DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment net and TAL1

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	331	Identity:	70/331 - (21%)
Similarity:	114/331 - (34%)	Gaps:	124/331 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KDSPNSNDRDA--------------GFCSASSESEGGDDLVVEHARSGSPDIRP----------K 64
            :..|....|||              |....:|.:...:..|:|....|.|...|          |
Human    11 RSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGPGGGPAGGGGAARDLK 75

  Fly    65 GTDSADSKPIALVRNKRKSSEPFKVVGLTTPNSKSMPGP---PSSASMNATGPLKKRIRYTSSAD 126
            |.|:|.::    .|::..::|      |..|     |||   |:.||:.|..|...|:
Human    76 GRDAATAE----ARHRVPTTE------LCRP-----PGPAPAPAPASVTAELPGDGRM------- 118

  Fly   127 SAVVLTPPAIDSPPPNSCIPSTLRLQHEIMPNPAHIYVRHPGVTTLHRSLAAHPEQLEPLALVTT 191
              |.|:|||:.:|               ..|..|.:|.....:.:|.......|   :...:.||
Human   119 --VQLSPPALAAP---------------AAPGRALLYSLSQPLASLGSGFFGEP---DAFPMFTT 163

  Fly   192 KKQCVDQAGPKIEAFSALLIGKQPSAKKTLKERTQKESTSSSFLEASLSDEDLNKTGLAPISRPH 256
            ..:                :.::||.                 .|..::|            .||
Human   164 NNR----------------VKRRPSP-----------------YEMEITD------------GPH 183

  Fly   257 QHQRNYKNMTR-ERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLSKLSVLRVACSYILTL 320
                     |: .|||..|:|||.|...::.|:..||:.:|.:...:||||..:||:|..||..|
Human   184 ---------TKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFL 239

  Fly   321 SRMAGE 326
            :::..:
Human   240 AKLLND 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	21/50 (42%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86		10/49 (20%)
		HLH	193..243	CDD:197674	19/49 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910