Protein Alignment na and scn8aa

DIOPT Version :10

• Sequence 1: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Sequence 2: XP_068072894.1
• Gene: scn8aa / 58152
• ZFINID: ZDB-GENE-000828-1
• Length: 1960
• Species: Danio rerio
• Alignment Length: 1879
• Identity: 372/1879 - (19%)
• Similarity: 652/1879 - (34%)
• Gaps: 631/1879 - (33%)

  Fly   371 TSVSLNTPKTFERY---PSLQ----------------------------------FITFAS---- 394
            |.|.||..||..|:   |:|.                                  |:||::
Zfish    93 TFVVLNKGKTIFRFSATPALYMISPFNLARRIAIKILIHSVFSMFIMCTILTNCVFMTFSNPPEW 157

  Fly   395 ----DTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPK 455
                :...|.::|.|...|:..||.......:|:|.|...|..::|..:::             :
Zfish   158 SKQVEYTFTGIYTFESAVKIIARGFCIDGFTFLRDPWNWLDFMVISMAYVT-------------E 209

  Fly   456 FSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-F 519
            |..|..:.|.|...::|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |
Zfish   210 FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLF 273

  Fly   520 FGELKNHCV---MNNTE------------YDLYKRPILT-INSLAIPD----TFCSMDPDSGYQC 564
            .|.|:..||   :|.||            :|.|   ||. .|...:||    ..|....||| :|
Zfish   274 MGNLRQKCVIWPINITEMFPDVNGSRAFNWDEY---ILNETNFYFLPDQLDALLCGNSSDSG-RC 334

  Fly   565 SPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FY 624
            ..|..|||.....:|  |:..|:....:...:::..:|:.|..:....:      |||     .:
Zfish   335 PEGYTCMKAGRNPNY--GYTSFDSFGWAFLALFRLMTQDFWENLYQLTL------RAAGKTYMIF 391

  Fly   625 FSTMIFFLAWLVKNVFIAVITETFN---------------EIRVQFQQM---------------- 658
            |..:||..::.:.|:.:||:...:.               |.:...:|:
Zfish   392 FVLVIFVGSFYLVNLILAVVAMAYEEQNQATMEEAERKEAEFKAMLEQLKKQQEDAQANAMATSA 456

  Fly   659 ------------------------------------------W---------------------- 659
                                                      |
Zfish   457 GTVSEDVVEDDGDGEGNLSCSSSEMSKLSSKSAKERRNRKKKWRQKEQDKEKGDSEKFVKSESDD 521

  Fly   660 -------------GARGHI---------------QKTAASQILS-----GNDT------------ 679
                         |.|..|               ::.:.|.|.|     |::.
Zfish   522 GSRRRFRFPDNRLGRRSSIMNQSLLSIPGSPFPSRRNSKSSIFSRCKDGGSENEFADDEHSTVEE 586

  Fly   680 ---------------------GWRLVTIDDN---------KHGGLAPET---------------- 698
                                 |.|..|:|.|         ..|.|.||.
Zfish   587 YDERRDSFLSPQRRSSYTGFYGKRNSTVDCNGVVSLIGPGPGGRLLPEVIIDKAATDDSPTTDLE 651

  Fly   699 ---------------------------------------------------------------C- 699
                                                                           |
Zfish   652 IKKKLSGSLMVSVEQLNTSFGRKERANSVMSALTNTLVEELEESQRKCPPCWYKFANTFLIWECG 716

  Fly   700 ----------HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI-ELVFTCLL 753
                      :.|:..|:..:.:...|:.|   |..|..:|  .|....:|....: .||||.:.
Zfish   717 PLWMSIKEIVNLIVMDPFVDLAITICIVLN---TLFMAMEH--YPMTPQFEHVLSVGNLVFTGIF 776

  Fly   754 DLETLFKIYCL--------GWRGY--YKHSIHKFELLLAAGTTLHIVPMFYPSGLTYFQVLRVVR 808
            ..|...|:..:        ||..:  :..|:...||.||....|.:        |..|::|||.:
Zfish   777 TAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSV--------LRSFRLLRVFK 833

  Fly   809 LIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL---CDFTKF 861
            |.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||        |.:   |:..::
Zfish   834 LAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAQDCELPRW 897

  Fly   862 --ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL- 923
              ..|..:|:.:|::|..| |:|.|.:.|....:.:..:|   |::..:...|:||:||:|::|
Zfish   898 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIV---FMMVMVIGNLVVLNLFLALLLS 958

  Fly   924 ----DNLELDEDIKKLKQLKFRE---------QSAEIKETLPFRLRIFEKFPDSPQMTILHRIPN 975
                |||...:|..::..|:...         ..|:::|.:  .:.:..|..|..:       |.
Zfish   959 SFSADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRELV--NIILGRKVTDEAK-------PL 1014

