..|.:|::||.|.||.:.......|:|.
 Worm   497 ETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCGLHVWIDYYARSNPYVVTPNHEDVQQP 561

Human   579 YMELLALRDEYIKRLEELQLANSA 602
            ..:.:   ||..:.|:|:...:.|
 Worm   562 GAQFV---DEKKQLLDEIMALDDA 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTM1	XP_047298088.1	PH-like	51..165	CDD:473070	41/120 (34%)
		Myotub-related	184..511	CDD:461958	171/331 (52%)
mtm-1	NP_491531.2	PH-GRAM_MTM-like	36..141	CDD:275407	40/119 (34%)
		Myotub-related	163..489	CDD:461958	170/327 (52%)