DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1fa

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021334158.1 Gene:cacna1fa / 793708 ZFINID:ZDB-GENE-091204-7 Length:2115 Species:Danio rerio


Alignment Length:2279 Identity:481/2279 - (21%)
Similarity:828/2279 - (36%) Gaps:728/2279 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   251 NGAGLGP-----VVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICG-GISSTVGSAAITGV--PP 307
            :|.||.|     :...|..|....||..........|..|...:|. .:|:.:..||:..|  .|
Zfish     7 DGVGLDPSKTDTLNSTGSAGQKRAGGAKKHTQANKSALRAPRALCCLTLSNPIRMAALALVEWKP 71

  Fly   308 IGLGIATGI-GNKIMLGRKQSLKGGEPFLADYGPEESLN-ESADIEWVNKLWVRRLMRLCALVSL 370
            ..:.|...| .|.:.||      ..:||     ||:..| .:.::|.|..:::            
Zfish    72 FDIFILLAIFANCVALG------VSKPF-----PEDDSNATNHNLEQVEYVFL------------ 113

  Fly   371 TSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMV 435
                                         ::||.|...|:...|::.....|::..|...|    
Zfish   114 -----------------------------VIFTIETFTKILAYGLVMHPSAYIRSGWNLLD---- 145

  Fly   436 SFLWISIILQIFEVL-------------EIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI 487
               :|.:|:.:|.|:             ....|...|.: :|.|...::|.||  |...:|..:|
Zfish   146 ---FIIVIVGLFSVIAEMGGDGQKADSHHAAGKPGGLDV-KALRAFRVLRPLR--LVSGVPSLQI 204

  Fly   488 --NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAI 549
              |.|.| :...:.::.|..:|.:.:|.::|:: |.|.:...|....||             |.:
Zfish   205 VLNSIMK-AMVPLLHIGLLVMFVIIIYAIIGLELFIGRMHKTCFYVGTE-------------LMV 255

  Fly   550 PDTFCSMDPDSGYQCSPGMVCM--KMDFLSSYVIGFNG----FEDIATSIFTVYQAASQEGWVFI 608
            .|     ||........|.||:  ..|....:. |.||    |::|..::.||:|..:.|||..:
Zfish   256 ED-----DPTPCAFAGHGRVCIGNNTDCRGGWE-GPNGGITNFDNIFFAMLTVFQCITMEGWTDV 314

  Fly   609 MYRAIDS----LPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTA 669
            :|...||    || |   .||.:::.|.::.|.|:.:.|::..|::.|    :....||.:||..
Zfish   315 LYWMNDSIGFELP-W---VYFVSLVIFGSFFVLNLVLGVLSGEFSKER----EKAVCRGELQKAQ 371

  Fly   670 ASQILSGNDTGWR--LVTIDD-----NKHGGLAP------------------------------- 696
            ..|.:..:..|:.  |:..:|     ||...:|.                               
Zfish   372 EKQQMEEDMIGYMDWLIEAEDMDEDGNKRAVVAKKKMMKKYGWYKHSEDGESDSDSEFEAFLDDD 436

  Fly   697 ----------------------------ETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGR 733
                                        :.|...::|..|..||:.::..|   ||....:|.|:
Zfish   437 NGCCASIMARLMAISFCEQLYHLNVVMRKNCRVAVKSTNFYWLVLLLVFLN---TAASASEHYGQ 498

  Fly   734 PR---DVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG-------TTLH 788
            |:   |: .||   ...:...|..||.|.|||..|::.|:....::|:..:..|       ..:.
Zfish   499 PKWLTDI-QER---ANKILLALFTLEMLMKIYSFGFQIYFMALFNRFDCFVVCGGILETVLVEME 559

  Fly   789 IVPMFYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQ 850
            ::|   |.|::..:.:|::|:.|.:   ..|...|..:....|.:.||::.....|||.:.:.||
Zfish   560 VIP---PIGISVLRCVRLLRIFKVTRHWAALSDLVGSLLNSMKAICSLLLLLFLFLIIFALLGMQ 621

  Fly   851 LF--CFLCDFTK-----FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVYFILY 906
            ||  .|..|.|:     |:|||.|.::.|||||.|.|..||.:.::.....:.|  :|.:||::.
Zfish   622 LFGGKFNFDETQMKRSTFDSFPSALLTCFQILTGEDWNSVMYDGIMAYGGPVFPNMIVCIYFVIL 686

