DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and CACNA1D

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_011532396.1 Gene:CACNA1D / 776 HGNCID:1391 Length:2246 Species:Homo sapiens


Alignment Length:2049 Identity:440/2049 - (21%)
Similarity:784/2049 - (38%) Gaps:640/2049 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   369 SLTSVSLNTP-----------KTFERYPSLQ----------FITFASDT-------------AVT 399
            :|..:|||.|           |.|:.:..|.          :|.|..|.             |..
Human   142 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFL 206

  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV-LEIVPK-------- 455
            ::||.|...|:...|:|.....|:::.|...|       ::.:|:.:|.| ||.:.|        
Human   207 IIFTVETFLKIIAYGLLLHPNAYVRNGWNLLD-------FVIVIVGLFSVILEQLTKETEGGNHS 264

  Fly   456 --------FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMS 510
                    ...|...|..|||.::.        .:|..::  |.|.| :...:.::.|..||.:.
Human   265 SGKSGGFDVKALRAFRVLRPLRLVS--------GVPSLQVVLNSIIK-AMVPLLHIALLVLFVII 320

  Fly   511 LYGLLGVQ-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSP-GMVCMKM 573
            :|.::|:: |.|::...|...:::....:.|        .|..|..    :|.||:. |..|   
Human   321 IYAIIGLELFIGKMHKTCFFADSDIVAEEDP--------APCAFSG----NGRQCTANGTEC--- 370

  Fly   574 DFLSSYVIGFNG----FEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTMIF 630
               .|..:|.||    |::.|.::.||:|..:.|||..::|...|:    || |   .||.:::.
Human   371 ---RSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELP-W---VYFVSLVI 428

  Fly   631 FLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQKTAASQIL--------------------- 674
            |.::.|.|:.:.|::..|::.|.:.:    |||..||....|.|                     
Human   429 FGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPEN 489

  Fly   675 --SGNDTGWRLVTIDDNKHGGLAPET--------------------------------------- 698
              .|.:.|.|..::..::...:..|.                                       
Human   490 EEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRRWGQAIS 554

  Fly   699 ------------------CHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRP------RDVFY 739
                              |.|.::|..|..||:.::..|   |.|::.:|..:|      :|:..
Human   555 KSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLN---TLTISSEHYNQPDWLTQIQDIAN 616

  Fly   740 ERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIVPMFYPSGLTY 800
            :   .:..:|||    |.|.|:|.||.:.|:....::|:..:..|    |.|..:.:..|.|::.
Human   617 K---VLLALFTC----EMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISV 674

  Fly   801 FQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF---- 858
            |:.:|::|:.|.:   ..|...|..:....|.:.||::.....:||.|.:.||||....:|    
Human   675 FRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQ 739

  Fly   859 TK---FESFPEAFMSMFQILTQEAWVEVMDETMIR----TSKTLTPLVAVYFILYHLFVTLIVLS 916
            ||   |::||:|.:::|||||.|.|..||.:.::.    :|..:  :|.:|||:..:....|:|:
Human   740 TKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGM--IVCIYFIILFICGNYILLN 802

  Fly   917 LFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPK 981
            :|:|:.:|||   .|.:.|...:..|...:.::.:..:..:..|..:.|::..:....|...:..
Human   803 VFLAIAVDNL---ADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDD 864

  Fly   982 VRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAIT 1046
            .||          |.||      |.|...|         ..||.                     
Human   865 YRE----------EDED------KDPYPPC---------DVPVG--------------------- 883

  Fly  1047 HIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKL 1111
                                                                             
Human   884 ----------------------------------------------------------------- 883

  Fly  1112 KQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFL 1176
            ::..|...:..::.|.||                  .|:.:|:...::...:.|...|     |:
Human   884 EEEEEEEEDEPEVPAGPR------------------PRRISELNMKEKIAPIPEGSAF-----FI 925

  Fly  1177 VPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMM 1241
            :.:.:..|..|.|:::.                      |.|..|:  |.::|     ||..::.
Human   926 LSKTNPIRVGCHKLINH----------------------HIFTNLI--LVFIM-----LSSAALA 961

  Fly  1242 FETP----NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVS 1302
            .|.|    ::|   :..|...:|.|....::|:.||:...|.|....|:.::....||:.:..||
Human   962 AEDPIRSHSFR---NTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS 1023

