Protein Alignment na and CACNA1E

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_016857732.1
• Gene: CACNA1E / 777
• HGNCID: 1392
• Length: 2458
• Species: Homo sapiens
• Alignment Length: 2241
• Identity: 470/2241 - (20%)
• Similarity: 804/2241 - (35%)
• Gaps: 651/2241 - (29%)

  Fly   312 IATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLN 376
            :||.|.|.|:|..:|.|           ||:                          ..|.:|..
Human   241 LATIIANCIVLALEQHL-----------PED--------------------------DKTPMSRR 268

  Fly   377 TPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWIS 441
            ..|| |.|    ||.         :|..|...|:...|.:..:..||::.|...|..:|    :|
Human   269 LEKT-EPY----FIG---------IFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV----LS 315

  Fly   442 IIL-------------------QIFEVLEIVPKFSYL-----SIMRAPRPLIMIRFLRVFLKFSM 482
            .||                   ::...|::|.....|     |||:|..||:.|..|
Human   316 GILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLL-------- 372

  Fly   483 PKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINS 546
                                |||...|  :.::|::|: |:|...|.|||:
Human   373 --------------------LFFAILM--FAIIGLEFYSGKLHRACFMNNS-------------- 401

  Fly   547 LAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYR 611
             .|.:.|....|.....|..|..|  .|::... .|...|::|..::.||:|..:.|||..::|.
Human   402 -GILEGFDPPHPCGVQGCPAGYEC--KDWIGPN-DGITQFDNILFAVLTVFQCITMEGWTTVLYN 462

  Fly   612 AIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSG 676
            ..|:|.|.....||..:|...::.|.|:.:.|::..|.:.|.:.:.    |....|....|.:..
Human   463 TNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN----RRAFMKLRRQQQIER 523

  Fly   677 NDTGWR--------LVTIDDNKHGGL-----------------------APETC----------- 699
            ...|:|        ::..::||:.|.                       :.|.|
Human   524 ELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLA 588

  Fly   700 --------------------------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVF 738
                                      ..:::|..|..:|:|::..|   ||.:...|..:|:.:.
Human   589 RASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALN---TACVAIVHHNQPQWLT 650

  Fly   739 YERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLT 799
            : ..||.|.:|..|..||...|:|.:|.|.|:..|.:.|:..:..|:...:| .:|.|.   |::
Human   651 H-LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGIS 714

  Fly   800 YFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF--- 858
            ..:.||::|:.|.:   ..|...|..:....|.:.||:......:::.:.:.||||....:|
Human   715 VLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 779

  Fly   859 ---TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV--AVYFILYHLFVTLIVLSLF 918
               ..|::||.|.|::|||||.|.|.||| ...||:...::..:  |:|||:..||....:|::|
Human   780 TPSANFDTFPAAIMTVFQILTGEDWNEVM-YNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVF 843

  Fly   919 VAVILDNLELDEDIKKLKQLK---FREQSA--EIKETLPFRLRIFEKFPDSPQMTILHRIPNDFM 978
            :|:.:|||...:::.|.:|.:   |.::.|  :.||..|.                  ..||
Human   844 LAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM------------------SAPN--- 887

  Fly   979 LPKV-RESFMKHFVIELETEDS-LVENCKRPMSECWESNV-VFRK-----------------QKP 1023
            :|.: |:...:|.:...|...| |.|..:|.....||... ..||                 ..|
Human   888 MPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNP 952

  Fly  1024 VRIMNKTAKVRAAGS---------SLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG---- 1075
            :..:|..:.:....:         ::..||:...:.....:|:..|.|       .||.||
Human   953 LNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGS-------LKGDGGDRSS 1010

  Fly  1076 -LKSQGTI----THSKPW---------------------------RVDQKKFGSRSIRRSVRSGS 1108
             |.:|.|.    ....||                           |...::...||..|.||:
Human  1011 ALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRT-- 1073

  Fly  1109 IKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRN----------QREEDL 1163
                       |..:.::|.|:.|. ::...||..:.....:..|:|.|          :|.:||
Human  1074 -----------EGKESSSASRSRSA-SQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDL 1126

  Fly  1164 RENHPFF--------------DTPLFLVPRESRFRK----------------------------- 1185
            |..:...              ||||.|...|....|
Human  1127 RRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVI 1191

  Fly  1186 ----------------------------------ICQKIVHAR----------YDARLKDPLTGK 1206
                                              :...:||..          .:|.:::.....
Human  1192 SQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEV 1256

  Fly  1207 ERKVQYK--------------------------SLHNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
            |:|.|.|                          :.|..:.| .|.:..::.....|.|::..|.|
Human  1257 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNL-RYFEMCILLVIAASSIALAAEDP 1320

  Fly  1246 NYRVMD-HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWM 1309
            .....: :..|:..:|.|....:.|:.:|::..||.....:|.:|:...|| |:.||.......:
Human  1321 VLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD-FVVVVGALVAFAL 1384