  Fly   907 HLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILH 971
            .:....|:|::|:|:.:|||..|...||.::.|..|:                            
Zfish   687 FVCGNYILLNVFLAIAVDNLAGDGGKKKKEEKKEEEE---------------------------- 723

  Fly   972 RIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036
                                 |.|.||...|:......:.||.|                     
Zfish   724 ---------------------EWEDEDEREEDDAGNEMDDWEEN--------------------- 746

  Fly  1037 GSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIR 1101
             ..||.:.                              ||:..||     |.:|:          
Zfish   747 -EELRAIE------------------------------GLEGIGT-----PMKVE---------- 765

  Fly  1102 RSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLREN 1166
                  |.:.|:         .|...|..:|                                  
Zfish   766 ------SFQPKE---------KIVPIPDGSS---------------------------------- 781

  Fly  1167 HPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIF 1231
                   .|::.:::..|..|..::|..|                            :.::::||
Zfish   782 -------FFVLGKKNCLRVACHNLIHHHY----------------------------FTNFILIF 811

  Fly  1232 ATTLSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAA 1292
             ..||..|:..|.|   :..|..    |..|:|.|....::|:.||:...|.|....::.::...
Zfish   812 -IILSSFSLAAEDP---IKTHSVRNVMLGYADYVFTTVFTIEIMLKMTVYGAFLHQGSFCRNAFN 872

  Fly  1293 ALDVFIYVVS-TSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKV---VYELCRGFKE 1353
            .||:.:..|| |||.    ||....|..::|.:||.:||||.......::.|   |:...|....
Zfish   873 LLDLLVVSVSLTSFF----LNSSAISVVKILRVLRVLRPLRAINRAKGLKSVIQCVFVAIRTIGN 933

  Fly  1354 ILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYP 1418
            ||:|:|   ||.|:||..||||:.||..||.|......|:|.|.|:  ||       ...|.::|
Zfish   934 ILIVTT---LLQFMFACIGVQLFKGRFYRCTDEAKHTPEECKGTFV--VF-------KDGDMNHP 986

  Fly  1419 AMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AV 1470
             |:..|||.| ..|||||:...||.||.|.:|:||   ..:|.||:       ||::      ::
Zfish   987 -MVRERVWEN-SEFNFDNVLMGMLALFTVSTFEGW---PQLLYKAIDANAENRGPIYNYRVEISI 1046

  Fly  1471 YIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQP--LH 1525
            :..|||.:.....:.:|||.||..:.| :|.|     :.:.|:|.|.        || |||  ::
Zfish  1047 FFIIYIIIIAFFMMNIFVGFVIITFRE-QGEA-----EFKNCELNKNQRQCVYYALK-AQPIKIY 1104

  Fly  1526 LPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFV 1589
            :|..|...|.    :.|.....|:.::.|::|:|::.|::. :.:.::....:.|::.:.|.:|.
Zfish  1105 IPKNPSQLKF----WKIINSSQFEYIMFVLILLNTLTLAVQHYEQSKLFNSVMDILNMIFTTLFT 1165

  Fly  1590 VEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI--------------LRNDLSYFFGF 1640
            ||:::|.:|..|..|:....|.:|.|:.|..::.|::..:              .:..:::|..|
Zfish  1166 VEMIIKLMALRPYHYFIDAWNSFDALIVVGSLVDIMIAELSGGGGHGEGKEGESAKVSITFFRLF 1230

  Fly  1641 MVVILRFFTITGKHTTLKMLMLT----------VGVSVCKSFFIIFGMFLLVFFYALAGTILFGT 1695
            .|  :|...:..|...::.|:.|          ||:.:...|||          |.:.|..:||.
Zfish  1231 RV--MRLVKLLSKGEGIRTLLWTFVKSLQALPYVGLLIAMIFFI----------YGVIGMQIFGK 1283

  Fly  1696 VKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIM------HDCMVQPPYCTLGNNYWETDC 1752
            :...:.  :.|..||.:....|.:|||..|||.|.:||      |.|..:..: ..|.   |..|
Zfish  1284 IAIDDDTELNRNNNFQTFFMAVLLLFRCATGEQWQQIMLAALPGHRCDPESDF-EAGE---EFTC 1344

