DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment net and Atoh1

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_031526.1	Gene:	Atoh1 / 11921	MGIID:	104654	Length:	351	Species:	Mus musculus

Alignment Length:	212	Identity:	55/212 - (25%)
Similarity:	93/212 - (43%)	Gaps:	26/212 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 HEIMPNPAHI--YVRHPGVTTLHRSLAAHPEQL------EPLALVTTKKQ--CVDQA------GP 201
            |...|.|.|:  ....|..|...|.|..:|.:|      :|.|.:|...|  |..:|      .|
Mouse    19 HHRHPQPHHVPPLTPQPPATLQARDLPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSP 83

  Fly   202 KIEAFSALLIGKQPSAKKTLKERTQKESTSSSFLEASLSDE--------DLNKTGLAPISRPHQH 258
            ::.|..|.....:..::..|..|:.....|.|.....:.::        .:::.|.:....|...
Mouse    84 ELGASEAAAPRDEADSQGELVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSK 148

  Fly   259 QRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLSKLSVLRVACSYILTLSRM 323
            |.|  .:.::||:.||||||.|:|.::.|::.||..:|::.:.:||||...|::|..||..||.:
Mouse   149 QVN--GVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSEL 211

  Fly   324 AGEDYSADQSVPSIATC 340
            .......:|..|..|:|
Mouse   212 LQTPNVGEQPPPPTASC 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	22/50 (44%)
Atoh1	NP_031526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..39		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..116		4/26 (15%)
		HLH	155..213	CDD:238036	24/57 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	61	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960