DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and SCN5A

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001092874.1 Gene:SCN5A / 6331 HGNCID:10593 Length:2016 Species:Homo sapiens


Alignment Length:2159 Identity:438/2159 - (20%)
Similarity:749/2159 - (34%) Gaps:719/2159 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GEPFLADYGPEES-------LNESADI---EWVNKLWV-------RR------------LMRLCA 366
            ||| |.|..|..|       ||:...|   ...|.|:|       ||            ::.:|.
Human    77 GEP-LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCT 140

  Fly   367 -LVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQF 430
             |.:...::.:.|..:.:|....|         |.::|.|.:.|:..||.......:|:|.|...
Human   141 ILTNCVFMAQHDPPPWTKYVEYTF---------TAIYTFESLVKILARGFCLHAFTFLRDPWNWL 196

  Fly   431 DASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMP--KSRINQIFKR 493
            |.|::...::|..:          |...||.:|..|.|..::.:.|     :|  |:.:..:. :
Human   197 DFSVIIMAYVSENI----------KLGNLSALRTFRVLRALKTISV-----IPGLKTIVGALI-Q 245

  Fly   494 SSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMNNT-----------------EYDLYKRP 540
            |.:::.:|.:..:|.:|::.|:|:| |.|.|::.||.|.|                 ..|||   
Human   246 SVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLY--- 307

  Fly   541 ILTINSLAIPDTF-----------CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIF 594
                  |:.|:.:           |....|:| .|..|..|:|......:  |:..|:..|.:..
Human   308 ------LSDPENYLLKNGTSDVLLCGNSSDAG-TCPEGYRCLKAGENPDH--GYTSFDSFAWAFL 363

  Fly   595 TVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVITETF------ 648
            .:::..:|:.|..:..:.:      |:|     .:|..:||..::.:.|:.:||:...:      
Human   364 ALFRLMTQDCWERLYQQTL------RSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA 422

  Fly   649 -----NEIRVQFQQMWGARGHIQKTAASQILSGNDTGWR-------------------------- 682
                 .|...:||:   |...::|...:..:.|.||..|                          
Human   423 TIAETEEKEKRFQE---AMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSS 484

  Fly   683 --------------------------------------------LVTI-------------DDNK 690
                                                        :.|.             |:|.
Human   485 GTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENS 549

  Fly   691 HGGLAPETCHAILRSPY---------------------FRMLVMSVILANGIVT--------ATM 726
            ..| ..|:.|..|..|:                     ......|.:..||:|:        ||.
Human   550 TAG-ESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATS 613

  Fly   727 TFKH-------------------DGRPR---------DVFYE----------------------- 740
            ...|                   .|.|:         |.|.|                       
Human   614 PGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEE 678

  Fly   741 --------------RYYYIE--------------------------------------------- 746
                          ||...|                                             
Human   679 SRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTS 743

  Fly   747 ----------LVFTCLLDLETLFKIYCLGWRGYYKHSIHKFE--LLLAAGTTLHIVPMFYPSGLT 799
                      ||||.:...|..|||..|....|::...:.|:  :::.:...|.:..|...|.|.
Human   744 EFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLR 808

  Fly   800 YFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF----------- 852
            .|::|||.:|.|:.|.|...: ||.|.. ..||:|.:....::.|.:.:.||||           
Human   809 SFRLLRVFKLAKSWPTLNTLI-KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSD 872

  Fly   853 ------CFLCDFTKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVT 911
                  ..:.||.      .||:.:|:||..| |:|.|.:.|..:.::|..||   |:|..:...
Human   873 SGLLPRWHMMDFF------HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLV---FLLVMVIGN 927

  Fly   912 LIVLSLFVAVIL-----DNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILH 971
            |:||:||:|::|     |||...::.:::..|:.  ..|.|:..|.|                :.
Human   928 LVVLNLFLALLLSSFSADNLTAPDEDREMNNLQL--ALARIQRGLRF----------------VK 974

  Fly   972 RIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036
            |...||....:|:                                  |.|||       |.:.|.
Human   975 RTTWDFCCGLLRQ----------------------------------RPQKP-------AALAAQ 998

  Fly  1037 GSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRV----------D 1091
            |.....:|..:.......:::...........|.:.|     |||....:|..|          |
Human   999 GQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPG-----QGTPGDPEPVCVPIAVAESDTDD 1058

  Fly  1092 QKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHD---------LDIKLLQA 1147
            |::....|:.....|.    ||     .|:..::..|.|      |.|         ......:|
Human  1059 QEEDEENSLGTEEESS----KQ-----QESQPVSGGPEA------PPDSRTWSQVSATASSEAEA 1108

  Fly  1148 KRQQAEMRRNQREEDLRENHPFFDTP-LFLVPRES----------RFRKICQKIVHARYDARLKD 1201
            ...||:.|:..:.|.        ..| ....|.:|          ...::.::|.....|  :||
Human  1109 SASQADWRQQWKAEP--------QAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQD--VKD 1163

