DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and Cacna1s

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_446325.1 Gene:Cacna1s / 682930 RGDID:70983 Length:1850 Species:Rattus norvegicus


Alignment Length:1983 Identity:442/1983 - (22%)
Similarity:763/1983 - (38%) Gaps:562/1983 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 LLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIV--------PKF 456
            ::|:.|...|:...|.|..:..||:..|...|..:|   ::.:...|.|.:.|:        .|.
  Rat    95 IVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIV---FLGVFTAILEQVNIIQTNTAPMSSKG 156

  Fly   457 SYLSIMRAPRPLIMIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQF 519
            :.|.: :|.|...::|.||  |...:|..::  |.||| :...::::.|..||.:.:|.::|::.
  Rat   157 AGLDV-KALRAFRVLRPLR--LVSGVPSLQVVLNSIFK-AMLPLFHIALLVLFMVIIYAIIGLEL 217

  Fly   520 F-GELKNHCVMNNTEYDLYKRPILTI-NSLAIPDTFCSMDPDSGYQCS-PGMVCMKMDFLSSYVI 581
            | |::...|....|:.      :.|: |....|   |:. ..||..|: .|..|..         
  Rat   218 FKGKMHKTCYFIGTDI------VATVENEKPSP---CAR-TGSGRPCTINGSECRG--------- 263

  Fly   582 GFNG-------FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNV 639
            |:.|       |::...|:.||||..|.|||..::|...|::.......||.|:|...::.:.|:
  Rat   264 GWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328

  Fly   640 FIAVITETFNEIRVQFQQMWGARGHIQKTAASQILSGNDTGW-------RLVTIDDNKHGGLAPE 697
            .:.|::..|.:.|.:.:    :||..||....|.|..:..|:       .::.:||.:.|.|:.:
  Rat   329 VLGVLSGEFTKEREKAK----SRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGKLSLD 389

  Fly   698 ----------------------------------TCHAILRSPYFRMLVMSVILANGIVTATMTF 728
                                              .||.:::|..|..||:.::..|   |.::..
  Rat   390 EGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIVALN---TLSIAS 451

  Fly   729 KHDGRP------RDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTL 787
            :|..:|      :||       ...|...|..:|.|.|:|.||.|.|:....::|:..:.....|
  Rat   452 EHHNQPLWLTHLQDV-------ANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGIL 509

  Fly   788 HIVPM----FYPSGLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTMCLLIISS 845
            .|:.:    ..|.|::..:.:|::||.|.:   ..|...|..:....:.:.||::.....:||.:
  Rat   510 EILLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFA 574

  Fly   846 SISMQLFCFLCDF-------TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTP--LVAV 901
            .:.||||....||       :.|::||:|.:|:||:||.|.|..||...::.......|  ||.:
  Rat   575 LLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCI 639

  Fly   902 YFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQ 966
            |||:..:....|:|::|:|:.:|||...|.:...::.|..|:.         |.::....||..:
  Rat   640 YFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERK---------RRKMSRGLPDKSE 695

  Fly   967 MTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTA 1031
                          :.|.:..|    :||                         |||        
  Rat   696 --------------EERSTMTK----KLE-------------------------QKP-------- 709

  Fly  1032 KVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFG 1096
                                                         |.:|..|.:| .::|:    
  Rat   710 ---------------------------------------------KGEGIPTTAK-LKIDE---- 724

  Fly  1097 SRSIRRSVRSGSIKLKQTYEHLMENGD-------IAAAPRANSGRARPHDLDIKLLQAKRQQAEM 1154
                   ..|...::|..|......||       |.|:||                  .|..||:
  Rat   725 -------FESNVNEVKDPYPSADFPGDDEEDEPEIPASPR------------------PRPLAEL 764

  Fly  1155 RRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFL 1219
            :..::...:.|...|     |:....::.|.:|.:||:|.:                        
  Rat   765 QLKEKAVPIPEASSF-----FIFSPTNKIRVLCHRIVNATW------------------------ 800

  Fly  1220 GLVTYLDWVMIFATTLSCISMMFETP-NYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTP 1283
                :.:::::| ..||..::..|.| ....|.:..|:..:|.|....::|:.||:...|.|...
  Rat   801 ----FTNFILLF-ILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHK 860

  Fly  1284 KAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTL---VPHMRKVVY 1345
            .::.::....||:.:..||   |..|.|.....|..::|.:||.:||||....   :.|:.:.|:
  Rat   861 GSFCRNYFNILDLLVVAVS---LISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 922

  Fly  1346 ELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVGVFMRRVFVTKMKLT 1410
            ...|....|:||:|   ||.|:||..||||:.|:...|||.:....|:|.|.:    ::.|    
  Rat   923 VAIRTIGNIVLVTT---LLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYY----YIYK---- 976

  Fly  1411 PGPDESYPAM--LVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAV-------GP 1466
                :..|..  |.||.|.: ..|:|||:..||::||.|.:|:||   ..:|.||:       ||
  Rat   977 ----DGDPTQIELRPRQWIH-NDFHFDNVLSAMMSLFTVSTFEGW---PQLLYKAIDSNEEDTGP 1033

