DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and CACNA1H

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_006721026.1	Gene:	CACNA1H / 8912	HGNCID:	1395	Length:	2358	Species:	Homo sapiens

Alignment Length:	2421	Identity:	476/2421 - (19%)
Similarity:	780/2421 - (32%)	Gaps:	905/2421 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 GSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADI------------ 350
            |.||:.|..|...|..   |.:...|.:..:...|...|:.|.|...:|...:
Human    21 GPAALVGASPESPGAP---GREAERGSELGVSPSESPAAERGAELGADEEQRVPYPALAATVFFC 82

  Fly   351 --------EWVNKL----WVRRLMRLCALVSLTSVSLNTPKT-----FERYPSLQFITFASDTAV 398
                    .|..:|    |...:..|..:::..::.:..|..     .||...|:    |.|..:
Human    83 LGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILE----AFDAFI 143

  Fly   399 TLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMR 463
            ...|..||:.||...| |.|:..||.|.|.:.|..:|....:...|....|     ..|.:..:|
Human   144 FAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV-----SLSAIRTVR 202

  Fly   464 APRPLIMI------RFLRVFLKFSMPKSRINQIFKRSSQQIYNVTL--FFLFFMSLYGLLGVQFF 520
            ..|||..|      |.|...|..::|             .:.||.|  ||:||  ::|::|||.:
Human   203 VLRPLRAINRVPSMRILVTLLLDTLP-------------MLGNVLLLCFFVFF--IFGIVGVQLW 252

  Fly   521 -GELKNHC------VMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQ-CS--PGM------- 568
             |.|:|.|      |.||..  .:.||.............||...|:|.| ||  ||.
Human   253 AGLLRNRCFLDSAFVRNNNL--TFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPC 315

  Fly   569 ------------------------------VCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQE 603
                                          ||...|  |:...|...|::|..:...::|..:.|
Human   316 TLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGD--SNPHNGAINFDNIGYAWIAIFQVITLE 378

  Fly   604 GWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQM---------- 658
            |||.|||..:|: .::....||..:|...::.:.|:.:.||...|:|.:.:..|:
Human   379 GWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442

  Fly   659 ---------------------------------------WGAR---------------GHIQK-- 667
                                                   |.:|               ||.|:
Human   443 NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRA 507

  Fly   668 ----------------------------------------------------------------- 667

Human   508 GRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESV 572

  Fly   668 ------------------------TAASQI----------------------------------- 673
                                    |||:.:
Human   573 HSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWA 637

  Fly   674 ----------------------------------------------------------------- 673

Human   638 GGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPY 702

  Fly   674 -----------LSGNDTG---WRLV--TIDDNKHG---------------GLAPET--------- 698
                       |||:::|   .|.|  ...|.:||               |..|.:
Human   703 CTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRA 767

  Fly   699 ------------------CHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI 745
                              ...|:.|.||...:|..||.|   |.:|..::..:|.:: .......
Human   768 APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVN---TLSMGVEYHEQPEEL-TNALEIS 828

  Fly   746 ELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVV 807
            .:|||.:..||.|.|:...|..||.::..:.|:.::...:...||.. ...||:.   |::|||:
Human   829 NIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-ADGGLSVLRTFRLLRVL 892

  Fly   808 RLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDFT------------- 859
            :|::..|.|...:..:......:.:.....|..:.|.|.:.|.||.  |.|:
Human   893 KLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG--CKFSLKTDTGDTVPDRK 955

  Fly   860 KFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILD 924
            .|:|...|.:::|||||||.|..|:...|..||.    ..|:||:....|...::.:|.||::::
Human   956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS----WAALYFVALMTFGNYVLFNLLVAILVE 1016

  Fly   925 ------------------NLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILH 971
                              ::..:||..||::|    |:.|:|                  |..|.
Human  1017 GFQAEGDANRSDTDEDKTSVHFEEDFHKLREL----QTTELK------------------MCSLA 1059

  Fly   972 RIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036
            ..||.                .||...||    ..|:..|..:.       |:.....:..:.||
Human  1060 VTPNG----------------HLEGRGSL----SPPLIMCTAAT-------PMPTPKSSPFLDAA 1097

  Fly  1037 GSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIR 1101
            .|          :.||.......||.   |:...|....|:|    :...||...    |:.|.|
Human  1098 PS----------LPDSRRGSSSSGDP---PLGDQKPPASLRS----SPCAPWGPS----GAWSSR 1141

  Fly  1102 RSV-----RSGSIKL---------------KQTYEHLMENGDIAAAPRANSGR------------ 1134
            ||.     |:.|:|.               |.:.:...|:|..|..|||...|
Human  1142 RSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRP 1206

  Fly  1135 ----------------ARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDT----------- 1172
                            |.|.|..:::...:...||:..:..:......|...:.
Human  1207 AALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREA 1271

  Fly  1173 -PLFLVPRESRFRKICQKIV-HARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTL 1235
             .|:|...::|||..|||:: |..:|                   |..|        |.||   |
Human  1272 WALYLFSPQNRFRVSCQKVITHKMFD-------------------HVVL--------VFIF---L 1306

