DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and CACNA1G

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_061496.2 Gene:CACNA1G / 8913 HGNCID:1394 Length:2377 Species:Homo sapiens


Alignment Length:2435 Identity:483/2435 - (19%)
Similarity:806/2435 - (33%) Gaps:903/2435 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 LNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGRKQSLKG 330
            ||.|.|.||..|.|......|.          ..:...|:|...|.                   
Human    22 LNDLSGAGGRPGPGSAEKDPGS----------ADSEAEGLPYPALA------------------- 57

  Fly   331 GEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTP-----KTFERYPSLQFI 390
              |.:..|..::|...|..:..|...|..|:..|..|::..::.:..|     ...:|...||  
Human    58 --PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQ-- 118

  Fly   391 TFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPK 455
              |.|..:...|..||:.||...|:. |:..||.|.|.:.|    .|:.|:.:|:....|:.| .
Human   119 --AFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLD----FFIVIAGMLEYSLDLQNV-S 175

  Fly   456 FSYLSIMRAPRPLIMI------RFLRVFLKFSMPKSRINQIFKRSSQQIYNVTL--FFLFFMSLY 512
            ||.:..:|..|||..|      |.|...|..::|             .:.||.|  ||:||  ::
Human   176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP-------------MLGNVLLLCFFVFF--IF 225

  Fly   513 GLLGVQFF-GELKNHCVMNNT-----EYDLYKRPILTINSLAIPDTFCSMDPDSG---------- 561
            |::|||.: |.|:|.|.:...     ..|| :|...|.|....| ..||...::|          
Human   226 GIVGVQLWAGLLRNRCFLPENFSLPLSVDL-ERYYQTENEDESP-FICSQPRENGMRSCRSVPTL 288

  Fly   562 ----------------YQCSPGMVCMKMD-FLSSYVIG----FNG---FEDIATSIFTVYQAASQ 602
                            |..|....|:..: :.::...|    |.|   |::|..:...::|..:.
Human   289 RGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITL 353

  Fly   603 EGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEI-----------RVQF- 655
            ||||.|||..:|: .::....||..:|...::.:.|:.:.||...|:|.           ||:| 
Human   354 EGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFL 417

  Fly   656 ----------------QQMWGARGHIQKTAASQI-------------------LSGNDT------ 679
                            :::.....:|.:.||.::                   |.|.:|      
Human   418 SNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSC 482

  Fly   680 ----------------------------------------------GWRLV-------------- 684
                                                          ..||:              
Human   483 SRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPP 547

  Fly   685 -----------------------------------TIDDNK------------------------ 690
                                               |:...|                        
Human   548 GGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAA 612

  Fly   691 ----------------------------------------------HGGLAPETC---------- 699
                                                          .|...|::|          
Human   613 SSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

  Fly   700 ------------------------HAILRSPY--------------------------FRMLVMS 714
                                    |:.||.|:                          ||.:|.|
Human   678 VELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDS 742

  Fly   715 VILANGIV------TATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHS 773
            .....||:      |.:|..::..:|.:: ........:|||.|..||.|.|:...|..||.|:.
Human   743 KYFGRGIMIAILVNTLSMGIEYHEQPEEL-TNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNP 806

  Fly   774 IHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLII 835
            .:.|:.::...:...||.. ...||:.   |:::||::|::..|.|:..:..:......:.:..:
Human   807 YNIFDGVIVVISVWEIVGQ-QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCM 870

  Fly   836 FTMCLLIISSSISMQLF-C---------FLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIR 890
            ..|..:.|.|.:.|.|| |         .|.|...|:|...|.:::|||||||.|.:|:...|..
Human   871 LLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAS 935

  Fly   891 TSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKK--------LKQLKFREQSAEI 947
            ||.    ..|:|||....|...::.:|.||::::..:.:|..|:        ..||....|..:.
Human   936 TSS----WAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDA 996

  Fly   948 KETLPFRLRIFEKFPD--SPQM----------------------------TILHRIPNDFMLPK- 981
            .::        |..||  ||.:                            .|:|.......||| 
Human   997 NKS--------ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1053

  Fly   982 --------------------VRESFMKHFVIELETEDSLVENCKRPMS--ECWESNVVFRKQKPV 1024
                                ..|....|   |:::..|...:...|.|  ..|.|.         
Human  1054 TSTGLGEALGPASRRTSSSGSAEPGAAH---EMKSPPSARSSPHSPWSAASSWTSR--------- 1106

  Fly  1025 RIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWR 1089
                     |::.:||.:.......:.|..:|.:|            .|.|.:||.....|:..|
Human  1107 ---------RSSRNSLGRAPSLKRRSPSGERRSLL------------SGEGQESQDEEESSEEER 1150

  Fly  1090 V-----DQKKFGSRSIRRSVRSGSIKLKQTYE----HLMENGDIAAAP------RANSGR----A 1135
            .     |.:..|  |:.|..:| |..|..|.:    |...:|..:|:.      ::.|||    .
Human  1151 ASPAGSDHRHRG--SLEREAKS-SFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1212

  Fly  1136 RPHDLDI---------KLLQAKRQQAEMRRNQ----REEDLRENHPFFDTPLFLVPRESRFRKIC 1187
            ||.|..:         .|.:.:|.:|.:|...    .|.|        ....::.|.:||||.:|
Human  1213 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERD--------SWSAYIFPPQSRFRLLC 1269

