DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and CACNA1E

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_016857732.1 Gene:CACNA1E / 777 HGNCID:1392 Length:2458 Species:Homo sapiens


Alignment Length:2241 Identity:470/2241 - (20%)
Similarity:804/2241 - (35%) Gaps:651/2241 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 IATGIGNKIMLGRKQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLN 376
            :||.|.|.|:|..:|.|           ||:                          ..|.:|..
Human   241 LATIIANCIVLALEQHL-----------PED--------------------------DKTPMSRR 268

  Fly   377 TPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWIS 441
            ..|| |.|    ||.         :|..|...|:...|.:..:..||::.|...|..:|    :|
Human   269 LEKT-EPY----FIG---------IFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVV----LS 315

  Fly   442 IIL-------------------QIFEVLEIVPKFSYL-----SIMRAPRPLIMIRFLRVFLKFSM 482
            .||                   ::...|::|.....|     |||:|..||:.|..|        
Human   316 GILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLL-------- 372

  Fly   483 PKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINS 546
                                |||...|  :.::|::|: |:|...|.|||:              
Human   373 --------------------LFFAILM--FAIIGLEFYSGKLHRACFMNNS-------------- 401

  Fly   547 LAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYR 611
             .|.:.|....|.....|..|..|  .|::... .|...|::|..::.||:|..:.|||..::|.
Human   402 -GILEGFDPPHPCGVQGCPAGYEC--KDWIGPN-DGITQFDNILFAVLTVFQCITMEGWTTVLYN 462

  Fly   612 AIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSG 676
            ..|:|.|.....||..:|...::.|.|:.:.|::..|.:.|.:.:.    |....|....|.:..
Human   463 TNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVEN----RRAFMKLRRQQQIER 523

  Fly   677 NDTGWR--------LVTIDDNKHGGL-----------------------APETC----------- 699
            ...|:|        ::..::||:.|.                       :.|.|           
Human   524 ELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLA 588

  Fly   700 --------------------------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVF 738
                                      ..:::|..|..:|:|::..|   ||.:...|..:|:.:.
Human   589 RASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALN---TACVAIVHHNQPQWLT 650

  Fly   739 YERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV-PMFYPS---GLT 799
            : ..||.|.:|..|..||...|:|.:|.|.|:..|.:.|:..:..|:...:| .:|.|.   |::
Human   651 H-LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGIS 714

  Fly   800 YFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF--- 858
            ..:.||::|:.|.:   ..|...|..:....|.:.||:......:::.:.:.||||....:|   
Human   715 VLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 779

  Fly   859 ---TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV--AVYFILYHLFVTLIVLSLF 918
               ..|::||.|.|::|||||.|.|.||| ...||:...::..:  |:|||:..||....:|::|
Human   780 TPSANFDTFPAAIMTVFQILTGEDWNEVM-YNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVF 843

  Fly   919 VAVILDNLELDEDIKKLKQLK---FREQSA--EIKETLPFRLRIFEKFPDSPQMTILHRIPNDFM 978
            :|:.:|||...:::.|.:|.:   |.::.|  :.||..|.                  ..||   
Human   844 LAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM------------------SAPN--- 887

  Fly   979 LPKV-RESFMKHFVIELETEDS-LVENCKRPMSECWESNV-VFRK-----------------QKP 1023
            :|.: |:...:|.:...|...| |.|..:|.....||... ..||                 ..|
Human   888 MPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNP 952

  Fly  1024 VRIMNKTAKVRAAGS---------SLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG---- 1075
            :..:|..:.:....:         ::..||:...:.....:|:..|.|       .||.||    
Human   953 LNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGS-------LKGDGGDRSS 1010

  Fly  1076 -LKSQGTI----THSKPW---------------------------RVDQKKFGSRSIRRSVRSGS 1108
             |.:|.|.    ....||                           |...::...||..|.||:  
Human  1011 ALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRT-- 1073

  Fly  1109 IKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRN----------QREEDL 1163
                       |..:.::|.|:.|. ::...||..:.....:..|:|.|          :|.:||
Human  1074 -----------EGKESSSASRSRSA-SQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDL 1126

  Fly  1164 RENHPFF--------------DTPLFLVPRESRFRK----------------------------- 1185
            |..:...              ||||.|...|....|                             
Human  1127 RRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVI 1191

  Fly  1186 ----------------------------------ICQKIVHAR----------YDARLKDPLTGK 1206
                                              :...:||..          .:|.:::.....
Human  1192 SQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEV 1256

  Fly  1207 ERKVQYK--------------------------SLHNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
            |:|.|.|                          :.|..:.| .|.:..::.....|.|::..|.|
Human  1257 EKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNL-RYFEMCILLVIAASSIALAAEDP 1320

