Protein Alignment na and CACNA1B

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_000709.1
• Gene: CACNA1B / 774
• HGNCID: 1389
• Length: 2339
• Species: Homo sapiens
• Alignment Length: 2370
• Identity: 516/2370 - (21%)
• Similarity: 869/2370 - (36%)
• Gaps: 628/2370 - (26%)

  Fly   252 GAGLGPVVGGGGGGLNLL-GGLGGMGGMGGGAAAAGMGI------------------------CG 291
            |..||...||.|||.... ||.||.||.|.|....|..:                        |.
Human     5 GDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCF 69

  Fly   292 GISSTV-----------GSAAITGVPPIG-LGIATGIGNKIMLGRKQSLKGGEPFLADYGPEESL 344
            .::.::           .:..||..||.. :.:||.|.|.|:|..:|.|..|:
Human    70 TVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGD------------ 122

  Fly   345 NESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQ--FITFASDTAVTLLFTAEMI 407
                                           .||.: ||....:  ||.         :|..|..
Human   123 -------------------------------KTPMS-ERLDDTEPYFIG---------IFCFEAG 146

  Fly   408 AKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM-- 470
            .|:...|.:..:..||::.|...|       ::.::..|............|..:|..|||.:
Human   147 IKIIALGFVFHKGSYLRNGWNVMD-------FVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVS 204

  Fly   471 -IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNNTE 533
             |..|:|.|| |:.|:.:         .:..:.|...|.:.::.::|::|: |:....|..|:|:
Human   205 GIPSLQVVLK-SIMKAMV---------PLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTD 259

  Fly   534 YDLYKRPILTINSLAIPDTFCSMDPDSGYQC---SPGMVCMK----MDFLSSYVIGFNGFEDIAT 591
                                  .:|...:.|   :|..:|..    .::......|...|::|..
Human   260 ----------------------AEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILF 302

  Fly   592 SIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVIT----------- 645
            :|.||:|..:.|||..|:|...|:........||..:|...::.:.|:.:.|::
Human   303 AILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367

  Fly   646 --ETFNEIRVQFQQMWGARGHIQ--------------------------KTAASQILSGNDTGWR 682
              ..|.::|.|.|......|:::                          |.||:: .|.||
Human   368 NRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATK-KSRND---- 427

  Fly   683 LVTIDDNKHG-----GLAPETCHAILR------SPYFR--------------------MLVMSVI 716
            |:..::.:..     .:......|.|:      |.|||                    .:|:.|:
Human   428 LIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVV 492

  Fly   717 LANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLL 781
            ..|.:..|.:   |..:||.: ....|:.|.||..|...|...|:|.||.|.|::.|.:.|:..:
Human   493 ALNTLCVAMV---HYNQPRRL-TTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGV 553

  Fly   782 AAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMC 839
            ..|:...:| ....|.   |::..:.||::|:.|.:   ..|...|..:....|.:.||:.....
Human   554 IVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFL 618

  Fly   840 LLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVM---DETMIRTSKTL 895
            .:::.:.:.||||....:|      |.|::||.|.:::|||||.|.|..||   .|:....||.:
Human   619 FIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGM 683

  Fly   896 TPLVAVYFILYHLFVTLIVLSLFVAVILDNL----ELDEDIKKLKQL---KFREQSA-EIKETLP 952
              ..:.|||:..||....:|::|:|:.:|||    ||.:|.:::::.   |...|.| |:.|..|
Human   684 --FSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSP 746

  Fly   953 F--------------------------RLRIFEKFPDSPQMTILHRIPND--------FMLPKVR 983
            .                          :||: :....|.:.......|.:        .:.|.::
Human   747 MSAANISIAARQQNSAKARSVWEQRASQLRL-QNLRASCEALYSEMDPEERLRFATTRHLRPDMK 810

  Fly   984 ESFMKHFVIELETEDSL--VENCKRP-MSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAI 1045
            ....:..|:||..:.:.  |....|| .:|..|.....|:....|..:||.   |||...|..|.
Human   811 THLDRPLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTP---AAGDQDRAEAP 872

  Fly  1046 THIINDSNNQ-------RLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRR- 1102
            .....:...:       |....::|..|...::.|.|...:|...|.:  |...::...|..||
Human   873 KAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRRHHR--RGSPEEAAEREPRRH 935

  Fly  1103 --------SVRSGSIKLKQTYEHLMENGDIAAAPR-ANSGR--ARPH-------------DLDIK 1143
                    |......|.::...|   .|...|.|| |.||.  ||.|             :.:..
Human   936 RAHRHQDPSKECAGAKGERRARH---RGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETT 997

  Fly  1144 LLQAKRQQAEMRRNQREEDLRENH----PFFDT---------PLFLVPRESRFRKIC-QKIVHAR 1194
            ..:|..::||:....:|::|| ||    |..|.         |:..:|      ..| ||:....
Human   998 EKEATEKEAEIVEADKEKELR-NHQPREPHCDLETSGTVTVGPMHTLP------STCLQKVEEQP 1055

  Fly  1195 YDA-----------RLKDP---------LTG----------------------KERK-------- 1209
            .||           :..||         |||                      ||.:
Human  1056 EDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSG 1120

  Fly  1210 ----VQYKSLH------------NFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHP---TL 1255
                |.|.|:.            :::..:.|.:.|::....||.|::..|.| .|. |.|   .|
Human  1121 PRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRT-DSPRNNAL 1183

  Fly  1256 QIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYV----VSTSFLCWMPLNIPTN 1316
            :..:|.|....:.|:.:|::..||...|.||.:|:...|| ||.|    |:.:|......:|.|
Human  1184 KYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILD-FIVVSGALVAFAFSGSKGKDINT- 1246