  Fly  1188 QKIV-HARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMD 1251
            .:|: |..:|                   |..|        |:||   |:||::..|.|  ::..
Human  1270 HRIITHKMFD-------------------HVVL--------VIIF---LNCITIAMERP--KIDP 1302

  Fly  1252 HPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVST-SFLCWMPL 1311
            |..    |.::.|.|......|:.:|::|.|..|..:||::.....||..:.::|. ..|..|..
Human  1303 HSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVS 1367

  Fly  1312 NIPTNSAAQL--LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQ 1374
            :..|.....|  |.:||.:||||:.:....::.||..|....|.|..:..:......||...|||
Human  1368 DSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432

  Fly  1375 LYGGRLARC---NDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDN 1436
            |:.|:...|   :...|:.:.||.                  :.||.       |.. .::||||
Human  1433 LFKGKFFVCQGEDTRNITNKSDCA------------------EASYR-------WVR-HKYNFDN 1471

  Fly  1437 IGDAMLTLFEVLSFKGWLDVRDVLIKAVG----------PVHAVYIHIYIFLGCMIGLTLFVGVV 1491
            :|.|:::||.:.|..||:|:....:.|||          |...:|...::.:.....|.:|||||
Human  1472 LGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1536

  Fly  1492 IANY----SENKGTALLTVDQRRWCDLKKRLK----------------IAQPLHLPPRPDGRKIR 1536
            :.|:    ...:.......:::|...|:|:.:                .::....|...|..:.|
Human  1537 VENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFR 1601

  Fly  1537 AFTYDI-TQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAF 1599
            ...:.: |.|.: ...|..|:.:|.:.:::. :.:.::..|.|.|.:.:.|.:||:|.|.|.:||
Human  1602 LLVHHLCTSHYL-DLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAF 1665

  Fly  1600 TPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTV 1664
            ..|.::|.|.|:.||.:.:..::.|.|:.|   :::........|:|...:......||:|.:.|
Human  1666 GFRRFFQDRWNQLDLAIVLLSIMGITLEEI---EVNASLPINPTIIRIMRVLRIARVLKLLKMAV 1727

  Fly  1665 GV-----SVCKSFFIIFG---MFLLVFF-YALAGTILFGTVKYG-----EGIGRRANFGSPVTGV 1715
            |:     :|.::...:..   :|:|:|| :|..|..|||.::..     ||:||.|.|.:.....
Human  1728 GMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAF 1792

  Fly  1716 AMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAI 1780
            ..|||:.||::||.||.|        ||.:...|:.|.|...|.|||.:|.:...::::|:::|:
Human  1793 LTLFRVSTGDNWNGIMKD--------TLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849

  Fly  1781 IMENFSLFYSN---EEDALLSYADIRNFQNT--------------WNIVD--------------- 1813
            :|::  |..||   :|:|.|. |::.....|              |..|:               
Human  1850 LMKH--LEESNKEAKEEAELE-AELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHP 1911

  Fly  1814 -IHQRGVI------PVRRVKF--ILRLLKGRLE---------------------------CDPQ- 1841
             .|.|...      |..|..|  |..|::|.||                           .||| 
Human  1912 AAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQI 1976

  Fly  1842 ------------------------------------------------------KDRLLFK---- 1848
                                                                  .|.|..:    
Human  1977 PLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGV 2041

  Fly  1849 ----------YMC--------------YELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELL 1889
                      |||              :.|.|..:|..::.|.       :..|....|||.   
Human  2042 SRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHS-------QPADTSYILQLP--- 2096

  Fly  1890 AREEFEYLVEEEVAKMTIRTWLEGCLKKI-------RAQNASKQQNSLIAGLRATNEQPVMRPNI 1947
              ::..:|::...|.    ||  |.:.|:       .||...::|    |.:| |:...|.....
Human  2097 --KDAPHLLQPHSAP----TW--GTIPKLPPPGRSPLAQRPLRRQ----AAIR-TDSLDVQGLGS 2148

  Fly  1948 QEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTF---SSTENEEKDGSSSAVVQLPHSETSI 2009
            :||              :...|:|..||.:.|:|  |   |||:.::...|        ||:.| 
Human  2149 RED--------------LLAEVSGPSPPLARAYS--FWGQSSTQAQQHSRS--------HSKIS- 2188

  Fly  2010 AGTGSSATGAATATGTSSGLGVGPPTVQST 2039
                ...|..|...|.....|.|||..:|:
Human  2189 ----KHMTPPAPCPGPEPNWGKGPPETRSS 2214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 84/344 (24%)
Ion_trans 734..927 CDD:278921 56/205 (27%)
Ion_trans 1240..1497 CDD:278921 70/280 (25%)
Ion_trans 1571..1793 CDD:278921 69/238 (29%)
CACNA1GNP_061496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 9/35 (26%)
I 68..398 88/357 (25%)
Ion_trans 130..406 CDD:278921 76/299 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 2/29 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..600 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..720 4/20 (20%)
II 729..967 64/243 (26%)
Ion_trans 760..968 CDD:278921 57/213 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1012 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1230 40/218 (18%)
III 1263..1540 85/334 (25%)
Ion_trans 1293..1547 CDD:278921 70/281 (25%)
IV 1596..1854 73/271 (27%)
Ion_trans 1628..1851 CDD:278921 65/233 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1878..1917 3/38 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2129 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2171..2244 15/57 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2272..2377
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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