DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and CACNA1I

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2421 Identity:475/2421 - (19%)
Similarity:829/2421 - (34%) Gaps:846/2421 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   294 SSTVGSAAITGV-------------PPIGLGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESL- 344
            ||....||..||             ||               |.::.|.|.:|.:    |...| 
Human    10 SSAAAPAAEPGVTTEQPGPRSPPSSPP---------------GLEEPLDGADPHV----PHPDLA 55

  Fly   345 --------NESADIEWVNKL----WVRRLMRLCALVSLTSVSLNTP-----KTFERYPSLQFITF 392
                    ..::...|..|:    |...:..|..|::..::.:..|     ...:|...||..  
Human    56 PIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVF-- 118

  Fly   393 ASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFD-----ASMVSFLWISIILQIFEVLEI 452
              |..:.:.|..||:.||...|:. |:..||.|.|.:.|     |.||.:   |:.||...:   
Human   119 --DDFIFIFFAMEMVLKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEY---SLDLQNINL--- 174

  Fly   453 VPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI-NQIFKRSSQQIYNVTL--FFLFFMSLYGL 514
                |.:..:|..|||..|.        .:|..|| ..:...:...:.||.|  ||:||  ::|:
Human   175 ----SAIRTVRVLRPLKAIN--------RVPSMRILVNLLLDTLPMLGNVLLLCFFVFF--IFGI 225

  Fly   515 LGVQFF-GELKNHCVMNNTEYDLYKRPILTI-NSLAIPDTF-----------CSMDPDSGY---- 562
            :|||.: |.|:|.|.:...         .|| ..:|:|..:           ||:..|:|.    
Human   226 IGVQLWAGLLRNRCFLEEN---------FTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCH 281

  Fly   563 ----------QCSPGMVCMKMDFLSSYVIG----------------FN--------------GFE 587
                      :|     |:..|.:..:..|                :|              .|:
Human   282 EIPPLKEQGREC-----CLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFD 341

  Fly   588 DIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIR 652
            :|..:...::|..:.||||.|||..:|: .::....||..:|...::.:.|:.:.||...|:|.:
Human   342 NIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETK 405

  Fly   653 VQ---------------------------FQQMWGARGHIQKTAASQILS--------------- 675
            .:                           :::::....||.:.|..:.|.               
Human   406 QREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPE 470

  Fly   676 ---------------------------------------------GNDTGWR------------- 682
                                                         |||...|             
Human   471 APAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATP 535

  Fly   683 -------------------------------LVTIDDNKHG-----------------------G 693
                                           |.:.|..:.|                       |
Human   536 HTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 600

  Fly   694 LAPE----------------TC-----------HAILRSPYFRMLVMSVILANGIVTATMTFKHD 731
            .:.|                .|           ..|:.|.||...:|..||.|   |.:|..:|.
Human   601 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVN---TVSMGIEHH 662

  Fly   732 GRPRDV--FYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFY 794
            .:|.::  ..|   ...:|||.:..||.:.|:...|...|.::..:.|:.::...:...||.. .
Human   663 EQPEELTNILE---ICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQ-A 723

  Fly   795 PSGLTY---FQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLC 856
            ..||:.   |::|||::|::..|.|...:..:......:.:..:..|..:.|.|.:.|.:|.  |
Human   724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG--C 786

  Fly   857 DFT-------------KFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHL 908
            .|:             .|:|...|.:::|||||||.|..|:...|..||    |..::||:....
Human   787 KFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS----PWASLYFVALMT 847

  Fly   909 FVTLIVLSLFVAVILDNLEL---------DEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPD- 963
            |...::.:|.||::::..:.         |||          :.|:.|:|        |:|..: 
Human   848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDED----------QSSSNIEE--------FDKLQEG 894

  Fly   964 -----SPQMTILHRIPNDFMLPKV----------------RESFMKH-FVIELETEDSLVENCKR 1006
                 .|::..:...||..:.|.:                |.|.... .::.|.:..|.|.:..|
Human   895 LDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGR 959

  Fly  1007 -------------------PMSECWES-----NVVFRKQKPVRIMNKT--AKVRAAGSSLRKLAI 1045
                               ..|..|.|     |.:  |.||....:::  :..|..|:.:.::|.
Human   960 MSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL--KHKPPSAEHESLLSAERGGGARVCEVAA 1022

  Fly  1046 ---------------------THIINDSNNQRLMLG----DSA----MLPVVGTKGGGGLKSQGT 1081
                                 .|:.:...:.|..|.    ||.    ::|.||            
Human  1023 DEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVG------------ 1075

  Fly  1082 ITHSK-PWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLL 1145
             .|.: .||......|....  :.|..|| .|..:..:.:.||     |...    ..::|..|.
Human  1076 -AHPRAAWRAAGPAPGHEDC--NGRMPSI-AKDVFTKMGDRGD-----RGED----EEEIDYTLC 1127

  Fly  1146 QAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIV-HARYDARLKDPLTGKERK 1209
            ...|:..::.:....| :||     |..::|...|:|||.:||.|: |..:|             
Human  1128 FRVRKMIDVYKPDWCE-VRE-----DWSVYLFSPENRFRVLCQTIIAHKLFD------------- 1173

  Fly  1210 VQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRV--MDHPTLQIAEYGFVIFMSLELAL 1272
                          |:....||   |:||::..|.|....  .:...|.::.|.|......|:.|
Human  1174 --------------YVVLAFIF---LNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTL 1221

