back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment na and SCN2A

DIOPT Version :10

Sequence 1:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster
Sequence 2:	NP_066287.2	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens

Alignment Length:	2165	Identity:	434/2165 - (20%)
Similarity:	755/2165 - (34%)	Gaps:	726/2165 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 LKGGE--PFLADYG--PEESLN---ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERY- 384
            |:.|:  ||:  ||  |.|.::   |..|..::||              .|.:.||..|...|:
Human    56 LEAGKSLPFI--YGDIPPEMVSVPLEDLDPYYINK--------------KTFIVLNKGKAISRFS 104

  Fly   385 --PSLQ----------------------------------FITFAS--------DTAVTLLFTAE 405
              |:|.                                  |:|.::        :...|.::|.|
Human   105 ATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFE 169

  Fly   406 MIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM 470
            .:.|:..||....:..:|:|.|...|.::::|.:::             :|..|..:.|.|...:
Human   170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-------------EFVDLGNVSALRTFRV 221

  Fly   471 IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVM---NN 531
            :|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:|.|:.   :|
Human   222 LRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDN 285

  Fly   532 TEYDL----------------YKRPILTIN-SLAIPD-------------TFCSMDPDSGYQCSP 566
            :.:::                :.|.:...| ...|.|             ..|....|:| ||..
Human   286 SSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG-QCPE 349

  Fly   567 GMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFS 626
            |.:|:|.....:|  |:..|:..:.:..::::..:|:.|..:....:      |||     .:|.
Human   350 GYICVKAGRNPNY--GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL------RAAGKTYMIFFV 406

  Fly   627 TMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQMW--------------------- 659
            .:||..::.:.|:.:||:...:.|           ...:||||.
Human   407 LVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAES 471

  Fly   660 ----GARG----HIQKTAASQILSGND-------------------------------------- 678
                ||.|    ....:.||::.|.::
Human   472 RDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKG 536

  Fly   679 -----TGWRLV----------------------------------------------------TI 686
                 .|.||.                                                    |.
Human   537 FRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTF 601

  Fly   687 DDN----------------KH-------------------------------------------- 691
            :||                :|
Human   602 EDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSA 666

  Fly   692 GGLAPE--------------TCHA---ILRSPYFRMLVMSVILANGIVTATMTFKHDGRPR---- 735
            |.|.||              :.|.   :|..|..|...||:.   .|:|.||....:.|.:
Human   667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIA---SILTNTMEELEESRQKCPPC 728

  Fly   736 -----------------------------DVF-----------------YERYYYIE-------- 746
                                         |.|                 .|.|...|
Human   729 WYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSV 793

  Fly   747 --LVFTCLLDLETLFKIYCL--------GWRGY--YKHSIHKFELLLAAGTTLHIVPMFYPSGLT 799
              ||||.:...|...||..:        ||..:  :..|:...||.||....|.:        |.
Human   794 GNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSV--------LR 850

  Fly   800 YFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL 855
            .|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||        |.:
Human   851 SFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914

  Fly   856 ---CDFTKF--ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVL 915
               |:..::  ..|..:|:.:|::|..| |:|.|.:.|....:|:...|   |::..:...|:||
Human   915 SNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTV---FMMVMVIGNLVVL 975

  Fly   916 SLFVAVIL-----DNLELDEDIKKLKQLKF---REQSAEIKETLPFRLRIFEKFPDSPQMTILHR 972
            :||:|::|     |||...:|..::..|:.   |.|..
Human   976 NLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKG--------------------------- 1013

  Fly   973 IPNDFMLPKVRESFMKHFVIELETEDSL--VENCKRPMSECWESNVVFRKQKPVRIM---NKTAK 1032
              .||:..|:||...|.||.:.:..|.:  :|:.......|..::......|.:..:   |.|..
Human  1014 --IDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTS 1076