  Fly  1303 TSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILL 1364
               |....:.....|..::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||
Human  1024 ---LVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTT---LL 1082

  Fly  1365 MFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANP 1429
            .|:||..||||:.|:..||.|...|..|:|.|:|:         |....|...| ::..|:|.| 
Human  1083 QFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI---------LYKDGDVDSP-VVRERIWQN- 1136

  Fly  1430 RRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKA-------VGPVH------AVYIHIYIFLGCM 1481
            ..|||||:..||:.||.|.:|:||   ..:|.||       :||::      :::..|||.:...
Human  1137 SDFNFDNVLSAMMALFTVSTFEGW---PALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAF 1198

  Fly  1482 IGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIR 1536
            ..:.:|||.||..:.| :|.     .:.:.|:|.|.        || |:||  ::|..|...|  
Human  1199 FMMNIFVGFVIVTFQE-QGE-----KEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNPYQYK-- 1254

  Fly  1537 AFTYDITQHIIFKRVIAVVVLINSMLLSIT-WIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFT 1600
             |.| :.....|:.::.|::::|::.|::. :.:.::..:.:.|::.|.|.||.||:|:|.|||.
Human  1255 -FWY-VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK 1317

  Fly  1601 PRGYWQSRRNRYDLLVTVAGVI--------------W------IILQTIL--------------- 1630
            |:||:....|.:|.|:.:..:|              |      |::.:::               
Human  1318 PKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENV 1382

  Fly  1631 ------------RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSF----FIIFGMF 1679
                        .|.:|..|..:..::|...:..:...::.|:.|    ..|||    ::...:.
Human  1383 PVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT----FIKSFQALPYVALLIA 1443

  Fly  1680 LLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCT 1742
            :|.|.||:.|..:||.|...:.  |.|..||.:....|.:|||..|||.|.:||..|: ....|.
Human  1444 MLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL-PGKLCD 1507

  Fly  1743 LGNNY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIR 1803
            ..::|   .|..|| ||  :::||.:||::..::::||.||:||:||.  |...:.::|....:.
Human  1508 PESDYNPGEEYTCGSNF--AIVYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHLD 1568

  Fly  1804 NFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKLH 1858
            .|:..|:..|...:|       |..:||::..|   :|...|:.|    .||:...|     .|:
Human  1569 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC----KRLVAMNM-----PLN 1624

  Fly  1859 NGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIR--------------- 1908
            :...|.|:..:..|...::.|:....||:  |.||...::::...|.:::               
Human  1625 SDGTVMFNATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVT 1687

  Fly  1909 ------TWL-------------EGCLKKIRAQNASKQQNSLIAGLRATNE-QPVMRP----NIQE 1949
                  |:|             :|.:.|..|:|.:   .:|.||||..:: .|.:|.    ::|:
Human  1688 VGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTT---IALQAGLRTLHDIGPEIRRAISCDLQD 1749

  Fly  1950 DK-APLGAVDKSAISTISGAVAG-----------------------------ACPPTSDAFSPTF 1984
            |: ......::..:...:||:.|                             :.||.||...|.|
Human  1750 DEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLF 1814

  Fly  1985 SSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKR 2049
            ....|        :|....|:..||        |....|.|::.|.   ....|.|.|    |||
Human  1815 PPAGN--------SVCHNHHNHNSI--------GKQVPTSTNANLN---NANMSKAAH----GKR 1856

  Fly  2050 GYA--LNRSDSTGSSAGRKFLAPTSSDPQQRSTL 2081
            ...  |......|..:..|.    ..:||:||::
Human  1857 PSIGNLEHVSENGHHSSHKH----DREPQRRSSV 1886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 76/343 (22%)
Ion_trans 734..927 CDD:278921 61/216 (28%)
Ion_trans 1240..1497 CDD:278921 81/276 (29%)
Ion_trans 1571..1793 CDD:278921 73/278 (26%)
CACNA1DXP_011532396.1 Ion_trans 180..454 CDD:278921 69/311 (22%)
Ion_trans 600..817 CDD:278921 64/228 (28%)
Ion_trans 960..1219 CDD:278921 83/287 (29%)
Ion_trans 1279..1560 CDD:278921 74/289 (26%)
GPHH 1568..1631 CDD:293510 16/71 (23%)
Ca_chan_IQ 1633..1704 CDD:285917 10/72 (14%)
CAC1F_C 1728..2243 CDD:293490 38/186 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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