DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and scn8ab

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_005166128.1 Gene:scn8ab / 793996 ZFINID:ZDB-GENE-060906-2 Length:1969 Species:Danio rerio


Alignment Length:2117 Identity:415/2117 - (19%)
Similarity:746/2117 - (35%) Gaps:684/2117 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GEPFLADYG--PEESLN---ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERY---PSL 387
            |.||:  ||  |...|.   |..|..::||              .|.:.||..||..|:   |||
Zfish    66 GVPFI--YGDVPSNMLAVPLEDLDPFYLNK--------------KTFIVLNKGKTIFRFSATPSL 114

  Fly   388 Q----------------------------------FITFAS--------DTAVTLLFTAEMIAKM 410
            .                                  |:||::        :...|.::|.|.:.|:
Zfish   115 YIISPFNLFRQIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLTKI 179

  Fly   411 HIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLR 475
            ..||....:..:|:|.|...|..::|..:|:             :|..|..:.|.|...::|.|:
Zfish   180 VARGFCIDDFTFLRDPWNWLDFMVISMAYIT-------------EFVNLGNVSALRTFRVLRALK 231

  Fly   476 VFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCV---MNNTE--- 533
            ........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:..||   :|:||   
Zfish   232 TVAVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPVNSTETYL 295

  Fly   534 ------YDLYKRPILTINSLAIPD----TFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFED 588
                  :|..:..:...|...:|.    ..|....||| :|..|..|||.....:|  |:..|:.
Zfish   296 ANGSKGFDFNEYIMNDTNFYFLPGMLDALLCGNSSDSG-RCPEGYTCMKAGRNPNY--GYTSFDS 357

  Fly   589 IATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETF 648
            ...:...:::..:|:.|..:....:      |||     .:|..:||..::.:.|:.:||:...:
Zfish   358 FGWAFLALFRLMTQDFWENLYQLTL------RAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAY 416

  Fly   649 N---------------EIRVQFQQMWGAR-------------------------GHIQKTAA--- 670
            .               |.:...:|:...:                         ||:.::::   
Zfish   417 EEQNQATIEEAEQKEAEFKAMLEQLKKQQEEAQANAMATSAGTVSEDAVEDDGGGHLSRSSSEVS 481

  Fly   671 ----------------------------------------------------------------- 670
                                                                             
Zfish   482 KLSSKSAKERRNRKKKWRKEQEEKGDSEKVVKSESDDGSKRSRFRFRDNRLGRKASIMNQSLLSI 546

  Fly   671 ---------SQILS--GND------------------------------TGW------------- 681
                     |.|.|  |::                              :|:             
Zfish   547 PGSPFMSRRSSIFSFKGSENEFADDEHSTVEESEDRRGSLFVPYRRSSYSGYSQGSSRINPLAPH 611

  Fly   682 ----RLVTIDDN-----------------------------------KHGG-------------- 693
                |..|:|.|                                   ||.|              
Zfish   612 PGCKRNSTVDCNGVVSLIGPGPGRLLPEVKIDKAASDDSTTEVEGKRKHSGSLMVSVDQLNTSFS 676

  Fly   694 --------------------------------------LAPETC----------HAILRSPYFRM 710
                                                  |..|.|          :.|:..|:..:
Zfish   677 RKERANSAMTVVTNTLVEELEESQRKCPPCWYKFANTFLIWECCPIWIKIKEIVNLIVMDPFVDL 741

  Fly   711 LVMSVILANGIVTATMTFKH-DGRPRDVFYERYYYIELVFTCLLDLETLFKIYCL--------GW 766
            .:...|:.|   |..|..:| ...||  |.|......||||.:...|...|:..:        ||
Zfish   742 AITICIVLN---TVFMAMEHYPMTPR--FEEVLSVGNLVFTGIFTAEMFAKLIAMDPYYYFQEGW 801

  Fly   767 RGY--YKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-K 828
            ..:  :..|:...||.||....|.:        |..|::|||.:|.|:.|.| ..:.||.|.. .
Zfish   802 NIFDGFIVSLSLVELGLADVEGLSV--------LRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVG 857

  Fly   829 KLGSLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF--ESFPEAFMSMFQILTQEAW 880
            .||:|.:....::.|.:.:.||||        |.:   |:..::  ..|..:|:.:|::|..| |
Zfish   858 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAESCELPRWHMNDFFHSFLIVFRVLCGE-W 921

  Fly   881 VEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNLELDEDIKKLKQLKF 940
            :|.|.:.|....:::..:|   |::..:...|:||:||:|::|     |||...:|..::..|:.
Zfish   922 IETMWDCMEVAGQSMCLIV---FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQI 983

  Fly   941 REQSAEIKETLP-FRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENC 1004
              ....||:.:. |::.:        ::.:.|      :|.|.          .||.||      
Zfish   984 --SVIRIKKGIAWFKIHV--------RLLVAH------VLKKK----------PLEDED------ 1016

  Fly  1005 KRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVG 1069
             :|:.:.::                           :||   :::.:.....:..||     :..
Zfish  1017 -KPLDDMYD---------------------------KKL---NLMGNHTGVEIKCGD-----LNY 1045

  Fly  1070 TKGGGGLKSQGTITHSKPWRVDQKKFG-----SRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPR 1129
            .|.|.|..| |..:....:.:|::...     :.::|..:..|    :..:|:|......:.:..
Zfish  1046 PKNGNGTTS-GIGSSVGKYMIDEEPMSFIHNPNLTVRVPIAVG----ESDFENLNTEDFSSESDV 1105

