DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and SCN1A

DIOPT Version :10

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001159435.1 Gene:SCN1A / 6323 HGNCID:10585 Length:2009 Species:Homo sapiens


Alignment Length:2149 Identity:422/2149 - (19%)
Similarity:768/2149 - (35%) Gaps:683/2149 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 LKGGE--PFLADYG--PEESLN---ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERYP 385
            |:.|:  ||:  ||  |.|.::   |..|..::||              .|.:.||..|...|:.
Human    55 LEAGKNLPFI--YGDIPPEMVSEPLEDLDPYYINK--------------KTFIVLNKGKAIFRFS 103

  Fly   386 SLQ-------------------------------------FITFAS--------DTAVTLLFTAE 405
            :..                                     |:|.::        :...|.::|.|
Human   104 ATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFE 168

  Fly   406 MIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM 470
            .:.|:..||....:..:|:|.|...|.::::|.:::             :|..|..:.|.|...:
Human   169 SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT-------------EFVDLGNVSALRTFRV 220

  Fly   471 IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVM----- 529
            :|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:|.|:.     
Human   221 LRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTN 284

  Fly   530 -NNTEYDLYKRPILTINSLAIPDT--------------------------FCSMDPDSGYQCSPG 567
             :..|:.:.|...:..|...|.:|                          .|....|:| ||..|
Human   285 ASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAG-QCPEG 348

  Fly   568 MVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFST 627
            .:|:|.....:|  |:..|:..:.:..::::..:|:.|..:....:      |||     .:|..
Human   349 YMCVKAGRNPNY--GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL------RAAGKTYMIFFVL 405

  Fly   628 MIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQM----------------WGARGHI 665
            :||..::.:.|:.:||:...:.|           ...:||||                ..|..|.
Human   406 VIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHS 470

  Fly   666 QKTAASQILSGNDT--------------------------------------------------- 679
            ::.:|:..||.:.:                                                   
Human   471 REPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535

  Fly   680 ----GWRLV----------------------------------------------------TIDD 688
                |.||.                                                    |.:|
Human   536 FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED 600

  Fly   689 N-----------KHGGLAPETCHAILRSPYFRMLVM--------SVILANGIVT----------- 723
            |           :||...........||.  |||.:        |.:..||:|:           
Human   601 NESRRDSLFVPRRHGERRNSNLSQTSRSS--RMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSP 663

  Fly   724 -----------------------------------ATMTFKHDGRPR------------------ 735
                                               .:|.|..|...|                  
Human   664 VGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELE 728

  Fly   736 --------------DVFY----ERYY--------------YIELVFTCLLDLETLF--------- 759
                          ::|.    ..|:              :::|..|..:.|.|||         
Human   729 ESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMT 793

  Fly   760 ------------------------KIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYP----- 795
                                    ||..:....|::...:.|:..:   .||.:|.:...     
Human   794 DHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI---VTLSLVELGLANVEGL 855

  Fly   796 SGLTYFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF------- 852
            |.|..|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||       
Human   856 SVLRSFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDC 919

  Fly   853 -CFL---CDFTKF--ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVT 911
             |.:   |...::  ..|..:|:.:|::|..| |:|.|.:.|....:.:...|   |::..:...
Human   920 VCKIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTV---FMMVMVIGN 980

  Fly   912 LIVLSLFVAVIL-----DNLELDEDIKKLKQL-----KFREQSAEIKETLPFRLRIFEKFPDSPQ 966
            |:||:||:|::|     |||...:|..::..|     :..:..|.:|.      :|:|       
Human   981 LVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKR------KIYE------- 1032

  Fly   967 MTILHRIPNDFMLPKVRESFMKHFVI--ELETEDSLVENCKRPMSECWESNV--VFRKQKPVRIM 1027
                          .:::||::...|  |::..|.|  |.|:  ..|..::.  :.:....::.:
Human  1033 --------------FIQQSFIRKQKILDEIKPLDDL--NNKK--DSCMSNHTAEIGKDLDYLKDV 1079

  Fly  1028 NKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQ 1092
            |.|......|||:.|    :||::|:....:...|..:.|....|....::..|           
Human  1080 NGTTSGIGTGSSVEK----YIIDESDYMSFINNPSLTVTVPIAVGESDFENLNT----------- 1129

  Fly  1093 KKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRN 1157
            :.|.|.|          .|:::.|.|.|:        ::|......|:...:             
Human  1130 EDFSSES----------DLEESKEKLNES--------SSSSEGSTVDIGAPV------------- 1163

  Fly  1158 QREEDLRENHPFFDTPLFLVPRE-------SRFRKICQKIVHARYDARLKDPLTGKE----RKVQ 1211
                   |..|..:....|.|..       .|| |.||..|.   :.|      ||:    |:..
Human  1164 -------EEQPVVEPEETLEPEACFTEGCVQRF-KCCQINVE---EGR------GKQWWNLRRTC 1211

