Protein Alignment na and Scn7a

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: NP_001375437.1
• Gene: Scn7a / 64155
• RGDID: 61922
• Length: 1680
• Species: Rattus norvegicus
• Alignment Length: 1823
• Identity: 386/1823 - (21%)
• Similarity: 699/1823 - (38%)
• Gaps: 435/1823 - (23%)

  Fly   335 LADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSL-----NTPKTFERYPSLQFITFAS 394
            |....|..||..:     |.|:.|..|.||..|:|:.:.|:     |.|:..          .|.
  Rat    98 LCTLSPLSSLRRA-----VIKVLVHPLFRLLILISVLTDSILMCMSNLPEWI----------LAV 147

  Fly   395 DTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYL 459
            :..:..::|.|::.|:..||:..|...:|.|.|          .|:...:.:||::......|.|
  Rat   148 ENTLLGIYTFEILVKVIARGIWAGSFSFLGDLW----------NWLDFSVTLFELITRSSPLSSL 202

  Fly   460 SIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELK 524
            .:.:..|.|.:::.:.:..........:.|..|:....| .:.||||...||:| :|: |.|.||
  Rat   203 PMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAI-ALALFFLTVSSLFG-MGL-FMGNLK 264

  Fly   525 NHC----------VMNN---TEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFL 576
            :.|          ||.|   ::|.:.:|........|.....|....|:|. |..|.:|:|..
  Rat   265 HKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGL-CPEGYMCVKEG-- 326

  Fly   577 SSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFI 641
            |:...||..|::...::..:::..:|: :..::|..|..........:|..:.|:.|:.:.::|:
  Rat   327 SNPDNGFTSFDNFGWALLAMFRLMTQD-YPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFL 390

  Fly   642 AVIT----------------------ETFNEIRVQFQ--QMWGARGHIQKTAASQILSGNDTGWR 682
            .::|                      :|..|...:.:  :|...:..::|.:.:.|   |.|
  Rat   391 GILTMAYEQEKQRASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIEMKKRSPTSI---NTT--- 449

  Fly   683 LVTIDDNKHGGL-APET-------------------------------CHAILRSPYFRMLVMSV 715
            |..::|...|.. .|||                               ...|:..|.|.:.::..
  Rat   450 LDILEDTALGHKEEPETSRKECPLCWYKFTKTCFIWKCSPCWIKLNEFADRIITHPLFDLFLVIC 514

  Fly   716 ILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKF--- 777
            |:.|   ...:..:|.....::. .......|||..:..:|.:.||..:...||::.|.|.|
  Rat   515 IILN---ICFLALEHFPMSEELM-SLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWHIFDSI 575

  Fly   778 -------ELLLA---AGTTLHIVPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLG 831
                   |:|||   ..|...:||:.:            ::|.|.:|..:..: :|.|.. ..|.
  Rat   576 LVVLGLTEMLLADIEEITVFILVPLIF------------IKLGKYAPPFKNLM-RILGRALVALK 627

  Fly   832 SLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF--ESFPEAFMSMFQILTQEAWVEV 883
            .|::.....:..|:...|:||        |.:   |...::  ..|..|::::|:||..| |:|.
  Rat   628 DLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIET 691

  Fly   884 MDETM-IRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQS-AE 946
            :.|.| :.......|    ::::..|...|::|.||||::......|...:..|:.|..:.: |.
  Rat   692 LWECMEVAGEAWCIP----FYMMVILIGNLLILYLFVALVSSFASYDATTEVSKEAKNLQLAVAW 752

  Fly   947 IKETLP-FRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSE 1010
            ||..:. ..|:|..|     :.|:.....:....|.|:|:...|.:.||....:.:
  Rat   753 IKMVINCVLLKILCK-----EKTVSTEATDQTCDPSVKENISGHTLSELSNTQTFL--------- 803

  Fly  1011 CWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGG 1075
                                 :.:...|...|..:|    :|.:|.|:...|....|....|...
  Rat   804 ---------------------RYKDQSSGTEKTPVT----ESESQSLIASPSVSETVPIASGESD 843

  Fly  1076 LKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDL 1140
            :::           :|.|:..|:|...|.:.   |:||:........|||.:
  Rat   844 IEN-----------LDNKETRSKSANGSSKE---KMKQSSSSECSTVDIAIS------------- 881

  Fly  1141 DIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESR-------FRKICQKIVHARYDAR 1198
                     ::.||.....:..|.:|.....:....|.||||       .||.|.|||...:
  Rat   882 ---------EEEEMVYEHEKSKLHKNGYERKSSAGQVSRESRNGKIWRNIRKTCCKIVENSW--- 934

  Fly  1199 LKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQI-AEYGF 1262
                            ...|:||||.|           |...:.....| :....|::| .|||.
  Rat   935 ----------------FECFIGLVTLL-----------CTGTLALEDIY-IDQRKTIKIFLEYGD 971