  Fly  1273 KILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAA----------QLLMILRC 1327
            |:::.||:|..:||::.....||.|:..||.       ::|..:.|:          ::|.:||.
Human  1222 KVVSLGLYFGEQAYLRSSWNVLDGFLVFVSI-------IDIVVSLASAGGAKILGVLRVLRLLRT 1279

  Fly  1328 VRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARC---NDPTIS 1389
            :||||:.:..|.::.||..|....|.|..:..:......||...||||:.|:...|   :...|:
Human  1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNIT 1344

  Fly  1390 RREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWL 1454
            .|.||:....|                         |.: .::||||:|.|:::||.:.|..||:
Human  1345 NRSDCMAANYR-------------------------WVH-HKYNFDNLGQALMSLFVLASKDGWV 1383

  Fly  1455 DVRDVLIKAV----------GPVHAVYIHIYIFLGCMIGLTLFVGVVIANY----SENKGTALLT 1505
            ::....:.||          .|...:|...::.:.....|.:|||||:.|:    ...:......
Human  1384 NIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448

  Fly  1506 VDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDI-TQHI--IFKRVIAVVVLINSMLLSITW 1567
            .:::|...|:|:.:.||  .||........|...:.: |.|.  ||   |..::.:|.:.:|:..
Human  1449 REEKRLRRLEKKRRKAQ--RLPYYATYCHTRLLIHSMCTSHYLDIF---ITFIICLNVVTMSLEH 1508

  Fly  1568 IKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILR 1631
            .......| .|...:.:.|.|||:|.|:|.:||..|.:::.|.|:.||.:.:..|:.|.|:.|  
Human  1509 YNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEI-- 1571

  Fly  1632 NDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFI--------IFGMFLLVFF-YAL 1687
             :::........|:|...:......||:|.:..|:.......:        :..:|:|:|| ||.
Human  1572 -EINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAA 1635

  Fly  1688 AGTILFGTVKYG-----EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNY 1747
            .|..|||.:...     ||:.|.|.|.:.......||::.||::||.||.|.:..   ||    :
Human  1636 LGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD---CT----H 1693

  Fly  1748 WETDCGNFTASL-----IYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEE-------DALLS-- 1798
            .|..|   .:||     :||.:|.:...::::|::||::|::  |..||:|       ||.|.  
Human  1694 DERSC---LSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH--LDDSNKEAQEDAEMDAELELE 1753

  Fly  1799 ----------------------------------------YADIRNFQNTWNIVDIHQRGVIPVR 1823
                                                    |:..:  :|.|            :.
Human  1754 MAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQ--ENLW------------LD 1804

  Fly  1824 RVKFILR-LLKGRL---------------------ECDPQKDRL-LFKYMCYELDKLHN-----G 1860
            .|..|:: .|:|.|                     :|...|..: |.:...:.|:...:     |
Human  1805 SVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLG 1869

  Fly  1861 EDVTFHDVI-----NMLSYRSVDIRKALQLEEL-----------LAREEFEYLVE-EEVAKMTIR 1908
            :|::..|..     ...|...:|..:.:::.:|           ::.:...:|.| ||:....:|
Human  1870 DDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVR 1934

  Fly  1909 TWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGAC 1973
            :||             |..:|                     :||.......|.|.:       .
Human  1935 SWL-------------KHDSS---------------------QAPPSPFSPDASSPL-------L 1958

  Fly  1974 PPTSDAFSPTFSSTENEEKDGSSSAV---VQLPHSETSIAGTGSSATGAATATGTSSGLGVGPP- 2034
            |..::.|.|..|:::...:.|:.:..   :.|..|..|:.....:.|....|||:.:.|...|. 
Human  1959 PMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSS 2023

  Fly  2035 ---TVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKK 2096
               ::|:|....:|:         |||.     |:.|.|.:..|..|:.||...|..::.:.|..
Human  2024 SAGSLQTTLEDSLTL---------SDSP-----RRALGPPAPAPGPRAGLSPAARRRLSLRGRGL 2074

  Fly  2097 NSMTTLPHAGQLGQLAKQR--GGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGH 2159
            .|:.        |..|.||  ..||..:.            |..|:.:::.:            .
Human  2075 FSLR--------GLRAHQRSHSSGGSTSP------------GCTHHDSMDPS------------D 2107

  Fly  2160 GHGHGGHGGHGGHGEH 2175
            ..|.||.||.|...||
Human  2108 EEGRGGAGGGGAGSEH 2123

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 79/350 (23%)
Ion_trans 734..927 CDD:278921 51/210 (24%)
Ion_trans 1240..1497 CDD:278921 69/285 (24%)
Ion_trans 1571..1793 CDD:278921 66/241 (27%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 11/50 (22%)
I 66..401 82/374 (22%)
Ion_trans 127..409 CDD:278921 73/317 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 4/68 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 5/60 (8%)
II 626..865 62/251 (25%)
Ion_trans 657..866 CDD:278921 53/218 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 4/36 (11%)
III 1157..1434 82/339 (24%)
Ion_trans 1202..1441 CDD:278921 67/271 (25%)
IV 1472..1733 71/278 (26%)
Ion_trans 1504..1741 CDD:278921 68/251 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 0/25 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 7/63 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 15/62 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 17/80 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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