  Fly  1467 VH------AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKKR-------- 1517
            |:      |::..|||.|.....:.:|||.||..:.|...|      :.:.|:|.|.        
  Rat  1034 VYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGET------EYKNCELDKNQRQCVQYA 1092

  Fly  1518 LKIAQPL--HLPPRPDGRKIRAFTYDITQHI---IFKRVIAVVVLINSMLLSITWIKGEVH---T 1574
            || |:||  ::|..|       :.|.:...:   .|:.::..::::|::.|      |..|   :
  Rat  1093 LK-ARPLRCYIPKNP-------YQYQVWYVVTSSYFEYLMFALIMLNTICL------GMQHYNQS 1143

  Fly  1575 ERLVIVSAVL----TFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIIL---QTILRN 1632
            |::..:|.:|    |.:|.:|:::|.|||.||||:....|.:|.|:.:..:|.:||   .|:|.:
  Rat  1144 EQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLAS 1208

  Fly  1633 D--------------------LSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSF----F 1673
            .                    :|..|..:..::|...:..:...::.|:.|    ..|||    :
  Rat  1209 SGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWT----FIKSFQALPY 1269

  Fly  1674 IIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMV 1736
            :...:.:|.|.||:.|..:||.:...:|  |.|..||.:....|.:|||..|||.|.:|:..|  
  Rat  1270 VALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLAC-- 1332

  Fly  1737 QPPY---CTLGNNY---WETDCG-NFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEED 1794
              .|   |...::|   .|..|| ||  :..||.:||::..::::||.||:||:||.  |...:.
  Rat  1333 --SYGKRCDPESDYAPGEEYACGTNF--AYYYFISFYMLCAFLIINLFVAVIMDNFD--YLTRDW 1391

  Fly  1795 ALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLK----------GRLECDPQKDRLLFKY 1849
            ::|....:..|:..|...|...:|.|....|..:||.::          .|:.|    .||:...
  Rat  1392 SILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVAC----KRLVGMN 1452

  Fly  1850 MCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGC 1914
            |     .|::...|||:..:..|      :|.||:::   ....||...||          |...
  Rat  1453 M-----PLNSDGTVTFNATLFAL------VRTALKIK---TEGNFEQANEE----------LRAI 1493

  Fly  1915 LKKIRAQNASKQQNSLI----------------------------------------------AG 1933
            :|||..:.:.|..:.:|                                              ||
  Rat  1494 IKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTVQIQAG 1558

  Fly  1934 LRATNEQPVMRPNIQE------------DKAPLGAVDKSAISTISGAVAG----------ACPPT 1976
            ||...|:..  |.|..            ::|.:.|..:..|...:|.:.|          :.||.
  Rat  1559 LRTIEEEAA--PEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPV 1621

  Fly  1977 SDAFSP-TFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTA 2040
            .....| .|:..|.||.: |...:...|.:      .|:.....|.....::.:..|    .|:.
  Rat  1622 MANQRPLQFAEMEMEELE-SPVFLEDFPQN------PGTHPLARANTNNANANVAYG----NSSH 1675

  Fly  2041 RHVMTVGKRGYALNRSDSTGSSAGRK--FLAPTS-SDPQQRSTLSDKERLHITSQQRKKNSMTTL 2102
            |:........|.....:..|....|:  |..|.| |....||.:...||   ...||:.......
  Rat  1676 RNSPVFSSIRYERELLEEAGRPVTREGPFSQPCSVSGVNSRSHVDKLER---QMSQRRMPKGQVP 1737

  Fly  2103 PHAGQLGQ---LAKQRGGG-----GEATKSSSF 2127
            |...||.|   ...:.|.|     .|.:.|.||
  Rat  1738 PSPCQLSQEKHPVHEEGKGPRSWSTETSDSESF 1770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 66/273 (24%)
Ion_trans 734..927 CDD:278921 59/214 (28%)
Ion_trans 1240..1497 CDD:278921 83/275 (30%)
Ion_trans 1571..1793 CDD:278921 74/264 (28%)
Cacna1sNP_446325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 64/267 (24%)
Ion_trans 50..345 CDD:306908 66/275 (24%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 3/16 (19%)
II. /evidence=ECO:0000305 418..664 67/255 (26%)
Ion_trans 431..672 CDD:306908 68/250 (27%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..717 14/148 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..758 8/44 (18%)
III. /evidence=ECO:0000305 786..1068 91/332 (27%)
Ion_trans 798..1075 CDD:306908 89/333 (27%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 32/98 (33%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 1/2 (50%)
IV. /evidence=ECO:0000305 1105..1384 77/301 (26%)
Ion_trans 1117..1392 CDD:306908 78/292 (27%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 21/69 (30%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 18/45 (40%)
GPHH 1393..1463 CDD:318993 16/78 (21%)
Ca_chan_IQ 1465..1536 CDD:312334 14/89 (16%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 0/19 (0%)
CAC1F_C 1558..1838 CDD:318975 48/229 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1697..1779 21/77 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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