  Fly  1317 SAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLA 1381
              .:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.|:..
Human  1247 --IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1309

  Fly  1382 RCNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFE 1446
            .|.|.:.....||.|.::             ..|.......||.| ....|::||:..|:||||.
Human  1310 YCTDESKELERDCRGQYL-------------DYEKEEVEAQPRQW-KKYDFHYDNVLWALLTLFT 1360

  Fly  1447 VLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIANYSE 1497
            |.:.:||..|.    |...:..||          .:.||..::.|    ..:.:||.::|..:.|
Human  1361 VSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPF----FFVNIFVALIIITFQE 1421

  Fly  1498 NKGTALLTVDQRRWCDLKKRLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHIIFKRVIA 1553
             :|..:::.     |.|:|..:.       |:||  ::|......:.:.:|:.::..  |:..|.
Human  1422 -QGDKVMSE-----CSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPP--FEYFIM 1478

  Fly  1554 VVVLINSMLLSITWIKGEVHTE-RLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVT 1617
            .::.:|:::|.:.:.......| .|..::.|.|.:|.:|.|:|.|||....|::...|.:| .||
Human  1479 AMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD-FVT 1542

  Fly  1618 VAGVIWIILQTIL---RNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMF 1679
            |.|.|..||.|.:   .|.::..|..:....|...:..:..|:::|:.|...|.....::...:.
Human  1543 VLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1607

  Fly  1680 LLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYCT 1742
            :|.|.||:.|..:||.:...:  .|.|..||.:.:..:.:|||..|||.|::||..|:.......
Human  1608 MLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDE 1672

  Fly  1743 LGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQN 1807
            ..|   .|:||:..| ..||.:|..:.::::|||.||:||:||.  |...:.::|....:..|..
Human  1673 QAN---ATECGSDFA-YFYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEFIR 1731

  Fly  1808 TWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQKDRLLFKYMCYELDKLHNGEDVTFHDV 1868
            .|...|....|.|....:..:|:.:...|    :|..   |:.:|.: ..::...:.||:|.|..
Human  1732 VWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPA---RVAYKRL-VRMNMPISNEDMTVHFT 1792

  Fly  1869 INMLSYRSVDIRKALQLE-------------EL----------LAREEFEYLV------EEEVAK 1904
            ..:::.    ||.||:::             ||          |.::..:.||      |..|.|
Human  1793 STLMAL----IRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGK 1853

  Fly  1905 MTIRTWLEGCLKKIRAQNASKQQN----------SLIAGLRATNEQPVMRPNI---------QED 1950
            :.....:....|:.:......||.          ||...|:||.||  .:|.:         |:.
Human  1854 VYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQ--TQPAVLRGARVFLRQKS 1916

  Fly  1951 KAPL---GAVDKSAISTISGAVAGACPPTSDA---FSPTFSSTENEE----KDGSSSAVVQLPHS 2005
            ...|   ||:.... |.|..:|:.....|.||   ..|......:.|    :.|:.:..||: .|
Human  1917 STSLSNGGAIQNQE-SGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQM-QS 1979

  Fly  2006 ETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGR-KFLA 2069
            .|.....|....|.     .|.|.....|.:.:..:.|....    .:.||.||.:...| ..|.
Human  1980 ITRRGPDGEPQPGL-----ESQGRAASMPRLAAETQPVTDAS----PMKRSISTLAQRPRGTHLC 2035

  Fly  2070 PTSSD---PQQRSTLSDKERLHITSQQRKKNSMT--------------------TLPHAGQLG-- 2109
            .|:.|   |.|.|:.....|.| ..:.||:.|:.                    ..|..|..|
Human  2036 STTPDRPPPSQASSHHHHHRCH-RRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCR 2099

  Fly  2110 ---QLAKQRGGGGEATKSSSFFAQLNSEIGQFH-------------------YPTINAAAAAAAL 2152
               :..::||...|..:.||    .:||..:|:                   :||...|......
Human  2100 RERERRQERGRSQERRQPSS----SSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP 2160

  Fly  2153 HGYGHGHGHGH-----GGHGGHGGHGEHQM 2177
            |..|.|..:|.     .|....|..|..|:
Human  2161 HPQGSGSVNGSPLLSTSGASTPGRGGRRQL 2190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	59/318 (19%)
		Ion_trans	705..927	CDD:459842	71/261 (27%)
		Ion_trans	1224..1497	CDD:459842	80/293 (27%)
		Ion_trans	1545..1793	CDD:459842	72/253 (28%)
CACNA1B	NP_000709.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		16/31 (52%)
		I	82..359		70/368 (19%)
		Ion_trans	94..367	CDD:459842	68/364 (19%)
		Binding to the beta subunit. /evidence=ECO:0000250	379..396		2/16 (13%)
		II	468..712		65/249 (26%)
		Ion_trans	481..720	CDD:459842	69/244 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..1038		51/230 (22%)
		PRK12678	831..>988	CDD:237171	37/164 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1054..1076		4/21 (19%)
		III	1137..1419		80/305 (26%)
		Ion_trans	1150..1380	CDD:459842	72/249 (29%)
		IV	1456..1711		70/261 (27%)
		Ion_trans	1470..1719	CDD:459842	72/257 (28%)
		GPHH	1728..1781	CDD:465306	10/56 (18%)
		Ca_chan_IQ	1792..1869	CDD:462591	13/80 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1916..1968		11/52 (21%)
		PHA03307	1942..>2338	CDD:223039	54/264 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1981..2206		45/224 (20%)