DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and CACNA1B

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens


Alignment Length:2370 Identity:516/2370 - (21%)
Similarity:869/2370 - (36%) Gaps:628/2370 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 GAGLGPVVGGGGGGLNLL-GGLGGMGGMGGGAAAAGMGI------------------------CG 291
            |..||...||.|||.... ||.||.||.|.|....|..:                        |.
Human     5 GDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCF 69

  Fly   292 GISSTV-----------GSAAITGVPPIG-LGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESL 344
            .::.::           .:..||..||.. :.:||.|.|.|:|..:|.|..|:            
Human    70 TVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGD------------ 122

  Fly   345 NESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ--FITFASDTAVTLLFTAEMI 407
                                           .||.: ||....:  ||.         :|..|..
Human   123 -------------------------------KTPMS-ERLDDTEPYFIG---------IFCFEAG 146

  Fly   408 AKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM-- 470
            .|:...|.:..:..||::.|...|       ::.::..|............|..:|..|||.:  
Human   147 IKIIALGFVFHKGSYLRNGWNVMD-------FVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVS 204

  Fly   471 -IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTE 533
             |..|:|.|| |:.|:.:         .:..:.|...|.:.::.::|::|: |:....|..|:|:
Human   205 GIPSLQVVLK-SIMKAMV---------PLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTD 259

  Fly   534 YDLYKRPILTINSLAIPDTFCSMDPDSGYQC---SPGMVCMK----MDFLSSYVIGFNGFEDIAT 591
                                  .:|...:.|   :|..:|..    .::......|...|::|..
Human   260 ----------------------AEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILF 302

  Fly   592 SIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT----------- 645
            :|.||:|..:.|||..|:|...|:........||..:|...::.:.|:.:.|::           
Human   303 AILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367

  Fly   646 --ETFNEIRVQFQQMWGARGHIQ--------------------------KTAASQILSGNDTGWR 682
              ..|.::|.|.|......|:::                          |.||:: .|.||    
Human   368 NRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATK-KSRND---- 427

  Fly   683 LVTIDDNKHG-----GLAPETCHAILR------SPYFR--------------------MLVMSVI 716
            |:..::.:..     .:......|.|:      |.|||                    .:|:.|:
Human   428 LIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVV 492

  Fly   717 LANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLL 781
            ..|.:..|.:   |..:||.: ....|:.|.||..|...|...|:|.||.|.|::.|.:.|:..:
Human   493 ALNTLCVAMV---HYNQPRRL-TTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGV 553

  Fly   782 AAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMC 839
            ..|:...:| ....|.   |::..:.||::|:.|.:   ..|...|..:....|.:.||:.....
Human   554 IVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFL 618

  Fly   840 LLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVM---DETMIRTSKTL 895
            .:::.:.:.||||....:|      |.|::||.|.:::|||||.|.|..||   .|:....||.:
Human   619 FIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGM 683

  Fly   896 TPLVAVYFILYHLFVTLIVLSLFVAVILDNL----ELDEDIKKLKQL---KFREQSA-EIKETLP 952
              ..:.|||:..||....:|::|:|:.:|||    ||.:|.:::::.   |...|.| |:.|..|
Human   684 --FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSP 746

  Fly   953 F--------------------------RLRIFEKFPDSPQMTILHRIPND--------FMLPKVR 983
            .                          :||: :....|.:.......|.:        .:.|.::
Human   747 MSAANISIAARQQNSAKARSVWEQRASQLRL-QNLRASCEALYSEMDPEERLRFATTRHLRPDMK 810

  Fly   984 ESFMKHFVIELETEDSL--VENCKRP-MSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAI 1045
            ....:..|:||..:.:.  |....|| .:|..|.....|:....|..:||.   |||...|..|.
Human   811 THLDRPLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTP---AAGDQDRAEAP 872

  Fly  1046 THIINDSNNQ-------RLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRR- 1102
            .....:...:       |....::|..|...::.|.|...:|...|.:  |...::...|..|| 
Human   873 KAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRRHHR--RGSPEEAAEREPRRH 935

  Fly  1103 --------SVRSGSIKLKQTYEHLMENGDIAAAPR-ANSGR--ARPH-------------DLDIK 1143
                    |......|.::...|   .|...|.|| |.||.  ||.|             :.:..
Human   936 RAHRHQDPSKECAGAKGERRARH---RGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETT 997

  Fly  1144 LLQAKRQQAEMRRNQREEDLRENH----PFFDT---------PLFLVPRESRFRKIC-QKIVHAR 1194
            ..:|..::||:....:|::|| ||    |..|.         |:..:|      ..| ||:....
Human   998 EKEATEKEAEIVEADKEKELR-NHQPREPHCDLETSGTVTVGPMHTLP------STCLQKVEEQP 1055

  Fly  1195 YDA-----------RLKDP---------LTG----------------------KERK-------- 1209
            .||           :..||         |||                      ||.:        
Human  1056 EDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSG 1120

  Fly  1210 ----VQYKSLH------------NFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHP---TL 1255
                |.|.|:.            :::..:.|.:.|::....||.|::..|.| .|. |.|   .|
Human  1121 PRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRT-DSPRNNAL 1183