  Fly  1202 P---------------------LTGKE----RKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMM 1241
            |                     ..||.    ||..|..:.:     ::.:..:||...||..::.
Human  1164 PEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEH-----SWFETFIIFMILLSSGALA 1223

  Fly  1242 FETPNYRVMDHPTLQI-AEYG---FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVS 1302
            ||  :..:.:..|::: .||.   |.....||:.||.:|.|.    |.|..:....||..|..||
Human  1224 FE--DIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVS 1282

  Fly  1303 TSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFI 1367
            ...|....|........:.|..||.:||||..:....||.||..|......|:.|..:.::...|
Human  1283 LVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 1347

  Fly  1368 FASYGVQLYGGRLARCNDPT----------ISRREDCVGVFMR-RVFVTKMKLTPGPDESYPAML 1421
            |:..||.|:.|:..||.:.|          ::.:..|..:.:. .::.||:|:            
Human  1348 FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKV------------ 1400

  Fly  1422 VPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVGPVHA----------VYIHIYI 1476
                       ||||:|...|.|.:|.:||||:|:....:.:.|....          :|..|:|
Human  1401 -----------NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFI 1454

  Fly  1477 FLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIR 1536
            ..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|...:|....||| ..|.:
Human  1455 IFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-LNKYQ 1518

  Fly  1537 AFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAV-LTFV--FVVEVVMKNIA 1598
            .|.:||.....|...|..::.:|.:.:.:.  ..:...|::.|::.: |.||  |..|.::| :|
Human  1519 GFIFDIVTKQAFDVTIMFLICLNMVTMMVE--TDDQSPEKINILAKINLLFVAIFTGECIVK-LA 1580

  Fly  1599 FTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGKHTT 1656
            .....|:.:..|.:|.:|.:..::..:|..|::   .|||.   |.|:.|    |...:......
Human  1581 ALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQ---KYFFSPTLFRVIRLARIGRILRLIRGAKG 1642

  Fly  1657 LKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRI 1721
            ::.|:..:.:|:...|.|...:||::|.|::.|...|..||:..||....||.:....:..||:|
Human  1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQI 1707

  Fly  1722 VTGEDWNKIMHDCM-VQPPYC--TLGN-NYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIM 1782
            .|...|:.::...: ..||||  ||.| |....|||:....:::|.|:.:|...||:|:.:|||:
Human  1708 TTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIIL 1772

  Fly  1783 ENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVI--------------PVRRVK------- 1826
            ||||: .:.|....||..|...|...|...|......|              |:|..|       
Human  1773 ENFSV-ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLI 1836

  Fly  1827 --------------------FILRLLKGRLECDPQKDRLLFKYMCYELDKLHNGEDVTF-----H 1866
                                |..|:|....|.|..|.::..|:|.....|: :.|.:|.     |
Human  1837 NMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKI-SYEPITTTLRRKH 1900

  Fly  1867 DVINML----SYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQ 1927
            :.::.:    ::|...::::|:....|.|::....:.||.|...     ||.:..:.::|.|:  
Human  1901 EEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPER-----EGLIAYVMSENFSR-- 1958

  Fly  1928 NSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEK 1992
                                     |||....|:||:.|      .||:.|  |.|.::::|.:.
Human  1959 -------------------------PLGPPSSSSISSTS------FPPSYD--SVTRATSDNLQV 1990

  Fly  1993 DGSSSAVVQLPHSE 2006
            .||..:     |||
Human  1991 RGSDYS-----HSE 1999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 64/327 (20%)
Ion_trans 734..927 CDD:278921 67/318 (21%)
Ion_trans 1240..1497 CDD:278921 73/281 (26%)
Ion_trans 1571..1793 CDD:278921 67/235 (29%)
SCN5ANP_001092874.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..56
I. /evidence=ECO:0000305 113..420 68/349 (19%)
Ion_trans 151..423 CDD:278921 63/314 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..591 8/130 (6%)
Na_trans_cytopl 485..578 CDD:288761 8/93 (9%)
II. /evidence=ECO:0000305 699..969 64/282 (23%)
Ion_trans 734..927 CDD:278921 51/203 (25%)
Na_trans_assoc 953..1200 CDD:284034 52/335 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1005..1141 27/163 (17%)
III. /evidence=ECO:0000305 1187..1501 86/347 (25%)
Ion_trans 1222..1479 CDD:278921 74/285 (26%)
Na_channel_gate 1471..1523 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1510..1807 84/304 (28%)
Ion_trans 1545..1782 CDD:278921 67/243 (28%)
GPHH 1792..1849 CDD:293510 7/56 (13%)
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 1839..1901 11/62 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1959..2016 18/54 (33%)
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 1974..1977 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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