  Fly  1263 VIF---MSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMI 1324
            :||   ..||:.||.:|.|.    |||..:....||..:.:|    || :.|...|......|..
  Rat   972 MIFAYIFILEMLLKWVAYGF----KAYFSNNWYKLDFMVVIV----LC-LSLIGKTREDLNPLAS 1027

  Fly  1325 LRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLM--FIFASYGVQLYGGRLARCNDPT 1387
            ::.:|.||:.:....|:.|:..|.:  ..:..||..|:.||  .:|:..||.|:.|:...|.|||
  Rat  1028 IKFLRALRVLSQFERMKVVLRALIK--TTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPT 1090

  Fly  1388 ---------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLT 1443
                     :..:..|..:    ||          :||.|       |.| .:.||||:|:..|:
  Rat  1091 RGERFSVFEVMNKSQCENL----VF----------NESMP-------WEN-AKLNFDNVGNGFLS 1133

  Fly  1444 LFEVLSFKGWLDVRDVLIKAVGPV------HAVYIH----IYIFLGCMIGLTLFVGVVIANYSEN 1498
            ||:|.:|.||:.:.:..|.:||..      |:::::    |::..|..:.|.:.:||:|.|:::.
  Rat  1134 LFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQ 1198

  Fly  1499 K-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLI 1558
            |     ....:||.|::.....|:|..|.......|| ..|.:.|..|:..|.:|..:|.:::..
  Rat  1199 KIKQGGSNIFITVKQKKQYRALKKLLYADSQKPAARP-RNKFQGFICDVVTHRVFNVIIILLICF 1262

  Fly  1559 NSMLLSITWIKGEVHTERLVI-VSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVI 1622
            .:..:.|...:.....|..|. ::::.|.:|.:|.::|..||... |:.|..|.:|.:|.|..:.
  Rat  1263 QATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKLTAFRCH-YFTSAWNVHDFMVVVFSIT 1326

  Fly  1623 WIILQTILRNDLSYF----------FGFMVVILRFFTITGK-----HTTLKMLMLTVGVSVCKSF 1672
            .::|...:.   .||          ...::.:||    .||     |..:..|||::...:..:.
  Rat  1327 GLLLPLSIG---QYFVPPSLVQLLLLSRIIHVLR----PGKGPKVFHDLMLPLMLSLPALLNIAL 1384

  Fly  1673 FIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ 1737
            .|    ||::|.||:.|...|..||...||...:||.:..:.:..||::.|...|:.::.
  Rat  1385 LI----FLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLD----- 1440

  Fly  1738 PPYCTLGNNYWET--------------DCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLF 1788
                .:.|:.|..              |||:.:..:.||.::.:|...|::|:.|.:|||..|:
  Rat  1441 ----AIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVVLIMEFLSI- 1500

  Fly  1789 YSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVK-FILRLLKGRLECDPQKDRLLFKYMCY 1852
            .|..::..||..|.|.|...||..|..:...|...::. |...|........|.|.:|:
  Rat  1501 PSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALDPPLFMAKPNKGQLV------ 1559

  Fly  1853 ELD-KLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLV-----------------E 1899
            .:| .:..|:.:...|:  :|::....:.|..::|::|:..|..:::                 :
  Rat  1560 AMDLPMAAGDRIHCLDI--LLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRK 1622

  Fly  1900 EEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIA---GLRATNEQPVMRPNIQEDKAPLGAVDKSA 1961
            :|....||   ::...|..|.:.:.|:...:..   |....|.:.|....|:|         |::
  Rat  1623 QEAVSATI---IQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSKGVHSGQIEE---------KAS 1675

  Fly  1962 IST 1964
            |.|
  Rat  1676 IQT 1678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	68/332 (20%)
		Ion_trans	705..927	CDD:459842	54/249 (22%)
		Ion_trans	1224..1497	CDD:459842	78/297 (26%)
		Ion_trans	1545..1793	CDD:459842	63/277 (23%)
Scn7a	NP_001375437.1	I. /evidence=ECO:0000250|UniProtKB:Q01118	100..401		72/332 (22%)
		Ion_trans	117..405	CDD:459842	66/314 (21%)
		II. /evidence=ECO:0000250|UniProtKB:Q01118	487..756		61/290 (21%)
		Ion_trans	504..738	CDD:459842	55/255 (22%)
		Na_trans_assoc	742..926	CDD:461936	45/258 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..874		17/84 (20%)
		III. /evidence=ECO:0000250|UniProtKB:Q01118	915..1223		94/371 (25%)
		Ion_trans	932..1203	CDD:459842	84/334 (25%)
		Na_channel_gate	1194..1245	CDD:240441	12/51 (24%)
		IV. /evidence=ECO:0000250|UniProtKB:Q01118	1232..1530		76/320 (24%)
		Ion_trans	1249..1496	CDD:459842	59/267 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1646..1680		8/42 (19%)