DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and SCN10A

DIOPT Version :9

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	XP_005265428.1	Gene:	SCN10A / 6336	HGNCID:	10582	Length:	1959	Species:	Homo sapiens

Alignment Length:	2069	Identity:	446/2069 - (21%)
Similarity:	747/2069 - (36%)	Gaps:	581/2069 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GEPFLADYGPEES-------LNESADI---EWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYP 385
            ||| |.|..|..|       ||:...|   .....||   |.....|:..|::.::.    ..||
Human    76 GEP-LEDLDPFYSTHRTFMVLNKGRTISRFSATRALW---LFSPFNLIRRTAIKVSV----HSYP 132

  Fly   386 SLQFITFASDTAV-------------------TLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFD 431
             |.|..|.:.|.:                   |:::|.|.:.|:..||....|..||:|.|...|
Human   133 -LWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLD 196

  Fly   432 ASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQ 496
            .|:::..::...:.    |..:.......::||.:.:.:|..|:|.:...:          .|.:
Human   197 FSVITLAYVGTAID----LRGISGLRTFRVLRALKTVSVIPGLKVIVGALI----------HSVK 247

  Fly   497 QIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNN------TEYDLYKRPILTINSLAIPD-TF 553
            ::.:||:..:|.:|::.|:|:|.| |.|||.||.|:      |.|..:::|.:.||.....| ..
Human   248 KLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLL 312

  Fly   554 CSMDPDSGYQCSPGMVCMKM----DFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAID 614
            |....|||: |..|.:|:|.    ||      .:..|:..|.:..::::..:|:.|..:..:.:
Human   313 CGNGSDSGH-CPDGYICLKTSDNPDF------NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTL- 369

  Fly   615 SLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVIT--------ETFNEIRVQFQQMWGARGHIQ 666
                 |.:     .:|..:||..::.:.|:.:||:|        .|.:||..:.::...|...::
Human   370 -----RTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLR 429

  Fly   667 KTAASQILSGNDT---------------------------------------------------- 679
            |........|.||
Human   430 KEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLG 494

  Fly   680 ---GWRL---------------------VTID--------------------------------- 687
               |.|.                     ||.|
Human   495 LASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQ 559

  Fly   688 ----DNKHG----------GLAP------------------------------------------ 696
                |::||          .|||
Human   560 PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVL 624

  Fly   697 -------ETCHAILRS---------------------------PYFRMLVMSVILANGIVTATMT 727
                   :.|...|.|                           |:..:.:...|:.|   |..|.
Human   625 EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVN---TIFMA 686

  Fly   728 FKHDGRPRDVFYERYYYI-ELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLH--I 789
            .:|.|  ....:|....| .:|||.....|.:|||.......|::...:.|:.::...:.|.  :
Human   687 MEHHG--MSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGV 749

  Fly   790 VPMFYPSGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF- 852
            ......|.|..|::|||.:|.|:.|.|...: ||.|.. ..||:|.|....::.:.:.:..||.
Human   750 AKKGSLSVLRSFRLLRVFKLAKSWPTLNTLI-KIIGNSVGALGNLTIILAIIVFVFALVGKQLLG 813

  Fly   853 -------------------CFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPL 898
                               ..:.||  |.|    |:.:|:||..| |:|.|...|....|:   :
Human   814 ENYRNNRKNISAPHEDWPRWHMHDF--FHS----FLIVFRILCGE-WIENMWACMEVGQKS---I 868

  Fly   899 VAVYFILYHLFVTLIVLSLFVAVIL-----DNLELDEDIKKLKQLKFREQSAEI-----KETLPF 953
            ..:.|:...:...|:||:||:|::|     |||...||..::..|:......::     |:.|
Human   869 CLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQAL-- 931

  Fly   954 RLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVF 1018
             ...|.:....||             ||..    ...|::|....|..||
Human   932 -CSFFSRSCPFPQ-------------PKAE----PELVVKLPLSSSKAEN--------------- 963

  Fly  1019 RKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVV--------GTKGGGG 1075
                  .|...||:..:.|           :......|....|....|.|        |......
Human   964 ------HIAANTARGSSGG-----------LQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDD 1011

  Fly  1076 LKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDL 1140
            |:..|        ..|.:.|....|.:..:....::::..:||        .||:........||
Human  1012 LEDDG--------GEDAQSFQQEVIPKGQQEQLQQVERCGDHL--------TPRSPGTGTSSEDL 1060

  Fly  1141 ---------DIKLLQAKRQQAEMRRNQR---------EEDLRENHPFFDTPLFLVPRESRFRKIC 1187
                     |..:.|...:..:...:..         ||.||:.....|.   |...:..|.:.|
Human  1061 APSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADD---LEEPDDCFTEGC 1122

