Protein Alignment na and cacna1fa

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_021334158.2
• Gene: cacna1fa / 793708
• ZFINID: ZDB-GENE-091204-7
• Length: 1985
• Species: Danio rerio
• Alignment Length: 2098
• Identity: 448/2098 - (21%)
• Similarity: 773/2098 - (36%)
• Gaps: 666/2098 - (31%)

  Fly   422 YLKDHWCQFDASMVSFLWISIILQIFEVL-------------EIVPKFSYLSIMRAPRPLIMIRF 473
            |::..|...|       :|.:|:.:|.|:             ....|...|.: :|.|...::|.
Zfish     6 YIRSGWNLLD-------FIIVIVGLFSVIAEMGGDGQKADSHHAAGKPGGLDV-KALRAFRVLRP 62

  Fly   474 LRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYD 535
            ||  |...:|..:|  |.|.| :...:.::.|..:|.:.:|.::|:: |.|.:...|....||
Zfish    63 LR--LVSGVPSLQIVLNSIMK-AMVPLLHIGLLVMFVIIIYAIIGLELFIGRMHKTCFYVGTE-- 122

  Fly   536 LYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCM--KMDFLSSYVIGFNG----FEDIATSIF 594
                       |.:.|     ||........|.||:  ..|....:. |.||    |::|..::.
Zfish   123 -----------LMVED-----DPTPCAFAGHGRVCIGNNTDCRGGWE-GPNGGITNFDNIFFAML 170

  Fly   595 TVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQF 655
            ||:|..:.|||..::|...||    || |   .||.:::.|.::.|.|:.:.|::..|::.|
Zfish   171 TVFQCITMEGWTDVLYWMNDSIGFELP-W---VYFVSLVIFGSFFVLNLVLGVLSGEFSKER--- 228

  Fly   656 QQMWGARGHIQKTAASQILSGNDTGWR--LVTIDD-----NKHGGLAP----------------- 696
             :....||.:||....|.:..:..|:.  |:..:|     ||...:|.
Zfish   229 -EKAVCRGELQKAQEKQQMEEDMIGYMDWLIEAEDMDEDGNKRAVVAKKKMMKKYGWYKHSEDGE 292

  Fly   697 ------------------------------------------ETCHAILRSPYFRMLVMSVILAN 719
                                                      :.|...::|..|..||:.::..|
Zfish   293 SDSDSEFEAFLDDDNGCCASIMARLMAISFCEQLYHLNVVMRKNCRVAVKSTNFYWLVLLLVFLN 357

  Fly   720 GIVTATMTFKHDGRPR---DVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLL 781
               ||....:|.|:|:   |: .||   ...:...|..||.|.|||..|::.|:....::|:..:
Zfish   358 ---TAASASEHYGQPKWLTDI-QER---ANKILLALFTLEMLMKIYSFGFQIYFMALFNRFDCFV 415

  Fly   782 AAG-------TTLHIVPMFYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIF 836
            ..|       ..:.::|   |.|::..:.:|::|:.|.:   ..|...|..:....|.:.||::.
Zfish   416 VCGGILETVLVEMEVIP---PIGISVLRCVRLLRIFKVTRHWAALSDLVGSLLNSMKAICSLLLL 477

  Fly   837 TMCLLIISSSISMQLF--CFLCDFTK-----FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKT 894
            ....|||.:.:.||||  .|..|.|:     |:|||.|.::.|||||.|.|..||.:.::.....
Zfish   478 LFLFLIIFALLGMQLFGGKFNFDETQMKRSTFDSFPSALLTCFQILTGEDWNSVMYDGIMAYGGP 542

  Fly   895 LTP--LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRI 957
            :.|  :|.:||::..:....|:|::|:|:.:|||..|...||.::.|..|:
Zfish   543 VFPNMIVCIYFVILFVCGNYILLNVFLAIAVDNLAGDGGKKKKEEKKEEEE-------------- 593

  Fly   958 FEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQK 1022
                                               |.|.||...|:......:.||.|
Zfish   594 -----------------------------------EWEDEDEREEDDAGNEMDDWEEN------- 616