  Fly   976 DFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSL 1040
            |.|..:.......|..:::..:                  :.::|       |........|||:
Zfish  1015 DDMYDRKLNCIANHTGVDISRD------------------LDYQK-------NGNGTTSGIGSSV 1054

  Fly  1041 RKLAITHIINDS-----NNQRLMLGDSAMLPV-VGTKGGGGLKSQGTITHSKPWRVDQKKFGSRS 1099
            .|    ::|:|.     :|..|    :..:|: ||......|.::              .|.|
Zfish  1055 GK----YMIDDDHMSFIHNPNL----TVCVPIAVGESDFENLNTE--------------DFSS-- 1095

  Fly  1100 IRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLR 1164
              .|...||.:|          .||:::..:.        :|||        .|:......|.:.
Zfish  1096 --ESEAEGSKEL----------DDISSSEGST--------IDIK--------PEVEEAVVVETVE 1132

  Fly  1165 ENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLT---GKE----RKVQYKSL-HNFLGL 1221
            |          .|..|:.:.:.|    .|||.. ...|:|   ||.    ||..|..: ||
Zfish  1133 E----------YVDPEACWTEAC----IARYKC-CDVPITEGWGKNWWFLRKTCYLIVEHN---- 1178

  Fly  1222 VTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQ-IAEYGFVIF---MSLELALKILADGLFFT 1282
              :.:.::||...||..::.||  :..:....|:: |.||..::|   ..||:.||.:|.|..
Zfish  1179 --WFETLIIFMILLSSGALAFE--DVYIEQRKTIRIILEYADMVFTYIFILEMLLKWVAYGFV-- 1237

  Fly  1283 PKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYEL 1347
              .|..:....||.||..||...|....|........:.|..||.:||||..:....||.||..|
Zfish  1238 --KYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1300

  Fly  1348 CRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVF 1403
            ......|:.|..:.::...||:..||.::.|:...|.:.|         ::.:.:|..:.
Zfish  1301 VGAIPSIMNVLLVCLIFWLIFSIMGVNMFAGKYYYCYNETEKAYFELDVVNNKSECFALI----- 1360

  Fly  1404 VTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG--- 1465
                      :::|..:.    |.|. :.||||:|...|.|.:|.:||||:   |::..||.
Zfish  1361 ----------EQNYTEVR----WKNV-KINFDNVGAGYLALLQVATFKGWM---DIMYAAVDSRR 1407

  Fly  1466 ----PVHA--VYIHIY----IFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLK 1515
                |.:.  :|::||    |..|....|.||:||:|.|:::.|     ....:|.:|:::.:..
Zfish  1408 VEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM 1472

  Fly  1516 KRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIV 1580
            |:|...:|....|||. .|::...:|.....:|...|.:::.:|.:.:.:........||.::.
Zfish  1473 KKLGSKKPQKPIPRPQ-NKLQGMVFDFVTQQVFDISIMILICLNMVTMMVETDDQSQETENILY- 1535

  Fly  1581 SAVLTFVFVV----EVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG-- 1639
              .:.|:|:|    |.|:|..|.. ..|:.:..|.:|.:|.:..::.:.|..::.   .||..
Zfish  1536 --WINFIFIVAFTSEFVLKLFALR-HYYFTNGWNIFDCVVVILSIVGMFLADLIE---KYFVSPT 1594

  Fly  1640 -FMVVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYG 1699
             |.|:.|    |...:......::.|:..:.:|:...|.|...:||::|.:::.|...|..||..
Zfish  1595 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKRE 1659

  Fly  1700 EGIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYC----------TLGNNYWETDCGN 1754
            .||....||.:....:..||.|.|...|:.::...:..||.|          ..||      |||
Zfish  1660 SGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCEPTKENPGTSVKGN------CGN 1718

  Fly  1755 FTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVD 1813
            .:..:.:|..:.::...||:|:.:|||:||||:......|.|.. .|..:|...|...|
Zfish  1719 PSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESADPLCE-DDFESFYEIWEKFD 1776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
na	NP_001096981.2	Ion_trans	361..654	CDD:459842	76/368 (21%)
		Ion_trans	705..927	CDD:459842	64/251 (25%)
		Ion_trans	1224..1497	CDD:459842	79/298 (27%)
		Ion_trans	1545..1793	CDD:459842	62/268 (23%)
scn8aa	XP_068072894.1	Ion_trans	131..423	CDD:459842	66/317 (21%)
		ARGLU	<416..>448	CDD:405931	2/31 (6%)
		Na_trans_cytopl	544..682	CDD:463401	13/137 (9%)
		Ion_trans	732..945	CDD:459842	55/230 (24%)
		Na_trans_assoc	971..1172	CDD:461936	49/301 (16%)
		Ion_trans	1177..1453	CDD:459842	82/310 (26%)
		Na_channel_gate	1445..1497	CDD:240441	11/52 (21%)
		Ion_trans	1502..1756	CDD:459842	62/266 (23%)