  Fly  1188 QKIVH---ARYDARLKDP--LTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNY 1247
              |.|   .:.|. .|.|  :..:.||..|:.:.:     ::.:..:||...||..|:.||  :|
Human  1123 --IRHCPCCKLDT-TKSPWDVGWQVRKTCYRIVEH-----SWFESFIIFMILLSSGSLAFE--DY 1177

  Fly  1248 RVMDHPTLQ-IAEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCW 1308
            .:...||:: :.||.   |......|:.||.:|.|.    |.|..:....||..|..:|...|..
Human  1178 YLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNISLISLTA 1238

  Fly  1309 MPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGV 1373
            ..|.....:..:.|..||.:||||..:....||.||..|......|:.|..:.::...||:..||
Human  1239 KILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGV 1303

  Fly  1374 QLYGGRLARCNDPT-----------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWA 1427
            .|:.|:..||.:.|           ::.:.||           |::.:.|   |:       .|.
Human  1304 NLFAGKFWRCINYTDGEFSLVPLSIVNNKSDC-----------KIQNSTG---SF-------FWV 1347

  Fly  1428 NPRRFNFDNIGDAMLTLFEVLSFKGWLDV-------RDVLIKAVGPVHAVYIHIY----IFLGCM 1481
            |. :.||||:....|.|.:|.:||||:|:       |:|.::.....: ||:::|    |..|..
Human  1348 NV-KVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDN-VYMYLYFVIFIIFGGF 1410

  Fly  1482 IGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYD 1541
            ..|.|||||:|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ..|.:.|.:|
Human  1411 FTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKFQGFVFD 1474

  Fly  1542 ITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYW 1605
            |.....|...|.|::.:|.:.:.: |..:.|..|:.|..::.....||..|.|||..|.. :.|:
Human  1475 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYF 1538

  Fly  1606 QSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTI----------TGKHTTLKML 1660
            .:..|.:|.:|.|..:..:|...||::..|||...:..::|...|          .|..|.|..|
Human  1539 TNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFAL 1603

  Fly  1661 MLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGE 1725
            |:    |:...|.|...:||::|.|::.|...|..|::..||....||.:....:..||:|.|..
Human  1604 MM----SLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSA 1664

  Fly  1726 DWNKIMHDCM-VQPPYC--TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFS 1786
            .|:.::...: ..||||  .|.| |....|||:....:|:|.|:.:|...|::|:.:|:|:|||:
Human  1665 GWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFN 1729

  Fly  1787 LFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMC 1851
            : .:.|....||..|...|..||...|......|....:......|.|.|.. |:.:|.:...|.
Human  1730 V-ATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRI-PKPNRNILIQMD 1792

  Fly  1852 YEL---DKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLVEE------EVAKMTI 1907
            ..|   ||:| ..|:.|....|:|.       ::.:|:.|.|..|.:::...      |....|:
Human  1793 LPLVPGDKIH-CLDILFAFTKNVLG-------ESGELDSLKANMEEKFMATNLSKSSYEPIATTL 1849

  Fly  1908 RTWLEGCLKKIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPL---GAV-----------D 1958
            | |.:..:.....|.|  .::.::....|.:..|.: |..:|:.|.|   |.|           |
Human  1850 R-WKQEDISATVIQKA--YRSYVLHRSMALSNTPCV-PRAEEEAASLPDEGFVAFTANENCVLPD 1910

  Fly  1959 KSAISTISGAVAGACPPTSDAFS---------PTFSSTENEEKDGSSSAVVQLP 2003
            ||     ..|.|.:.||:.::.:         .|.||.:||::..|...:...|
Human  1911 KS-----ETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP 1959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	72/324 (22%)
		Ion_trans	734..927	CDD:278921	55/221 (25%)
		Ion_trans	1240..1497	CDD:278921	78/282 (28%)
		Ion_trans	1571..1793	CDD:278921	68/235 (29%)
SCN10A	XP_005265428.1	Ion_trans	150..410	CDD:278921	63/286 (22%)
		Na_trans_cytopl	466..>537	CDD:288761	5/70 (7%)
		Ion_trans	685..897	CDD:278921	56/224 (25%)
		Na_trans_assoc	907..1150	CDD:284034	50/316 (16%)
		Ion_trans	1172..1430	CDD:278921	79/286 (28%)
		Na_channel_gate	1422..1474	CDD:240441	12/52 (23%)
		Ion_trans	1496..1735	CDD:278921	69/244 (28%)
		GPHH	1745..1802	CDD:293510	14/57 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920