Protein Alignment na and CACNA1C

DIOPT Version :9

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_016875415.1
• Gene: CACNA1C / 775
• HGNCID: 1390
• Length: 2412
• Species: Homo sapiens
• Alignment Length: 2327
• Identity: 488/2327 - (20%)
• Similarity: 842/2327 - (36%)
• Gaps: 785/2327 - (33%)

  Fly   173 FNPSPGSSP--GNGLGLGARQDAASALNSPTTIVNSGSGSGGGSSVAFGMQPQQQQQSLAGGGGG 235
            |..|||.||  .:.:...:...:......||...|.||             |:....::......
Human    41 FYISPGESPVRTSSVQTPSHPTSTEPCGPPTLCSNYGS-------------PRPAHANMNANAAA 92

  Fly   236 GSSATAAPSSGGGHNNGAGLGPVVGGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISST---- 296
            |.:....|:.|...:..|.:     .......|:|             :||......:|||
Human    93 GLAPEHIPTPGAALSWQAAI-----DAARQAKLMG-------------SAGNATISTVSSTQRKR 139

  Fly   297 --------VGSAAITGVPPIGLGIATGIGNKIMLGRKQ--SLKGGEPF--------------LAD 337
                    .||...|. ||..| :...:.|.|   |:.  |:...:||              ||.
Human   140 QQYGKPKKQGSTTATR-PPRAL-LCLTLKNPI---RRACISIVEWKPFEIIILLTIFANCVALAI 199

  Fly   338 YGP---EESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVT 399
            |.|   ::|...::::|.|..|::
Human   200 YIPFPEDDSNATNSNLERVEYLFL----------------------------------------- 223

  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFE-VLEIVPKFSYLSIM- 462
            ::||.|...|:...|:|.....||::.|...|       :|.:::.:|. :||...|....:.:
Human   224 IIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLD-------FIIVVVGLFSAILEQATKADGANALG 281

  Fly   463 --------RAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGV 517
                    :|.|...::|.||  |...:|..::  |.|.| :...:.::.|..||.:.:|.::|:
Human   282 GKGAGFDVKALRAFRVLRPLR--LVSGVPSLQVVLNSIIK-AMVPLLHIALLVLFVIIIYAIIGL 343

  Fly   518 Q-FFGELKNHCVMNNTEYDLYKRPILTINSLAIPD-------TFCSMDPDSGYQCSPGMVCMKMD 574
            : |.|::...|                .|...|.|       :.|:::...|.||..|.||..
Human   344 ELFMGKMHKTC----------------YNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP-- 390

  Fly   575 FLSSYVIGFNG-------FEDIATSIFTVYQAASQEGWVFIMYRAIDS----LPAWRAAFYFSTM 628
                   |::|       |::.|.::.||:|..:.|||..::|...|:    || |   .||.::
Human   391 -------GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELP-W---VYFVSL 444

  Fly   629 IFFLAWLVKNVFIAVITETFNEIRVQFQQMWGARGHIQK------------------TAASQI-- 673
            :.|.::.|.|:.:.|::..|::.|.:.:    |||..||                  |.|..|
Human   445 VIFGSFFVLNLVLGVLSGEFSKEREKAK----ARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 505

  Fly   674 -----------------------------------------------------------LSGNDT 679
                                                                       :.|.:.
Human   506 ENEDEGMDEEKPRNRGTPAGMLDQKKGKFAWFSHSTETHVSMPTSETESVNTENVAGGDIEGENC 570

  Fly   680 G------------------WRLVTIDD------------------------------NKHGGLAP 696
            |                  |.:.|::.                              .:......
Human   571 GARLAKGSRSAVEPAVLLPWGVTTVNSPWPLEELQTEALSQTSPSHRISKSKFSRYWRRWNRFCR 635

  Fly   697 ETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYIELVFT------CLLDL 755
            ..|.|.::|..|..||:.::..|   |.|:..:|..:|.       :..|:..|      .|...
Human   636 RKCRAAVKSNVFYWLVIFLVFLN---TLTIASEHYNQPN-------WLTEVQDTANKALLALFTA 690

  Fly   756 ETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIV----PMFYPSGLTYFQVLRVVRLIKAS--- 813
            |.|.|:|.||.:.|:....::|:..:..|..|..:    .:..|.|::..:.:|::|:.|.:
Human   691 EMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYW 755

  Fly   814 PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF-------TKFESFPEAFMSM 871
            ..|...|..:....:.:.||::.....:||.|.:.||||....:|       :.|::||::.:::
Human   756 NSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 820

  Fly   872 FQILTQEAWVEVMDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDNL-------- 926
            |||||.|.|..||.:.::.......|  ||.:|||:..:....|:|::|:|:.:|||
Human   821 FQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 885

  Fly   927 --ELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKH 989
              :.:|:.|:.|:|. |..|.|.|:.|      .||                   |.|.||  |.
Human   886 AQKEEEEEKERKKLA-RTASPEKKQEL------VEK-------------------PAVGES--KE 922

  Fly   990 FVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSS--LRKLAITHIINDS 1052
            ..|||::                                    :.|.|.|  ..|:.:..:..:.
Human   923 EKIELKS------------------------------------ITADGESPPATKINMDDLQPNE 951

