DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment net and Tcf12

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_037308.1	Gene:	Tcf12 / 25720	RGDID:	3829	Length:	707	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	92/439 - (20%)
Similarity:	146/439 - (33%)	Gaps:	154/439 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SASELSAIIMKDSPNSNDRDA-----GFCSASSESEGGDDLVVEHARSGSPDIRPKGTDSADSKP 73
            |.|....:....:|..|..|:     |  :|:..|:.||.|....|...|||.......|..|.|
  Rat   301 STSSSPYVAASHTPPINGSDSILGTRG--NAAGSSQTGDALGKALASIYSPDHTSSSFPSNPSTP 363

  Fly    74 IALVRNKRKSSEPFKVVGLTTPNSKSMP-----GPPSSASMNATGPLKKRI-------------- 119
            :.       |..|.      |..:...|     .|.|.:..|:...||.|:
  Rat   364 VG-------SPSPL------TAGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSF 415

  Fly   120 ------------RYTSSADSAVVLTPPAIDSPPPNSCIPSTLRLQHEIMPNPAH----------- 161
                        |.....|:..||...|:.   |::.:|::....|.:: .|:|
  Rat   416 LKDVCEQSRMEDRLDRLDDAIHVLRNHAVG---PSTSLPTSHSDIHSLL-GPSHNAPIGNLNSNY 476

  Fly   162 ------IYVRHPGVTTLHR---------------SLAAHPEQLE-------------------PL 186
                  ...|...:...||               ::||...:|.                   |.
  Rat   477 GGSSLVTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPESFRGGVQNQSGSVVPT 541

  Fly   187 ALVTTKKQCVDQAGPKIEAFSALLIGKQPSA--KKTLKERTQKESTSSSFLEASLS--DEDLNKT 247
            .:.|..|:..:.            :.:.||:  .|:..|.:||:...||....|.:  |||||
  Rat   542 EIKTENKEKDEN------------LHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLN-- 592

  Fly   248 GLAPISRPHQHQRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQK-LSKLSVLR 311
                   |.|.....|    |||:..|||||.||..|:.|::.|.:....:..::| .:||.:|.
  Rat   593 -------PEQKIEREK----ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILH 646

  Fly   312 VACSYILTLSRMAGEDYSADQSVPSIATCLEAVTSTIQTEGKVKRKKDE 360
            .|.:.||:|.:...|     :::...|.||             ||:::|
  Rat   647 QAVAVILSLEQQVRE-----RNLNPKAACL-------------KRREEE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	19/51 (37%)
Tcf12	NP_037308.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..109
		Leucine-zipper	119..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..313		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..393		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..605		22/108 (20%)
		HLH	608..661	CDD:197674	18/52 (35%)
		Class A specific domain	657..680		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..707		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910