  Fly  1033 VRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGS 1097
              ..|||:.|    :::::|:....:...|..:.|....|....::..|           ::|.|
Human  1077 --GIGSSVEK----YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-----------EEFSS 1124

  Fly  1098 RSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREED 1162
            .|   .:.....||..|........||.|                   .|:.:|.|:   :.||.
Human  1125 ES---DMEESKEKLNATSSSEGSTVDIGA-------------------PAEGEQPEV---EPEES 1164

  Fly  1163 LRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSL-HNFLGLVTYLD 1226
            |.....|.:..:       |..|.||..:...     |..|....||..||.: ||      :.:
Human  1165 LEPEACFTEDCV-------RKFKCCQISIEEG-----KGKLWWNLRKTCYKIVEHN------WFE 1211

  Fly  1227 WVMIFATTLSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYI 1287
            ..::|...||..::.||  :..:....|    |:.|:..|.....||:.||.:|.|.    :.|.
Human  1212 TFIVFMILLSSGALAFE--DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYF 1270

  Fly  1288 KDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFK 1352
            .:....||..|..||...|....|......|.:.|..||.:||||..:....||.||..|.....
Human  1271 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIP 1335

  Fly  1353 EILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVFVTKMK 1408
            .|:.|..:.::...||:..||.|:.|:...|.:.|         ::...:|..:.
Human  1336 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALI---------- 1390

  Fly  1409 LTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDV-------RDVLIKAVGP 1466
                 :.:..|.     |.|. :.||||:|...|:|.:|.:||||:|:       |:|.::   |
Human  1391 -----ESNQTAR-----WKNV-KVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ---P 1441

  Fly  1467 VHA------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKI 1520
            .:.      :|..|:|..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|..
Human  1442 KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506

  Fly  1521 AQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVL 1584
            .:|....||| ..|.:...:|.....:|...|.:::.:|.:.:.: |..:.:..|..|..::.|.
Human  1507 KKPQKPIPRP-ANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVF 1570

  Fly  1585 TFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FM 1641
            ..:|..|.|:|.|:.  |.|     |    |.:|.:|.:..::.:.|..::.   .||..   |.
Human  1571 IVLFTGECVLKLISL--RYYYFTIGW----NIFDFVVVILSIVGMFLAELIE---KYFVSPTLFR 1626

  Fly  1642 VVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGI 1702
            |:.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..||...||
Human  1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGI 1691

  Fly  1703 GRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ-PPYCTLGNNY----WETDCGNFTASLIYF 1762
            ....||.:....:..||:|.|...|:.::...:.. ||.|....::    .:.||||.:..:.:|
Human  1692 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFF 1756

  Fly  1763 CTFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNIVDIHQRGVI------ 1820
            .::.:|...:|:|:.:|:|:||||:  :.||.| .||..|...|...|...|......|
Human  1757 VSYIIISFLVVVNMYIAVILENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819

  Fly  1821 ----------------PVRRVKFILRLLKG-RLEC-DPQKDRLLFKYM------CYELDKLH--- 1858
                            .|:.:...|.::.| |:.| |     :||.:.      ..|:|.|.
Human  1820 DFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD-----ILFAFTKRVLGESGEMDALRIQM 1879

  Fly  1859 -------NGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEF-EYLVEEEVAKMTIRTWLEGCL 1915
                   |...|::..:...|.      ||..::..::.:..: .||::::|.|::      ...
Human  1880 EERFMASNPSKVSYEPITTTLK------RKQEEVSAIIIQRAYRRYLLKQKVKKVS------SIY 1932

  Fly  1916 KKIRAQNASK---QQNSLIAGL--RATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPP 1975
            ||.:.:....   ::::||..|  .:|.|:..|.|                 ||.|       ||
Human  1933 KKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTP-----------------STTS-------PP 1973

  Fly  1976 TSDAFSPTFSSTENEEKDGS 1995
            :.|  |.|....|..|||.|
Human  1974 SYD--SVTKPEKEKFEKDKS 1991

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.