  Fly  1236 SCISMMFETPNY------RVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAAL 1294
            :|:::..|.|:.      ||.    |.::.|.|......|:.:|::|.||.....||::.....|
Human  1307 NCVTIALERPDIDPGSTERVF----LSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLL 1367

  Fly  1295 DVFIYVVSTSFLCWMPLNIPTNSAA--------QLLMILRCVRPLRIFTLVPHMRKVVYELCRGF 1351
            |..:.:||.     :.:.:...||.        ::|.:||.:||||:.:..|.::.||..|....
Human  1368 DGLLVLVSL-----VDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL 1427

  Fly  1352 KEILLVSTLLILLMFIFASYGVQLYGGRLARCNDP---TISRREDCVGVFMRRVFVTKMKLTPGP 1413
            :.|..:..:......||...||||:.|:...|..|   .||.:..|.....|
Human  1428 RPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYR------------- 1479

  Fly  1414 DESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG----------PVH 1468
                        |.. |::||||:|.|:::||.:.|..||:::....:.|||          |..
Human  1480 ------------WVR-RKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWM 1531

  Fly  1469 AVYIHIYIFLGCMIGLTLFVGVVIANYSE------------NKGTALLTVDQRRWCDLKKRLKIA 1521
            .:|...::.:.....|.:|||||:.|:.:            .:...|..:::||   ..|.|.:|
Human  1532 LLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRR---RSKALPVA 1593

  Fly  1522 --------QPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERL 1577
                    :|.:....|..|.|.:.   .|.|.: ...|..::.:|.:.:|:. :.:.:...|.|
Human  1594 VAVAEAQRRPYYADYSPTRRSIHSL---CTSHYL-DLFITFIICVNVITMSMEHYNQPKSLDEAL 1654

  Fly  1578 VIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMV 1642
            ...:.|.|.|||.|..:|.:||..|.:::.|.|:.||.:.:..::.|.|:.|   ::|.......
Human  1655 KYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEI---EMSAALPINP 1716

  Fly  1643 VILRFFTITGKHTTLKMLMLTVGVSVCKSFFI--------IFGMFLLVFF-YALAGTILFGTVKY 1698
            .|:|...:......||:|.:..|:.......:        :..:|:|:|| ||..|..|||.::.
Human  1717 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLEC 1781

  Fly  1699 G-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTAS 1758
            .     ||:.|.|.|.:.......|||:.||::||.||.|.:.:   |:..:.:    |.::..:
Human  1782 SEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRE---CSREDKH----CLSYLPA 1839

  Fly  1759 L--IYFCTFYVIITYIVLNLLVAIIMENFSLFYSNE---EDALLSYADIRNFQNTWNIVDIHQRG 1818
            |  :||.||.::..::::|::||::|::  |..||:   |||.|. |:|.
Human  1840 LSPVYFVTFVLVAQFVLVNVVVAVLMKH--LEESNKEAREDAELD-AEIE--------------- 1886

  Fly  1819 VIPVRRVKFILRLLKG-----RLECD----PQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSY 1874
                      |.:.:|     |::.|    ||                   |.....|..|:::
Human  1887 ----------LEMAQGPGSARRVDADRPPLPQ-------------------ESPGARDAPNLVA- 1921

  Fly  1875 RSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNE 1939
            |.|.:.:.|.|                                   .|.|.....::.. .|.:.
Human  1922 RKVSVSRMLSL-----------------------------------PNDSYMFRPVVPA-SAPHP 1950

  Fly  1940 QPVMRPNIQEDKA--PLGAVDK---------------SAIST--ISGAVAGACPPTSDAFSPTFS 1985
            :|:....::...|  |||:|..               .|:|:  .||....|..|...|.||:.|
Human  1951 RPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLS 2015

  Fly  1986 -------STENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGP----PTVQST 2039
                   :...:..:|.    :..|......|..|..........|.|  |...|    |....|
Human  2016 RLLCRQEAVHTDSLEGK----IDSPRDTLDPAEPGEKTPVRPVTQGGS--LQSPPRSPRPASVRT 2074

  Fly  2040 ARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPH 2104
            .:|  |.|:|..:...:...|..|       .:|||      :|:|..||||....... |..||
Human  2075 RKH--TFGQRCVSSRPAAPGGEEA-------EASDP------ADEEVSHITSSACPWQP-TAEPH 2123

  Fly  2105 AGQLGQLAKQRGGGGE 2120
            ..:...:|     |||
Human  2124 GPEASPVA-----GGE 2134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	85/340 (25%)
		Ion_trans	734..927	CDD:278921	53/226 (23%)
		Ion_trans	1240..1497	CDD:278921	70/283 (25%)
		Ion_trans	1571..1793	CDD:278921	65/240 (27%)
CACNA1H	XP_006721026.1	Ion_trans	149..430	CDD:278921	78/306 (25%)
		Ion_trans	810..1019	CDD:278921	54/216 (25%)
		Ion_trans	1317..1565	CDD:278921	68/282 (24%)
		Ion_trans	1639..1852	CDD:278921	59/222 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920