DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and CACNA1F

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_005174.2 Gene:CACNA1F / 778 HGNCID:1393 Length:1977 Species:Homo sapiens


Alignment Length:2279 Identity:496/2279 - (21%)
Similarity:821/2279 - (36%) Gaps:731/2279 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 GGSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGS 299
            ||...|..||..    ||||.||..|       |..|...:.|...||:..|........|...:
Human     6 GGKDTTPEPSPA----NGAGPGPEWG-------LCPGPPAVEGESSGASGLGTPKRRNQHSKHKT 59

  Fly   300 AAITGV--PPIGLGIATGIGNKIMLGRKQ--SLKGGEPFLADYGPEESLNESADIEWVNKLWVRR 360
            .|:...  .|..|...| :.|.:   |:.  |:...:||              ||          
Human    60 VAVASAQRSPRALFCLT-LANPL---RRSCISIVEWKPF--------------DI---------- 96

  Fly   361 LMRLCALVSLT----SVSLNTPKTFERYPSLQFITFASDTAVT-------------LLFTAEMIA 408
                  |:.||    .|:|..           :|.|..|.:.|             ::||.|.:.
Human    97 ------LILLTIFANCVALGV-----------YIPFPEDDSNTANHNLEQVEYVFLVIFTVETVL 144

  Fly   409 KMHIRG-VLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV-LEIVP----------------K 455
            |:...| |||... |:::.|...|       :|.:::.:|.| ||..|                .
Human   145 KIVAYGLVLHPSA-YIRNGWNLLD-------FIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFD 201

  Fly   456 FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ 518
            ...|...|..|||.::.        .:|...|  |.|.| :...:.::.|..||.:.:|.::|::
Human   202 VKALRAFRVLRPLRLVS--------GVPSLHIVLNSIMK-ALVPLLHIALLVLFVIIIYAIIGLE 257

  Fly   519 -FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCS----------PGMVCMK 572
             |.|.:...|....::.:..:.|....:|            .||..|:          ||...  
Human   258 LFLGRMHKTCYFLGSDMEAEEDPSPCASS------------GSGRACTLNQTECRGRWPGPNG-- 308

  Fly   573 MDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMIFFLA 633
                     |...|::...::.||:|..:.|||..::|...|:    || |   .||.:::.|.:
Human   309 ---------GITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELP-W---VYFVSLVIFGS 360

  Fly   634 WLVKNVFIAVITETFNEIRV------------QFQQM---------W------------------ 659
            :.|.|:.:.|::..|::.|.            :.|||         |                  
Human   361 FFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNL 425

  Fly   660 ------GARGH------------------------IQKTAASQILSGNDTGWRLVT--IDDNKHG 692
                  |..||                        ...|::...|..:|||....|  .:|.:.|
Human   426 GSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEG 490

  Fly   693 GLAPET-------------------------CHAILRSPYFRMLVMSVILANGIVTATMTFKHDG 732
            .||..|                         |...::|......|:.::..|   |.|:..:|.|
Human   491 ALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLN---TLTIASEHHG 552

  Fly   733 RPRDVFYERYY-YIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIVPM 792
            :|  |:..:.. |...|..||..:|.|.|:|.||...|.....::|:..:..|    |||..|..
Human   553 QP--VWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGA 615

  Fly   793 FYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCF 854
            ..|.|::..:.:|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.:.||||..
Human   616 MQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 680

  Fly   855 LCDF----TK---FESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAVYFILYHLFV 910
            ..:|    ||   |::||:|.:::|||||.|.|..||.:.::.......|  ||.:|||:..:..
Human   681 KFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICG 745

  Fly   911 TLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPN 975
            ..|:|::|:|:.:||| ...|....|. |..|:|.|               .|.||       .|
Human   746 NYILLNVFLAIAVDNL-ASGDAGTAKD-KGGEKSNE---------------KDLPQ-------EN 786

  Fly   976 DFMLP---KVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAG 1037
            :.::|   |..|...:....::|.|:...|..:....|                           
Human   787 EGLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEE--------------------------- 824

  Fly  1038 SSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRR 1102
                                             :|.||                           
Human   825 ---------------------------------EGAGG--------------------------- 829

  Fly  1103 SVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENH 1167
                                                   ::|||      |:...::...:.|..
Human   830 ---------------------------------------VELLQ------EVVPKEKVVPIPEGS 849

  Fly  1168 PFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFA 1232
            .|     |.:.:.:..||.|..::|.                      |.|..|      :::| 
Human   850 AF-----FCLSQTNPLRKGCHTLIHH----------------------HVFTNL------ILVF- 880

  Fly  1233 TTLSCISMMFETP----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAA 1293
            ..||.:|:..|.|    ::|  :| .|...:|.|....::|:.||:...|.|....::.:.....
Human   881 IILSSVSLAAEDPIRAHSFR--NH-ILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNM 942

  Fly  1294 LDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEIL 1355
            ||  :.|||.|.:.: .::....|..::|.:||.:||||....   :.|:.:.|:...|....|:
Human   943 LD--LLVVSVSLISF-GIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIM 1004

  Fly  1356 LVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAM 1420
            :|:|   ||.|:||..||||:.|:...|.|......::|.|.|:         :.|..|.|.| :
Human  1005 IVTT---LLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFL---------VYPDGDVSRP-L 1056

  Fly  1421 LVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AVYI 1472
            :..|:|.| ..|||||:..||:.||.|.:|:||   ..:|.||:       ||::      :|:.
Human  1057 VRERLWVN-SDFNFDNVLSAMMALFTVSTFEGW---PALLYKAIDAYAEDHGPIYNYRVEISVFF 1117