  Fly  1023 PVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKP 1087
                           ..||.:.                              ||:..||     |
Zfish   617 ---------------EELRAIE------------------------------GLEGIGT-----P 631

  Fly  1088 WRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQA 1152
            .:|:                |.:.|:         .|...|..:|
Zfish   632 MKVE----------------SFQPKE---------KIVPIPDGSS-------------------- 651

  Fly  1153 EMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHN 1217
                                 .|::.:::..|..|..::|..|
Zfish   652 ---------------------FFVLGKKNCLRVACHNLIHHHY---------------------- 673

  Fly  1218 FLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADG 1278
                  :.::::|| ..||..|:..|.|   :..|..    |..|:|.|....::|:.||:...|
Zfish   674 ------FTNFILIF-IILSSFSLAAEDP---IKTHSVRNVMLGYADYVFTTVFTIEIMLKMTVYG 728

  Fly  1279 LFFTPKAYIKDVAAALDVFIYVVS-TSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRK 1342
            .|....::.::....||:.:..|| |||.    ||....|..::|.:||.:||||.......::.
Zfish   729 AFLHQGSFCRNAFNLLDLLVVSVSLTSFF----LNSSAISVVKILRVLRVLRPLRAINRAKGLKS 789

  Fly  1343 V---VYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFV 1404
            |   |:...|....||:|:|   ||.|:||..||||:.||..||.|......|:|.|.|:  ||
Zfish   790 VIQCVFVAIRTIGNILIVTT---LLQFMFACIGVQLFKGRFYRCTDEAKHTPEECKGTFV--VF- 848

  Fly  1405 TKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV----- 1464
                  ...|.::| |:..|||.| ..|||||:...||.||.|.:|:||   ..:|.||:
Zfish   849 ------KDGDMNHP-MVRERVWEN-SEFNFDNVLMGMLALFTVSTFEGW---PQLLYKAIDANAE 902

  Fly  1465 --GPVH------AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR---- 1517
              ||::      :::..|||.:.....:.:|||.||..:.| :|.|     :.:.|:|.|.
Zfish   903 NRGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIITFRE-QGEA-----EFKNCELNKNQRQC 961

  Fly  1518 ----LKIAQP--LHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTE 1575
                || |||  :::|..|...|.    :.|.....|:.::.|::|:|::.|::. :.:.::...
Zfish   962 VYYALK-AQPIKIYIPKNPSQLKF----WKIINSSQFEYIMFVLILLNTLTLAVQHYEQSKLFNS 1021

  Fly  1576 RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI----------- 1629
            .:.|::.:.|.:|.||:::|.:|..|..|:....|.:|.|:.|..::.|::..:
Zfish  1022 VMDILNMIFTTLFTVEMIIKLMALRPYHYFIDAWNSFDALIVVGSLVDIMIAELSGGGGHGEGKE 1086

  Fly  1630 ---LRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLT----------VGVSVCKSFFIIFGMFLL 1681
               .:..:::|..|.|  :|...:..|...::.|:.|          ||:.:...|||
Zfish  1087 GESAKVSITFFRLFRV--MRLVKLLSKGEGIRTLLWTFVKSLQALPYVGLLIAMIFFI------- 1142

  Fly  1682 VFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIM------HDCMVQP 1738
               |.:.|..:||.:...:.  :.|..||.:....|.:|||..|||.|.:||      |.|..:.
Zfish  1143 ---YGVIGMQIFGKIAIDDDTELNRNNNFQTFFMAVLLLFRCATGEQWQQIMLAALPGHRCDPES 1204

  Fly  1739 PYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIR 1803
            .: ..|.   |..||:..|.| ||.:|:.:..::::||.:|:||:||.  |...:..:|....:.
Zfish  1205 DF-EAGE---EFTCGSNLAYL-YFISFFALCAFLIINLFIAVIMDNFE--YLTRDWTVLGTHHLD 1262