  Fly  1256 QIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYV----VSTSFLCWMPLNIPTN 1316
            :..:|.|....:.|:.:|::..||...|.||.:|:...|| ||.|    |:.:|......:|.| 
Human  1184 KYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILD-FIVVSGALVAFAFSGSKGKDINT- 1246

  Fly  1317 SAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLA 1381
              .:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.|:..
Human  1247 --IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1309

  Fly  1382 RCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFE 1446
            .|.|.:.....||.|.::             ..|.......||.| ....|::||:..|:||||.
Human  1310 YCTDESKELERDCRGQYL-------------DYEKEEVEAQPRQW-KKYDFHYDNVLWALLTLFT 1360

  Fly  1447 VLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSE 1497
            |.:.:||..|.    |...:..||          .:.||..::.|    ..:.:||.::|..:.|
Human  1361 VSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPF----FFVNIFVALIIITFQE 1421

  Fly  1498 NKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHIIFKRVIA 1553
             :|..:::.     |.|:|..:.       |:||  ::|......:.:.:|:.::..  |:..|.
Human  1422 -QGDKVMSE-----CSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPP--FEYFIM 1478

  Fly  1554 VVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVT 1617
            .::.:|:::|.:.:.......| .|..::.|.|.:|.:|.|:|.|||....|::...|.:| .||
Human  1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD-FVT 1542

  Fly  1618 VAGVIWIILQTIL---RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMF 1679
            |.|.|..||.|.:   .|.::..|..:....|...:..:..|:::|:.|...|.....::...:.
Human  1543 VLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1607

  Fly  1680 LLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCT 1742
            :|.|.||:.|..:||.:...:  .|.|..||.:.:..:.:|||..|||.|::||..|:.......
Human  1608 MLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDE 1672

  Fly  1743 LGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQN 1807
            ..|   .|:||:..| ..||.:|..:.::::|||.||:||:||.  |...:.::|....:..|..
Human  1673 QAN---ATECGSDFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEFIR 1731

  Fly  1808 TWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCYELDKLHNGEDVTFHDV 1868
            .|...|....|.|....:..:|:.:...|    :|..   |:.:|.: ..::...:.||:|.|..
Human  1732 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPA---RVAYKRL-VRMNMPISNEDMTVHFT 1792

  Fly  1869 INMLSYRSVDIRKALQLE-------------EL----------LAREEFEYLV------EEEVAK 1904
            ..:::.    ||.||:::             ||          |.::..:.||      |..|.|
Human  1793 STLMAL----IRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGK 1853

  Fly  1905 MTIRTWLEGCLKKIRAQNASKQQN----------SLIAGLRATNEQPVMRPNI---------QED 1950
            :.....:....|:.:......||.          ||...|:||.||  .:|.:         |:.
Human  1854 VYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQ--TQPAVLRGARVFLRQKS 1916

  Fly  1951 KAPL---GAVDKSAISTISGAVAGACPPTSDA---FSPTFSSTENEE----KDGSSSAVVQLPHS 2005
            ...|   ||:.... |.|..:|:.....|.||   ..|......:.|    :.|:.:..||: .|
Human  1917 STSLSNGGAIQNQE-SGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM-QS 1979

  Fly  2006 ETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGR-KFLA 2069
            .|.....|....|.     .|.|.....|.:.:..:.|....    .:.||.||.:...| ..|.
Human  1980 ITRRGPDGEPQPGL-----ESQGRAASMPRLAAETQPVTDAS----PMKRSISTLAQRPRGTHLC 2035

  Fly  2070 PTSSD---PQQRSTLSDKERLHITSQQRKKNSMT--------------------TLPHAGQLG-- 2109
            .|:.|   |.|.|:.....|.| ..:.||:.|:.                    ..|..|..|  
Human  2036 STTPDRPPPSQASSHHHHHRCH-RRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCR 2099

  Fly  2110 ---QLAKQRGGGGEATKSSSFFAQLNSEIGQFH-------------------YPTINAAAAAAAL 2152
               :..::||...|..:.||    .:||..:|:                   :||...|......
Human  2100 RERERRQERGRSQERRQPSS----SSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP 2160

  Fly  2153 HGYGHGHGHGH-----GGHGGHGGHGEHQM 2177
            |..|.|..:|.     .|....|..|..|:
Human  2161 HPQGSGSVNGSPLLSTSGASTPGRGGRRQL 2190

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 59/306 (19%)
Ion_trans 734..927 CDD:278921 62/212 (29%)
Ion_trans 1240..1497 CDD:278921 75/277 (27%)
Ion_trans 1571..1793 CDD:278921 68/227 (30%)
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 16/31 (52%)
I 82..359 70/368 (19%)
Ion_trans 112..367 CDD:278921 61/346 (18%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 2/16 (13%)
II 468..712 65/249 (26%)
Ion_trans 499..720 CDD:278921 66/226 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 51/230 (22%)
DUF3628 <822..929 CDD:289100 22/111 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 4/21 (19%)
III 1137..1419 80/305 (26%)
Ion_trans 1167..1425 CDD:278921 77/282 (27%)
IV 1456..1711 70/261 (27%)
Ion_trans 1488..1719 CDD:278921 69/237 (29%)
GPHH 1727..1791 CDD:293510 13/67 (19%)
Ca_chan_IQ 1793..1867 CDD:285917 13/77 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 45/224 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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