  Fly  1130 ANSGRARPHDLDI------KLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQ 1188
            .||     .|||.      ..:..|..:.||...:..|:            :|.| |:.:...|.
Zfish  1106 ENS-----KDLDDTSSSEGSTIDIKPDEEEMAVVEVVEE------------YLDP-EACWTDACV 1152

  Fly  1189 KIVHARYDARLKDPLT---GKE----RKVQYKSL-HNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
                |||.. ...|:|   ||.    ||..|..: ||      :.:.::||...||..::.||  
Zfish  1153 ----ARYKC-CDVPITEGWGKYWWFLRKTCYLIVEHN------WFETLIIFMILLSSGALAFE-- 1204

  Fly  1246 NYRVMDHPTLQ-IAEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFL 1306
            :..:....|:| |.||.   |.....||:.||.:|.|..    .|..:....||.||..||...|
Zfish  1205 DVYIEQRKTIQIILEYADRVFTYIFILEMLLKWVAYGFV----KYFTNAWCWLDFFIVDVSIVSL 1265

  Fly  1307 CWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASY 1371
            ....|........:.|..||.:||||..:....||.||..|......|:.|..:.::...||:..
Zfish  1266 IANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM 1330

  Fly  1372 GVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWA 1427
            ||.|:.|:...|.:.|         ::.:.:|..:.               :.:|..:.    |.
Zfish  1331 GVNLFAGKYYYCFNQTAEEYFQVDVVNNKTECFALI---------------NANYTEVR----WK 1376

  Fly  1428 NPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG-------PVHA--VYIHIY----IFLG 1479
            |. :.||||:|...|.|.:|.:||||:   |::..||.       |::.  :|::||    |..|
Zfish  1377 NV-KINFDNVGAGYLALLQVATFKGWM---DIMYAAVDSRKVEDQPLYEDNIYMYIYFVIFIIFG 1437

  Fly  1480 CMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFT 1539
            ....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ..||:...
Zfish  1438 SFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKIQGMV 1501

  Fly  1540 YDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVV----EVVMKNIAFT 1600
            :|......|...|.:::.:|.:.:.:........||.::.   .:.|||:|    |.|:|..|..
Zfish  1502 FDFVTQQAFDISIMMLICLNMVTMMVETDDQSDETENILY---WINFVFIVAFTGEFVLKLFALR 1563

  Fly  1601 PRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTTLK 1658
             ..|:.:..|.:|.:|.:..::.:.|..::.   .||..   |.|:.|    |...:......::
Zfish  1564 -HYYFTNGWNVFDCVVVILSIVGMFLADLIE---KYFVSPTLFRVIRLARIGRILRLIKGAKGIR 1624

  Fly  1659 MLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVT 1723
            .|:..:.:|:...|.|...:||::|.:::.|...|..||...||....||.:....:..||.|.|
Zfish  1625 TLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKREIGIDDMYNFETFGNSMICLFMITT 1689

  Fly  1724 GEDWNKIMHDCMVQPPYC---------TLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVA 1779
            ...|:.::...:..||.|         |:..|     |||.:..:.:|..:.::...||:|:.:|
Zfish  1690 SAGWDGLLAPILNYPPDCDPNKENPGTTVKGN-----CGNPSVGIFFFVMYIIVSFLIVVNMYIA 1749

  Fly  1780 IIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDR 1844
            ||:||||:......|.|.. .|..:|...|...|......|...::......|:..|.. |:.: 
Zfish  1750 IILENFSVATEESADPLCE-DDFESFYEIWEKFDPDASQFITFAKLPDFADTLEHPLRV-PKPN- 1811

  Fly  1845 LLFKYMCYELDKLHNGEDVTFHDVINMLSYR------SVDIRKALQLEELL-----AREEFEYLV 1898
             :.:.:..:|..: :|:.:...|::...:.|      .:|:.:. |:||..     ::..:|.:.
Zfish  1812 -IIELIAMDLPMV-SGDRIHCLDILFAFTKRVLGDSGDLDMMRQ-QMEERFVAANPSKVSYEPIT 1873

  Fly  1899 ------EEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAV 1957
                  :|||:.:.|:       :..|:..||:   ..|...|..|.:.......||.|      
Zfish  1874 TTLRRKQEEVSAIVIQ-------RSYRSHLASR---GFICKRRPANNKLENGGGNQEKK------ 1922

  Fly  1958 DKSAISTISGAVAGACPPTSDAFSPTFSSTENEEKDG 1994
                    .|..:.|..|:.|:.:......:::..:|
Zfish  1923 --------EGTPSTASLPSYDSVTKPEKEKQDDNNEG 1951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 72/362 (20%)
Ion_trans 734..927 CDD:278921 60/221 (27%)
Ion_trans 1240..1497 CDD:278921 77/282 (27%)
Ion_trans 1571..1793 CDD:278921 60/241 (25%)
scn8abXP_005166128.1 Ion_trans 133..423 CDD:306908 63/312 (20%)
ARGLU <418..449 CDD:330370 2/30 (7%)
Na_trans_cytopl 503..672 CDD:314757 12/168 (7%)
Ion_trans 736..949 CDD:306908 57/230 (25%)
Na_trans_assoc 975..1178 CDD:310839 48/298 (16%)
Ion_trans 1183..1459 CDD:306908 84/310 (27%)
Na_channel_gate 1451..1503 CDD:240441 12/52 (23%)
Ion_trans 1508..1762 CDD:306908 63/265 (24%)
GPHH 1766..1829 CDD:318993 11/67 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.040

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