  Fly  1053 NNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEH 1117
            |.      |.:..|...|.|                                           |.
Human   952 NE------DKSPYPNPETTG-------------------------------------------EE 967

  Fly  1118 LMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESR 1182
            ..|..::...||                  .|..:|:...::...:.|...|     |:....:|
Human   968 DEEEPEMPVGPR------------------PRPLSELHLKEKAVPMPEASAF-----FIFSSNNR 1009

  Fly  1183 FRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNY 1247
            ||..|.:||:        |.:              |..|:       :|...||.||:..|.|
Human  1010 FRLQCHRIVN--------DTI--------------FTNLI-------LFFILLSSISLAAEDP-- 1043

  Fly  1248 RVMDHPTLQ--IAEYGFVIF---MSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLC 1307
              :.|.:.:  |..|..::|   .::|:|||:.|.|.|....::.::....||  :.|||.|.:.
Human  1044 --VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILD--LLVVSVSLIS 1104

  Fly  1308 W----MPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVYELCRGFKEILLVSTLLILLM 1365
            :    ..:|:     .::|.:||.:||||....   :.|:.:.|:...|....|::|:|   ||.
Human  1105 FGIQSSAINV-----VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT---LLQ 1161

  Fly  1366 FIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPR 1430
            |:||..||||:.|:|..|:|.:.....:|.|.:          :|....|....::.||.|.| .
Human  1162 FMFACIGVQLFKGKLYTCSDSSKQTEAECKGNY----------ITYKDGEVDHPIIQPRSWEN-S 1215

  Fly  1431 RFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GPVH------AVYIHIYIFLGCMI 1482
            :|:|||:..||:.||.|.:|:||   .::|.:::       ||::      :::..|||.:....
Human  1216 KFDFDNVLAAMMALFTVSTFEGW---PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 1277

  Fly  1483 GLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIRA 1537
            .:.:|||.||..:.| :|.     .:.:.|:|.|.        || |:||  ::|......|:
Human  1278 MMNIFVGFVIVTFQE-QGE-----QEYKNCELDKNQRQCVEYALK-ARPLRRYIPKNQHQYKV-- 1333

  Fly  1538 FTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLV--IVSAVLTFVFVVEVVMKNIAFT 1600
              :.:.....|:.::.|::|:|::.|::... |:....::.  |::.:.|.:|.||:::|.|||.
Human  1334 --WYVVNSTYFEYLMFVLILLNTICLAMQHY-GQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1395

  Fly  1601 PRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFF-------------GFMV---------- 1642
            |:||:....|.:|.|:.:..:|.:||     ::.:::|             |.:|
Human  1396 PKGYFSDPWNVFDFLIVIGSIIDVIL-----SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPA 1455

  Fly  1643 ----------------VILRFFTITGKHTTLKMLMLTVGV-----SVCKSF----FIIFGMFLLV 1682
                            :.:.||.:......:|:|....|:     :..|||    ::...:.:|.
Human  1456 EHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLF 1520

  Fly  1683 FFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM--------VQ 1737
            |.||:.|..:||.:...:  .|.|..||.:....|.:|||..|||.|..||..||        .:
Human  1521 FIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1585

  Fly  1738 PPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADI 1802
            |...|.|    ||.||: :.::.||.:||::..::::||.||:||:||.  |...:.::|....:
Human  1586 PSNSTEG----ETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDWSILGPHHL 1643

  Fly  1803 RNFQNTWNIVDIHQRG-------VIPVRRVKFIL---RLLKGRLECDPQKDRLLFKYMCYELDKL 1857
            ..|:..|...|...:|       |..:||::..|   :|...|:.|    .||:...|     .|
Human  1644 DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC----KRLVSMNM-----PL 1699

  Fly  1858 HNGEDVTFHDVINMLSYRSVDI-------------------RKALQLEELLAREEFEYLV----- 1898
            ::...|.|:..:..|...::.|                   |.|..||:  |.||...::
Human  1700 NSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQ--ANEELRAIIKKIWK 1762

  Fly  1899 -----------------EEEVAKMTIRTWLEGCLKKIRAQNAS------KQQN--SLIAGLRATN 1938
                             |..|.|......::...:|.:.:...      .|:|  ||.||||..:
Human  1763 RTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLH 1827

  Fly  1939 E-QPVMRPNIQEDKAPLGAVDKSAISTISGAV-------AGAC---------PPTSDAFSPTFSS 1986
            : .|.:|..|..|......:||:....:|.|.       ||..         .....||..||::
Human  1828 DIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1892

  Fly  1987 TE--NEEKDGSSSAVVQLPHSE---------TSIAGTGSSA---TGAATATG-----------TS 2026
            ..  :..|.|||....:.|..|         :|.:.|||:|   ....||.|           .|
Human  1893 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVS 1957

  Fly  2027 SGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKF---LAPTSSDP 2075
            :..|.|||.  |.|..|..|..: .:.||........|..|   |.|..:.|
Human  1958 TVEGHGPPL--SPAIRVQEVAWK-LSSNRMHCCDMLDGGTFPPALGPRRAPP 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	66/311 (21%)
		Ion_trans	734..927	CDD:278921	56/224 (25%)
		Ion_trans	1240..1497	CDD:278921	77/281 (27%)
		Ion_trans	1571..1793	CDD:278921	72/281 (26%)
CACNA1C	XP_016875415.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950