  Fly  1753 GNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQR 1817
            |:..|.| ||.:|:.:..::::||.:|:||:||.  |...:..:|....:..|:..|:..|....
Zfish  1345 GSNLAYL-YFISFFALCAFLIINLFIAVIMDNFE--YLTRDWTVLGTHHLDEFKRVWSDYDPEAT 1406

  Fly  1818 G-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINML 1872
            |       |..:||::..|   :|...|:.|    .||:...:     .|:....|:|:..:..|
Zfish  1407 GRIKHLDVVTMLRRIQPPLGFGKLCPHRVAC----RRLVAMNV-----PLYPDGTVSFNATLFAL 1462

  Fly  1873 SYRSVDIRK----ALQLEELLA------REEFEYLVEEEV----------AKMTIRTWLEGCLKK 1917
            ...|:.|:.    ..|.|||.|      :.....|::|.:          .|......::...||
Zfish  1463 VRTSLKIKTDGPIDQQNEELRAIIKKIWKRTKPKLLDEVIPPPSGNEVTAGKFYASFLIQDYFKK 1527

  Fly  1918 IRAQNASKQQN-------SLIAGLRATNE-QPVMR--PNIQEDKAPLGAVDKSAISTISGAVAGA 1972
            .|.:...:::.       ||.||||...: .|.||  ..:::::|..|.:.:......|.:|...
Zfish  1528 FRKRKEKERKKKGKDKSASLQAGLRTLQDLAPEMRLAMAMEDEEALEGEMMEDEEFFRSDSVFSD 1592

  Fly  1973 CPPTSDAFSPTFS-------------STENEE-----KDGS------------------SSAVVQ 2001
            .|||     ||.|             :|.|.|     ::||                  :..:|:
Zfish  1593 VPPT-----PTMSTPRSTPMPPHLDQTTVNIELPPRIRNGSLMLEEALLDSRPASALSENEVIVE 1652

  Fly  2002 LPHSETSIAGTGSSATGAAT------------ATGTSSGLGVGPPTVQ----------------- 2037
            .|:..:.:....:|:....|            |...|:|:.|.||:..                 
Zfish  1653 QPNRLSPLPSKWTSSHSKLTPLWILNTNPRQGAQNDSTGVCVYPPSPSPDVAMQNGQVTEGDVVP 1717

  Fly  2038 -----STARHVMTVG-KRGYALNRSDSTGSSAGRKFL---------------APTSSDPQ----- 2076
                 :|...||..| ..|.|.:.....||..|.:.:               ...|.|||     
Zfish  1718 GGHGGATMGGVMEAGVVHGVATDGVVHGGSIIGEEVVMGGGVTELTYTADQGGVGSGDPQTAVLP 1782

  Fly  2077 ----------------QRST--LSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATK 2123
                            .|:|  ::..:.:::.....:.|    :..||.........|..|..|.
Zfish  1783 EQQWFPEVPPTQAVVPDRTTECVAPVQPINLNGNGYQGN----IQDAGNYNGSFPGNGYNGNGTN 1843

  Fly  2124 SSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGHGHGHGHGGHGGHGGHGEHQMHHHHGGALGSP 2188
            .:.             ||....::...:.:|| :|:|:...|..|:|    :..:.:.|....:.
Zfish  1844 GTD-------------YPGNRCSSNGYSTNGY-NGNGYNSNGFNGNG----YNNNEYSGNGFAAR 1890

  Fly  2189 SAMM 2192
            ..|:
Zfish  1891 RRML 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 67/306 (22%)
Ion_trans 734..927 CDD:278921 60/214 (28%)
Ion_trans 1240..1497 CDD:278921 89/277 (32%)
Ion_trans 1571..1793 CDD:278921 62/253 (25%)
cacna1faXP_021334158.1 Ion_trans 69..361 CDD:306908 80/381 (21%)
Ion_trans 473..707 CDD:306908 69/243 (28%)
Ion_trans 801..1038 CDD:306908 87/289 (30%)
Ion_trans 1123..1383 CDD:306908 67/278 (24%)
GPHH 1385..1455 CDD:318993 16/78 (21%)
Ca_chan_IQ 1457..1524 CDD:312334 11/66 (17%)
CAC1F_C 1550..2114 CDD:318975 63/372 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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