Protein Alignment na and CCH1

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 1756
• Identity: 367/1756 - (20%)
• Similarity: 690/1756 - (39%)
• Gaps: 460/1756 - (26%)

  Fly   422 YLKDHWCQFD-ASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLR-VFLKFSMPK 484
            :.:..|.:.| .|.||| |:.:.|.|       ..:...:.:|..:||.::|.|| |.:...||.
Yeast   489 FARSSWNRIDLVSSVSF-WLGMFLSI-------KSYDTKTGIRIFKPLAILRILRLVNVDTGMPS 545

  Fly   485 SRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTE-------YDLYKRPI 541
              |.:..|....|:.||:...::|...:|:||||.| |..:..||..|.|       ||:
Yeast   546 --ILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDM----- 603

  Fly   542 LTINSLAIPDTFCS--MDP----------DSGYQ--CSPGMVCMKMDFLSSYVIGFNG---FEDI 589
                      .||.  :||          :.|.:  .|.|.:|.:.....|....:||   |::|
Yeast   604 ----------QFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSKCVSNANPYNGRISFDNI 658

  Fly   590 ATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLA-WLVKNVFIAVITETFNEIRV 653
            ..|:..|:...|...:..:||..:|| ....|..:|...||.|. ||: |:.|||:..:|.....
Yeast   659 VNSMELVFVIMSANTFTDLMYYTMDS-DEMAACLFFIVCIFVLTIWLL-NLLIAVLVSSFEIANE 721

  Fly   654 QFQQ---MWGARGHIQKTA-ASQILSGNDTGWRLVTIDDNKHGGLAPETCHAILRSPYFRMLVMS 714
            ::::   ::|:|    ||. .::|::|.   |:                        ||::....
Yeast   722 EYKKKKFIYGSR----KTGYVARIVTGY---WK------------------------YFKLKANQ 755

  Fly   715 VILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYC-LGWRGYYK--HSIHK 776
            ....|........:.|              :|.:|..|        |.| :|.|...|  .|.:.
Yeast   756 TKFPNWSQKGLAIYSH--------------VEFIFVIL--------IICDIGMRASVKVSTSANC 798

  Fly   777 FELLLAAGTTLHIV---------PMFYPS--------GLTYFQVLRVVRLIKASPMLEGFV---- 820
            ..:||.....:.||         .::.|:        ...|..::.::.|:.:...:||.:
Yeast   799 NNILLKTDRGISIVLFIESLARLVLYLPNMWKFLTKPSYVYDFIISIITLVISCLAVEGVLGHMY 863

  Fly   821 -----------YKI---FGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF---TKFE------ 862
                       |::   |...|||...|:....::...||... .|.||...   ..||
Yeast   864 AWLSIFHISRFYRVIISFNLTKKLWKQILSNGVMIWNLSSFYF-FFTFLVAIIMAVYFEGVIPPE 927

  Fly   863 ----------SFPEAFMSMFQILTQEAWVEVMDETMIRTSKTL--TPLVAVYFILYHLFVTLIVL 915
                      |.|.:|:|:|.|.:.|.|.::: ..:.:.|..:  |...:|:||::.|....::|
Yeast   928 EMADQPFGMYSLPNSFLSLFIIGSTENWTDIL-YALQKHSPNISSTFFCSVFFIIWFLLSNSVIL 991

  Fly   916 SLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLP 980
            ::|:|:|.:::|:.|:.|:.:|:|.     .:|...|      :|..:....:::.||...|...
Yeast   992 NIFIALISESMEVKEEEKRPQQIKH-----YLKFVYP------QKIQEYTHASLVARIRKKFFGG 1045

  Fly   981 KVRESF--MKHFVIE-------LETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036
            ...|..  .|.|::.       .:....|.:..|.|.||     .:|:|        ..:|:...
Yeast  1046 HRNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPPSE-----NLFKK--------GLSKLTIG 1097

  Fly  1037 GSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIR 1101
            ..||::|.:.     :||.
Yeast  1098 VPSLKRLRMF-----ANNP---------------------------------------------- 1111

  Fly  1102 RSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREE---DL 1163
                            ..:|.|:... ..|....|.:.|::              |:.|:   |.
Yeast  1112 ----------------FYKNSDVVFT-ETNDINGRTYILEL--------------NEYEDEKLDY 1145

  Fly  1164 RENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERK-----VQYKSLHNFLGLVT 1223
            .:.:|.|:...:....:.|||:.||::|         .|.|||...     .....|:|......
Yeast  1146 LKKYPLFNYSYYFFSPQHRFRRFCQRLV---------PPSTGKRTDGSRFFEDSTDLYNKRSYFH 1201

