DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment net and atoh8

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001073460.2	Gene:	atoh8 / 561606	ZFINID:	ZDB-GENE-061215-7	Length:	266	Species:	Danio rerio

Alignment Length:	298	Identity:	89/298 - (29%)
Similarity:	140/298 - (46%)	Gaps:	50/298 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TDSADSKPIALVRNKRKSSEPFKVVGLT-TPNSKSMPGPPSSASMNATGPLKK--RIRYTSSADS 127
            |.|.|.|      .|||:.||.|.|... .|..|....|...|.....|..::  |....:|.|.
Zfish    15 TVSGDKK------MKRKAREPIKHVSEDHYPYFKLYKNPHLMAETLGDGSPQETHRSEIITSRDD 73

  Fly   128 AVVLTPPAIDSPPPNSCIPSTLRLQHEIMPNPAHIYVRHPGVTTLHRSLAAHPE-QLEPLALVTT 191
            :|           .|..:.:.:.::                :.|:  :.|..|: :|..::..|.
Zfish    74 SV-----------RNDVLNTAVDMR----------------INTI--TAAEVPDSKLRSVSEKTV 109

  Fly   192 KKQCVDQAGPKIEAFSALLIGKQPSAKKTLKERTQKESTSSSFLEASLSDEDLNKTGLAPISRPH 256
            ..:.| ||.|::...||..:  .|..:..|.:|...::.:..   :..::....:.|     .|.
Zfish   110 NSKIV-QASPQVSVLSAPQV--FPLERVVLSQRAASQAPAGG---SERAESPRKRAG-----EPS 163

  Fly   257 QHQRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLSKLSVLRVACSYILTLS 321
            ......|.:.:.||:.|||||||||||||||:|.||:.||.|:..||||||::||:||:|||:|:
Zfish   164 GVVTEIKAIQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLA 228

  Fly   322 RMAGEDYSADQSVPSIATCLEAVTSTIQTEGKVKRKKD 359
            ::|..||:.|....|...|:|..|.|:|.||:.|::|:
Zfish   229 QLADLDYTPDHRNMSFRECVEQCTRTLQAEGRSKKRKE 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	36/50 (72%)
atoh8	NP_001073460.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164		2/31 (6%)
		Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	175..188		9/12 (75%)
		HLH	176..227	CDD:278439	36/50 (72%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	189..227		25/37 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580853
Domainoid	1	1.000	78	1.000	Domainoid score	I8729
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007208
OrthoInspector	1	1.000	-	-		oto41071
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5566
SonicParanoid	1	1.000	-	-		X5318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830