  Fly  1310 PLNIPTNSAAQL-----LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFA 1369
            ...:.||....:     |.:||.:|||:....:|.::.|...:....|.:..:..:..|.|||||
Human  1385 ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFA 1449

  Fly  1370 SYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVP-RVWANPRRFN 1433
            ...|||:.|:...|.|.:....::|:|.::              |.....|.|. |.|.. ..|:
Human  1450 VIAVQLFKGKFFYCTDSSKDTEKECIGNYV--------------DHEKNKMEVKGREWKR-HEFH 1499

  Fly  1434 FDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVH------AVYIHIYIFLGCMIGLTLFV 1488
            :|||..|:||||.|.:.:||..|.    ||..:..||..      :::..:|..:.....:.:||
Human  1500 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1564

  Fly  1489 GVVIANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQ 1544
            .::|..:.| :|..::     ..|.|:|..:.       |:||  ::|     :....|.|.:..
Human  1565 ALIIITFQE-QGDKMM-----EECSLEKNERACIDFAISAKPLTRYMP-----QNRHTFQYRVWH 1618

  Fly  1545 HII---FKRVIAVVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYW 1605
            .::   |:..|..::.:|:::|.:.:.......| .|..::...|.||.:|.|:|.|||....|:
Human  1619 FVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYF 1683

  Fly  1606 QSRRNRYDLLVTVAGVIWIIL-QTILRNDLSYFFGFMVVI--LRFFTITGKHTTLKMLMLTVGVS 1667
            :...|.:|.:..:..:..||| .:.|.|...:...|:.:.  .|...:..:..|:::|:.|...|
Human  1684 RDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQS 1748

  Fly  1668 VCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKI 1730
            .....::...:.:|.|.||:.|..:||.:|..|  .|.|..||.|....:.:|||..|||.|.:|
Human  1749 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEI 1813

  Fly  1731 MHDCMVQ---PPYCTLGNNYWETD-CGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN 1791
            |..|:.:   .|..|..:...|.: ||...| .:||.:|....::::|||.||:||:||.  |..
Human  1814 MLSCLGEKGCEPDTTAPSGQNENERCGTDLA-YVYFVSFIFFCSFLMLNLFVAVIMDNFE--YLT 1875

  Fly  1792 EEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCY 1852
            .:.::|....:..|...|...|....|.|....:..:|.|:...|    .| |.|       :.|
Human  1876 RDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRC-PSK-------VAY 1932

  Fly  1853 ELDKLHN---GEDVTFH--DVINMLSYRSVDIRKA------------LQLEEL-----LAREEFE 1895
            :...|.|   .||:|.|  ..:..|...::||:.|            ||.|.|     |:::..:
Human  1933 KRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD 1997

  Fly  1896 YLVE----------EEVAKMTIRTWLEGCLKKIRAQNASKQQN----------SL---------- 1930
            .||.          :..|.|.|..:.:....|.:.|...:|:|          ||
Human  1998 LLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKA 2062

  Fly  1931 --------IAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSST 1987
                    ::||...:..|.|.|...:|...|..:|                |..|.   .|...
Human  2063 LPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMD----------------PADDG---QFQER 2108

  Fly  1988 ENEEKDGSSSAVVQ-------LPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMT 2045
            ::.|.:.|....||       ||......||:|.::        :...|.|.|..|...:..
Human  2109 QSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRAS--------SMPRLTVDPQVVTDPSSM--- 2162

  Fly  2046 VGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQ 2110
              :|.::..|...:.||...:|....||:    :|...:.|.:.:|.:...:.:.:  .:|....
Human  2163 --RRSFSTIRDKRSNSSWLEEFSMERSSE----NTYKSRRRSYHSSLRLSAHRLNS--DSGHKSD 2219

  Fly  2111 LAKQRGGGGEATKS-------SSFFAQLNSE 2134
              ..|.||.|..:|       |...::.|||
Human  2220 --THRSGGRERGRSKERKHLLSPDVSRCNSE 2248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	71/317 (22%)
		Ion_trans	705..927	CDD:459842	70/236 (30%)
		Ion_trans	1224..1497	CDD:459842	70/289 (24%)
		Ion_trans	1545..1793	CDD:459842	72/260 (28%)
CACNA1E	XP_016857732.1	Ion_trans	233..507	CDD:459842	81/368 (22%)
		Ion_trans	620..859	CDD:459842	71/243 (29%)
		Ion_trans	1298..1532	CDD:459842	64/249 (26%)
		Ion_trans	1622..1879	CDD:459842	72/259 (28%)
		GPHH	1888..1941	CDD:465306	14/60 (23%)
		Ca_chan_IQ	1951..2027	CDD:462591	14/75 (19%)
		PHA03307	2123..>2345	CDD:223039	29/147 (20%)