  Fly  1246 NYRVMD-HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWM 1309
            .....: :..|:..:|.|....:.|:.:|::..||.....:|.:|:...|| |:.||.......:
Human  1321 VLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILD-FVVVVGALVAFAL 1384

  Fly  1310 PLNIPTNSAAQL-----LMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFA 1369
            ...:.||....:     |.:||.:|||:....:|.::.|...:....|.:..:..:..|.|||||
Human  1385 ANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFA 1449

  Fly  1370 SYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVP-RVWANPRRFN 1433
            ...|||:.|:...|.|.:....::|:|.::              |.....|.|. |.|.. ..|:
Human  1450 VIAVQLFKGKFFYCTDSSKDTEKECIGNYV--------------DHEKNKMEVKGREWKR-HEFH 1499

  Fly  1434 FDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGPVH------AVYIHIYIFLGCMIGLTLFV 1488
            :|||..|:||||.|.:.:||..|.    ||..:..||..      :::..:|..:.....:.:||
Human  1500 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1564

  Fly  1489 GVVIANYSENKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQ 1544
            .::|..:.| :|..::     ..|.|:|..:.       |:||  ::|     :....|.|.:..
Human  1565 ALIIITFQE-QGDKMM-----EECSLEKNERACIDFAISAKPLTRYMP-----QNRHTFQYRVWH 1618

  Fly  1545 HII---FKRVIAVVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYW 1605
            .::   |:..|..::.:|:::|.:.:.......| .|..::...|.||.:|.|:|.|||....|:
Human  1619 FVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYF 1683

  Fly  1606 QSRRNRYDLLVTVAGVIWIIL-QTILRNDLSYFFGFMVVI--LRFFTITGKHTTLKMLMLTVGVS 1667
            :...|.:|.:..:..:..||| .:.|.|...:...|:.:.  .|...:..:..|:::|:.|...|
Human  1684 RDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQS 1748

  Fly  1668 VCKSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKI 1730
            .....::...:.:|.|.||:.|..:||.:|..|  .|.|..||.|....:.:|||..|||.|.:|
Human  1749 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEI 1813

  Fly  1731 MHDCMVQ---PPYCTLGNNYWETD-CGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSN 1791
            |..|:.:   .|..|..:...|.: ||...| .:||.:|....::::|||.||:||:||.  |..
Human  1814 MLSCLGEKGCEPDTTAPSGQNENERCGTDLA-YVYFVSFIFFCSFLMLNLFVAVIMDNFE--YLT 1875

  Fly  1792 EEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCY 1852
            .:.::|....:..|...|...|....|.|....:..:|.|:...|    .| |.|       :.|
Human  1876 RDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRC-PSK-------VAY 1932

  Fly  1853 ELDKLHN---GEDVTFH--DVINMLSYRSVDIRKA------------LQLEEL-----LAREEFE 1895
            :...|.|   .||:|.|  ..:..|...::||:.|            ||.|.|     |:::..:
Human  1933 KRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD 1997

  Fly  1896 YLVE----------EEVAKMTIRTWLEGCLKKIRAQNASKQQN----------SL---------- 1930
            .||.          :..|.|.|..:.:....|.:.|...:|:|          ||          
Human  1998 LLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKA 2062

  Fly  1931 --------IAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSST 1987
                    ::||...:..|.|.|...:|...|..:|                |..|.   .|...
Human  2063 LPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMD----------------PADDG---QFQER 2108

  Fly  1988 ENEEKDGSSSAVVQ-------LPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMT 2045
            ::.|.:.|....||       ||......||:|.::        :...|.|.|..|...:..   
Human  2109 QSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRAS--------SMPRLTVDPQVVTDPSSM--- 2162

  Fly  2046 VGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQ 2110
              :|.::..|...:.||...:|....||:    :|...:.|.:.:|.:...:.:.:  .:|....
Human  2163 --RRSFSTIRDKRSNSSWLEEFSMERSSE----NTYKSRRRSYHSSLRLSAHRLNS--DSGHKSD 2219

  Fly  2111 LAKQRGGGGEATKS-------SSFFAQLNSE 2134
              ..|.||.|..:|       |...::.|||
Human  2220 --THRSGGRERGRSKERKHLLSPDVSRCNSE 2248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 70/305 (23%)
Ion_trans 734..927 CDD:278921 62/207 (30%)
Ion_trans 1240..1497 CDD:278921 67/273 (25%)
Ion_trans 1571..1793 CDD:278921 68/231 (29%)
CACNA1EXP_016857732.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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