DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and CACNA1S

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens


Alignment Length:1986 Identity:430/1986 - (21%)
Similarity:771/1986 - (38%) Gaps:532/1986 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRA 464
            ::|:.|...|:...|.|..:..||:..|...|.::|.....::||:...|::     |:.:.|.:
Human    95 IVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQ-----SHTAPMSS 154

  Fly   465 PRPLIMIRFLRVF-------LKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF 520
            ....:.::.||.|       |...:|..::  |.||| :...::::.|..||.:.:|.::|::.|
Human   155 KGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFK-AMLPLFHIALLVLFMVIIYAIIGLELF 218

  Fly   521 -GELKNHCVMNNTEYDLYKRPILTI-NSLAIPDTFCSMDPDSGYQCS-PGMVCMKMDFLSSYVIG 582
             |::...|....|:.      :.|: |....|   |:. ..||.:|: .|..|..         |
Human   219 KGKMHKTCYFIGTDI------VATVENEEPSP---CAR-TGSGRRCTINGSECRG---------G 264

  Fly   583 FNG-------FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVF 640
            :.|       |::...|:.||||..:.|||..::|...|::.......||.|:|...::.:.|:.
Human   265 WPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLV 329

  Fly   641 IAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGW-------RLVTIDDNKHGGLAPE- 697
            :.|::..|.:.|.:.:    :||..||....|.|..:..|:       .::.::|.:.|.|:.: 
Human   330 LGVLSGEFTKEREKAK----SRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDE 390

  Fly   698 ---------------------------------TCHAILRSPYFRMLVMSVILANGIVTATMTFK 729
                                             .||.|::|..|..||:.::..|   |.::..:
Human   391 GGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALN---TLSIASE 452

  Fly   730 HDGRP------RDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLH 788
            |..:|      :|:       ...|...|...|.|.|:|.||.|.|:....::|:..:.....|.
Human   453 HHNQPLWLTRLQDI-------ANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILE 510

  Fly   789 IVPM----FYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSS 846
            |:.:    ..|.|::..:.:|::|:.|.:   ..|...|..:....:.:.||::.....::|.:.
Human   511 ILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFAL 575

  Fly   847 ISMQLFCFLCDF-------TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVY 902
            :.||||....||       :.|::||:|.:|:||:||.|.|..:|...::.......|  ||.:|
Human   576 LGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640

  Fly   903 FILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQM 967
            ||:..:....|:|::|:|:.:|||...|.:...::.|..|:.         |.::.:..||..: 
Human   641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKK---------RRKMSKGLPDKSE- 695

  Fly   968 TILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAK 1032
                                       |.:.::.:..               :|||         
Human   696 ---------------------------EEKSTMAKKL---------------EQKP--------- 709

  Fly  1033 VRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGS 1097
                                                        |.:|..|.:| .::|:     
Human   710 --------------------------------------------KGEGIPTTAK-LKIDE----- 724

  Fly  1098 RSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRAN-SGRARPHDLDIKLLQAKRQQAEMRRNQREE 1161
                  ..|...::|..|            |.|: .|.....:.:|.|....|..||::..::..
Human   725 ------FESNVNEVKDPY------------PSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAV 771

  Fly  1162 DLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLD 1226
            .:.|...|     |:....::.|.:|.:||:|.:                            :.:
Human   772 PIPEASSF-----FIFSPTNKIRVLCHRIVNATW----------------------------FTN 803

  Fly  1227 WVMIFATTLSCISMMFETP-NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDV 1290
            ::::| ..||..::..|.| ....|.:..|:..:.||....::|:.||:...|.|....::.::.
Human   804 FILLF-ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNY 867

  Fly  1291 AAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVV---YELCRGFK 1352
            ...||:.:..||   |..|.|.....|..::|.:||.:||||.......::.||   :.......
Human   868 FNMLDLLVVAVS---LISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIG 929

  Fly  1353 EILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESY 1417
            .|:||:|   ||.|:||..||||:.|:..||.|.:....|:|.|.:    :|.|      ..:..
Human   930 NIVLVTT---LLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYY----YVYK------DGDPM 981

  Fly  1418 PAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKA-------VGPVH------A 1469
            ...|..|.|.: ..|:|||:..||::||.|.:|:||   ..:|.||       |||::      |
Human   982 QIELRHREWVH-SDFHFDNVLSAMMSLFTVSTFEGW---PQLLYKAIDSNAEDVGPIYNNRVEMA 1042

  Fly  1470 VYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL-- 1524
            ::..|||.|.....:.:|||.||..:.|...|      :.:.|:|.|.        || |:||  
Human  1043 IFFIIYIILIAFFMMNIFVGFVIVTFQEQGET------EYKNCELDKNQRQCVQYALK-ARPLRC 1100