  Fly  1804 NFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLH 1858
            .|:..|:..|....|       |..:||::..|   :|...|:.|    .||:...:     .|:
Zfish  1263 EFKRVWSDYDPEATGRIKHLDVVTMLRRIQPPLGFGKLCPHRVAC----RRLVAMNV-----PLY 1318

  Fly  1859 NGEDVTFHDVINMLSYRSVDIRK----ALQLEELLA------REEFEYLVEEEV----------A 1903
            ....|:|:..:..|...|:.|:.    ..|.|||.|      :.....|::|.:          .
Zfish  1319 PDGTVSFNATLFALVRTSLKIKTDGPIDQQNEELRAIIKKIWKRTKPKLLDEVIPPPSGNEVTAG 1383

  Fly  1904 KMTIRTWLEGCLKKIRAQNASKQQN-------SLIAGLRATNE-QPVMR--PNIQEDKAPLGAVD 1958
            |......::...||.|.:...:::.       ||.||||...: .|.||  ..:::::|..|.:.
Zfish  1384 KFYASFLIQDYFKKFRKRKEKERKKKGKDKSASLQAGLRTLQDLAPEMRLAMAMEDEEALEGEMM 1448

  Fly  1959 KSAISTISGAVAGACPPTSDAFSPTFS-------------STENEE-----KDGS---------- 1995
            :......|.:|....|||     ||.|             :|.|.|     ::||
Zfish  1449 EDEEFFRSDSVFSDVPPT-----PTMSTPRSTPMPPHLDQTTVNIELPPRIRNGSLMLEEALLDS 1508

  Fly  1996 --------SSAVVQLPHSETSIAGTGSSATGAAT------------ATGTSSGLGVGPPTVQ--- 2037
                    :..:|:.|:..:.:....:|:....|            |...|:|:.|.||:..
Zfish  1509 RPASALSENEVIVEQPNRLSPLPSKWTSSHSKLTPLWILNTNPRQGAQNDSTGVCVYPPSPSPDV 1573

  Fly  2038 -------------------STARHVMTVG-KRGYALNRSDSTGSSAGRKFL-------------- 2068
                               :|...||..| ..|.|.:.....||..|.:.:
Zfish  1574 AMQNGQVTEGDVVPGGHGGATMGGVMEAGVVHGVATDGVVHGGSIIGEEVVMGGGVTELTYTADQ 1638

  Fly  2069 -APTSSDPQ---------------------QRST--LSDKERLHITSQQRKKNSMTTLPHAGQLG 2109
             ...|.|||                     .|:|  ::..:.:::.....:.|    :..||...
Zfish  1639 GGVGSGDPQTAVLPEQQWFPEVPPTQAVVPDRTTECVAPVQPINLNGNGYQGN----IQDAGNYN 1699

  Fly  2110 QLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGE 2174
            ......|..|..|..:.             ||....::...:.:|| :|:|:...|..|:|
Zfish  1700 GSFPGNGYNGNGTNGTD-------------YPGNRCSSNGYSTNGY-NGNGYNSNGFNGNG---- 1746

  Fly  2175 HQMHHHHGGALGSPSAMM 2192
            :..:.:.|....:...|:
Zfish  1747 YNNNEYSGNGFAARRRML 1764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	62/257 (24%)
		Ion_trans	705..927	CDD:459842	69/243 (28%)
		Ion_trans	1224..1497	CDD:459842	94/293 (32%)
		Ion_trans	1545..1793	CDD:459842	67/280 (24%)
cacna1fa	XP_021334158.2	Ion_trans	<5..231	CDD:459842	62/262 (24%)
		Ion_trans	343..577	CDD:459842	69/243 (28%)
		Ion_trans	671..908	CDD:459842	87/289 (30%)
		Ion_trans	993..1253	CDD:459842	67/278 (24%)
		GPHH	1263..1316	CDD:465306	13/61 (21%)
		Ca_chan_IQ	1326..1394	CDD:462591	11/67 (16%)
		CAC1F_C	<1759..1984	CDD:465298	1/6 (17%)