  Fly  1473 HIYIFLGCMIGLTLFVGVVIANY----SENKGTALLTVDQRRWCDLKKRLKIAQPL--HLPPRPD 1531
            .:||.:.....:.:|||.||..:    .:......|..:||: | ::..|| ||||  ::|..|.
Human  1118 IVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQ-C-VEYALK-AQPLRRYIPKNPH 1179

  Fly  1532 GRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTER-------LVIVSAVLTFVFV 1589
            ..::.|    ......|:.::.:::|:|::.|::.      |.|:       :.|::.|.|.:|.
Human  1180 QYRVWA----TVNSAAFEYLMFLLILLNTVALAMQ------HYEQTAPFNYAMDILNMVFTGLFT 1234

  Fly  1590 VEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTI-------------LRNDLSYFFGFM 1641
            :|:|:|.|||.|:.|:....|.:|.|:.|..::.|.:..:             .|..:::|..|.
Human  1235 IEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFR 1299

  Fly  1642 VVILRFFTITGKHTTLKMLMLTVGVSVCKSF----FIIFGMFLLVFFYALAGTILFGTVKYGEG- 1701
            |  :|...:..|...::.|:.|    ..|||    ::...:.::.|.||:.|..:||.|...:| 
Human  1300 V--MRLVKLLSKGEGIRTLLWT----FIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGT 1358

  Fly  1702 -IGRRANFGSPVTGVAMLFRIVTGEDWNKIM------HDCMVQPPYCTLGNNYWETDCG-NFTAS 1758
             |.|..||.:....|.:|||..|||.|.:||      :.|   .|....|... |..|| ||  :
Human  1359 QINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRC---DPESDFGPGE-EFTCGSNF--A 1417

  Fly  1759 LIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRG----- 1818
            :.||.:|:::..::::||.||:||:||.  |...:.::|....:..|:..|:..|...:|     
Human  1418 IAYFISFFMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHL 1480

  Fly  1819 --VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVD 1878
              |..:||::..|   :|...|:.|    .||:...|     .|::...|||:..:..|...|:.
Human  1481 DVVALLRRIQPPLGFGKLCPHRVAC----KRLVAMNM-----PLNSDGTVTFNATLFALVRTSLK 1536

  Fly  1879 IRKALQLEELLAREEFEYLV--------------------EEE--VAKMTIRTWLEGCLKKIRAQ 1921
            |:....||:  |.:|...::                    |||  |.|......::...:|.|.:
Human  1537 IKTEGNLEQ--ANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRR 1599

  Fly  1922 N---------ASKQQNSLIAGLRATNE-QPVMRPNI----------------QEDKAPLGAVDKS 1960
            .         |....::|.||||:..: .|.||..:                :||:..|.....:
Human  1600 KEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTEEEEEEGQEGVEEEDEKDLETNKAT 1664

  Fly  1961 AISTIS---GAVAGACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSS----ATG 2018
            .:|..|   |:......|..|....:.|...:::..|:.::      |:.|:...||:    .:|
Human  1665 MVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTS------SQPSVPQAGSNTHRRGSG 1723

  Fly  2019 AATAT----GTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAG--------------- 2064
            |...|    |.|...|......|.....|.         :|.......||               
Human  1724 ALIFTIPEEGNSQPKGTKGQNKQDEDEEVP---------DRLSYLDEQAGTPPCSVLLPPHRAQR 1779

  Fly  2065 ---------RKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLP-----HAGQLGQLAKQR 2115
                     |:.|.||.:..:...|:...:|         :.|...||     |.|:  .....|
Human  1780 YMDGHLVPRRRLLPPTPAGRKPSFTIQCLQR---------QGSCEDLPIPGTYHRGR--NSGPNR 1833

  Fly  2116 GGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGY-GHGHG--------HGHGGHG--GH 2169
            ..|..||.         .:.|:..|..:......||..|| |...|        |..|.|.  .|
Human  1834 AQGSWATP---------PQRGRLLYAPLLLVEEGAAGEGYLGRSSGPLRTFTCLHVPGTHSDPSH 1889

  Fly  2170 GGHG 2173
            |..|
Human  1890 GKRG 1893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 69/340 (20%)
Ion_trans 734..927 CDD:278921 64/209 (31%)
Ion_trans 1240..1497 CDD:278921 80/280 (29%)
Ion_trans 1571..1793 CDD:278921 72/254 (28%)
CACNA1FNP_005174.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 19/64 (30%)
I 79..375 77/383 (20%)
Ion_trans 109..383 CDD:278921 68/328 (21%)
Binding to the beta subunit. /evidence=ECO:0000250 395..412 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..441 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..488 7/32 (22%)
II 515..761 71/250 (28%)
Ion_trans 546..763 CDD:278921 67/219 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..830 19/211 (9%)
III 858..1140 91/333 (27%)
Ion_trans 888..1107 CDD:278921 72/241 (30%)
Dihydropyridine binding. /evidence=ECO:0000250 1060..1150 29/93 (31%)
IV 1177..1444 75/288 (26%)
Ion_trans 1207..1452 CDD:278921 73/264 (28%)
Dihydropyridine binding. /evidence=ECO:0000250 1397..1463 21/73 (29%)
Phenylalkylamine binding. /evidence=ECO:0000250 1409..1452 17/46 (37%)
GPHH 1460..1523 CDD:293510 16/71 (23%)
Ca_chan_IQ 1525..1596 CDD:285917 12/72 (17%)
CAC1F_C 1620..1974 CDD:293490 60/309 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1637..1754 22/131 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1816..1841 7/26 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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