  Fly  1525 HLPPRPDGRKIRAFTYDITQHII----FKRVIAVVVLINSMLLSITWIKGEVH---TERLVIVSA 1582
            ::|..|       :.|.: .:|:    |:.::..::::|::.|      |..|   :|::..:|.
Human  1101 YIPKNP-------YQYQV-WYIVTSSYFEYLMFALIMLNTICL------GMQHYNQSEQMNHISD 1151

  Fly  1583 VL----TFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI-------------- 1629
            :|    |.:|.:|:::|.:||..|||:....|.:|.|:.:..:|.:||..|              
Human  1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLG 1216

  Fly  1630 -----------LRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGV-----SVCKSF----FI 1674
                       .|...::|..|.|:.|           :|:|....||     :..|||    ::
Human  1217 GGCGNVDPDESARISSAFFRLFRVMRL-----------IKLLSRAEGVRTLLWTFIKSFQALPYV 1270

  Fly  1675 IFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ 1737
            ...:.:|.|.||:.|..:||.:...:|  |.|..||.:....|.:|||..|||.|.:|:..|. .
Human  1271 ALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS-Y 1334

  Fly  1738 PPYCTLGNNY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLS 1798
            ...|...::|   .|..|| ||  :..||.:||::..::|:||.||:||:||.  |...:.::|.
Human  1335 GKLCDPESDYAPGEEYTCGTNF--AYYYFISFYMLCAFLVINLFVAVIMDNFD--YLTRDWSILG 1395

  Fly  1799 YADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLK----------GRLECDPQKDRLLFKYMCYE 1853
            ...:..|:..|...|...:|.|....|..:||.::          .|:.|    .||:...|   
Human  1396 PHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVAC----KRLVGMNM--- 1453

  Fly  1854 LDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLV-------------------- 1898
              .|::...|||:..:..|...::.|:.....|:  |.||...::                    
Human  1454 --PLNSDGTVTFNATLFALVRTALKIKTEGNFEQ--ANEELRAIIKKIWKRTSMKLLDQVIPPIG 1514

  Fly  1899 EEEV------AKMTIRTWLEGCLKKIRAQNASKQQNSLI---AGLRATNEQPVMRPNI------- 1947
            ::||      |...|:......:|:.......:.:..::   ||||...|:..  |.|       
Human  1515 DDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLRTIEEEAA--PEICRTVSGD 1577

  Fly  1948 -----QEDKAPLGAVDKSAISTISGAVAG----------ACPPTSDAFSP-TFSSTENEEKDGSS 1996
                 :.::|.:.|..:..|...:|.:.|          :.||......| .|:..|.||.: |.
Human  1578 LAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEME-SP 1641

  Fly  1997 SAVVQLPHSETS--IAGTGSSATGAATATGTSSGLGVG-----------PPTVQSTARHVMTVGK 2048
            ..:...|....:  :|...::...|..|.|.|:.....           |...::.|.....:|:
Human  1642 VFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQ 1706

  Fly  2049 ----------------RGYALNRSDSTGSSAGRKFLAP--TSSDPQQRSTLS----DKERLHITS 2091
                            :|....|:...|.:.......|  .||.|:.|.:.:    .:|..|..|
Human  1707 PCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRS 1771

  Fly  2092 QQRKKNSMTTLPHAGQLGQLAKQRGGGGEATKSSSF 2127
             .|:..|..:.|....|.|.|..|||.|.....::|
Human  1772 -TRENTSRCSAPATALLIQKALVRGGLGTLAADANF 1806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 63/272 (23%)
Ion_trans 734..927 CDD:278921 55/214 (26%)
Ion_trans 1240..1497 CDD:278921 81/273 (30%)
Ion_trans 1571..1793 CDD:278921 75/268 (28%)
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 61/266 (23%)
Ion_trans 68..345 CDD:278921 63/274 (23%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 3/16 (19%)
II. /evidence=ECO:0000305 418..664 64/255 (25%)
Ion_trans 449..672 CDD:278921 58/229 (25%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Rib_recp_KP_reg 671..>777 CDD:282899 26/234 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 11/146 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 7/37 (19%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 2/12 (17%)
III. /evidence=ECO:0000305 786..1068 89/330 (27%)
Ion_trans 816..1075 CDD:278921 83/284 (29%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 32/98 (33%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 1/2 (50%)
IV. /evidence=ECO:0000305 1105..1384 79/306 (26%)
Ion_trans 1135..1392 CDD:278921 77/278 (28%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 22/69 (32%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 19/45 (42%)
GPHH 1400..1463 CDD:293510 15/71 (21%)
Ca_chan_IQ 1465..1536 CDD:285917 10/72 (14%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 3/19 (16%)
CAC1F_C <1692..1833 CDD:293490 24/116 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 11/49 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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