  Fly  1224 YLD---WVMIF--ATTLSCISMMFETPNYRVMDHPT-----LQIAEYGFVIFMSLELALKILADG 1278
            :::   :|.||  ||.|..:...:.||.|| |.|..     ....:..|:...|:|..:|.:|||
Yeast  1202 HIERDVFVFIFALATILLIVCSCYVTPLYR-MHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADG 1265

  Fly  1279 LFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMI---LRCVRPLRIFTLVPHM 1340
            ..::|.||:::....:| |..::|    .|:.|.....:...|..|   |..:|.||..|:....
Yeast  1266 FIYSPNAYLRNPWNFID-FCVLIS----MWINLIAYLKNNGNLSRIFKGLTALRALRCLTISNTA 1325

  Fly  1341 RK----VVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRR 1401
            |:    |:::   |..:|.....:.:.|:|.|..:|:.::.|||..|||.::. |.||...:...
Yeast  1326 RQTFNLVMFD---GLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGSLG-RADCYNEYSNS 1386

  Fly  1402 VFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG- 1465
            ||...             ::.|||:..| ..:.|:...|..:|::::|.:||:|:.:.::.:.|
Yeast  1387 VFQWD-------------IMSPRVYQQP-YLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGI 1437

  Fly  1466 --PV-------HAVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKRLKIA 1521
              |.       :|:::.::.||..:..|.|||..::.|.:...|:|..|::::.|.:.:|.|..|
Yeast  1438 GTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQKLLSQA 1502

  Fly  1522 QPLHLPPRPDGRKIRAFTYDIT---QHIIFKRVIAVVVLIN-SMLLSITWIKGEVHTERLVIVSA 1582
            :|..:|...:..::|.|.|.:.   ::..:...:.||:.:: .||||.::..|     .|:....
Yeast  1503 KPKAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSYNPG-----NLIGYQG 1562

  Fly  1583 VL----TFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFF----- 1638
            |.    |.||:::..:......||.|::.:.|...|.:.:  :.:|:.........|:::
Yeast  1563 VYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIII--IAFIMNAVAFHVPASHYWFHNIK 1625

  Fly  1639 GFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIG 1703
            ||.:::: |..|..::.||..|:.|...|:.....:.:...:|...||:|...:||..:.|....
Yeast  1626 GFFLLVI-FLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGSNTT 1689

  Fly  1704 RRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVI 1768
            ...||.:.:..:.:|||...||.||.||.|..|..|||:..:|...||||:.|.:.:...::.:|
Yeast  1690 DNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSDDNSTYTDCGSETYAYLLLMSWNII 1754

  Fly  1769 ITYIVLNLLVAIIMENFSLFY-SNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFIL--- 1829
            ..||.:|:.|::|:.|||..| |....:.::.::|:.:...|:..|....|.:.:..:..|:
Yeast  1755 SMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSF 1819

  Fly  1830 ------RLLKGRL----------ECDP--------------------QKDRLLFKYMCYE--LDK 1856
                  ::.:|||          |.:|                    .|.:::.:.:.|.  :..
Yeast  1820 DGPLSFKIWEGRLTIKSLVENYMEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQRKLQYRRFVQS 1884

  Fly  1857 LH-----NGEDVTFHDVINMLS-YRSVDIRKALQLEE------LLAREEFEYLVEE---EVAKMT 1906
            :|     || .:.|.|::..:. |.:...|:.|.:::      :|.:.: :||..:   :|.:|.
Yeast  1885 IHYTNAYNG-CIRFSDLLLQIPLYTAYSARECLGIDQYVHHLYILGKVD-KYLENQRNFDVLEMV 1947

  Fly  1907 IRTWLEGCLKK--------IRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAIS 1963
            :..|...|..|        ::....|...:::               |:..:.|| |.:::..|:
Yeast  1948 VTRWKFHCRMKRTIEPEWDVKDPTVSSHISNI---------------NVNLEPAP-GILEREPIA 1996

  Fly  1964 T 1964
            |
Yeast  1997 T 1997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	69/259 (27%)
		Ion_trans	734..927	CDD:278921	49/251 (20%)
		Ion_trans	1240..1497	CDD:278921	68/278 (24%)
		Ion_trans	1571..1793	CDD:278921	61/231 (26%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:395416	69/259 (27%)
		Ion_trans	769..1010	CDD:395416	52/264 (20%)
		Ion_trans	1210..1480	CDD:395416	73/293 (25%)
		Ion_trans	1529..1776	CDD:395416	66/254 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004135
OrthoInspector	1	1.000	-	-		oto99355
orthoMCL	1	0.900	-	-		OOG6_104443
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840