  Fly  1212 YKSL-HNFLGLVTYLDWVMIFATTLSCISMMFET--PNYRVMDHPTLQIAEYGFVIFMSLELALK 1273
            ::.: ||      :.:..::|...||..::.||.  .:.|......|:.|:..|.....||:.||
Human  1212 FRIVEHN------WFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLK 1270

  Fly  1274 ILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVP 1338
            .:|.|.    :.|..:....||..|..||...|....|......|.:.|..||.:||||..:...
Human  1271 WVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFE 1331

  Fly  1339 HMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDC 1394
            .||.||..|......|:.|..:.::...||:..||.|:.|:...|.:.|         ::...||
Human  1332 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDC 1396

  Fly  1395 VGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDV--- 1456
            :.:..|.....                    |.|. :.||||:|...|:|.:|.:||||:|:   
Human  1397 LKLIERNETAR--------------------WKNV-KVNFDNVGFGYLSLLQVATFKGWMDIMYA 1440

  Fly  1457 ----RDVLIKAVGPVH--AVYIHIY----IFLGCMIGLTLFVGVVIANYSENK-----GTALLTV 1506
                |:|.::   |.:  ::|:::|    |..|....|.||:||:|.|:::.|     ....:|.
Human  1441 AVDSRNVELQ---PKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1502

  Fly  1507 DQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKG 1570
            :|:::.:..|:|...:|....||| |.|.:...:|.....:|...|.:::.:|.:.:.: |..:.
Human  1503 EQKKYYNAMKKLGSKKPQKPIPRP-GNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQS 1566

  Fly  1571 EVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTIL 1630
            |..|..|..::.|...:|..|.|:|.|:.  |.|     |    |.:|.:|.:..::.:.|..::
Human  1567 EYVTTILSRINLVFIVLFTGECVLKLISL--RHYYFTIGW----NIFDFVVVILSIVGMFLAELI 1625

  Fly  1631 RNDLSYFFG---FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALA 1688
            .   .||..   |.|:.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.
Human  1626 E---KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIF 1687

  Fly  1689 GTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM-VQPPYC-----TLGNNY 1747
            |...|..||...||....||.:....:..||:|.|...|:.::...: .:||.|     ..|::.
Human  1688 GMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSV 1752

  Fly  1748 WETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNI 1811
             :.||||.:..:.:|.::.:|...:|:|:.:|:|:||||:  :.||.| .||..|...|...|..
Human  1753 -KGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV--ATEESAEPLSEDDFEMFYEVWEK 1814

  Fly  1812 VDIHQRGVIPVRRVKFILRLLKGRLECDPQKDRLLFKYMCYEL---DKLHNGEDVTFHDVINMLS 1873
            .|......:...::......|:..|.. ||.::|....|...:   |::| ..|:.|.....:|.
Human  1815 FDPDATQFMEFEKLSQFAAALEPPLNL-PQPNKLQLIAMDLPMVSGDRIH-CLDILFAFTKRVLG 1877

  Fly  1874 YRSVDIRKALQLEELL-----AREEFEYLV------EEEVAKMTI-RTWLEGCLKK-IRAQNASK 1925
            .........:|:||..     ::..::.:.      :|||:.:.| |.:....||: ::..:.:.
Human  1878 ESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTY 1942

  Fly  1926 QQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSDAFS-PTFSSTEN 1989
            .:|.:..|.....::.::...|.|:     ::.:....|:|.|   ||||:.|..: |.....|.
Human  1943 NKNKIKGGANLLIKEDMIIDRINEN-----SITEKTDLTMSTA---ACPPSYDRVTKPIVEKHEQ 1999

  Fly  1990 EEKD 1993
            |.||
Human  2000 EGKD 2003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 361..654 CDD:459842 65/386 (17%)
Ion_trans 705..927 CDD:459842 70/382 (18%)
Ion_trans 1224..1497 CDD:459842 78/296 (26%)
Ion_trans 1545..1793 CDD:459842 66/266 (25%)
SCN1ANP_001159435.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 2/4 (50%)
I. /evidence=ECO:0000305 110..454 64/366 (17%)
Ion_trans 127..433 CDD:459842 60/328 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..529 5/73 (7%)
Na_trans_cytopl 555..718 CDD:463401 18/164 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 5/42 (12%)
II. /evidence=ECO:0000305 750..1022 60/279 (22%)
Ion_trans 767..980 CDD:459842 47/220 (21%)
Na_trans_assoc 1006..1213 CDD:461936 50/300 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 10/62 (16%)
III. /evidence=ECO:0000305 1200..1514 88/353 (25%)
Ion_trans 1217..1492 CDD:459842 81/308 (26%)
Na_channel_gate 1484..1536 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1523..1821 81/310 (26%)
Ion_trans 1540..1796 CDD:459842 67/267 (25%)
S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1561..1571 2/9 (22%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8 1619..1636 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1986..2009 6/18 (33%)

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