DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1sa

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_005168332.1 Gene:cacna1sa / 570683 ZFINID:ZDB-GENE-090514-1 Length:1778 Species:Danio rerio


Alignment Length:2024 Identity:440/2024 - (21%)
Similarity:786/2024 - (38%) Gaps:522/2024 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 LGRKQSLK-------GGEP-------FLADYGP--EESLNESADIEWVNKLWVRRLMRLCALVSL 370
            |.|||..|       ||.|       ||....|  :..:|   .:|| ....:..|:.:.|....
Zfish    19 LKRKQREKLKKLQATGGNPRPARSLLFLTLKNPFRKACIN---IVEW-KPFEIIILLTIFANCVA 79

  Fly   371 TSVSLNTPK-----TFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQF 430
            .:|.:..|:     |.....||::|       ..::||.|...|:...|.|.....||::.|...
Zfish    80 LAVFMPMPEEDTNNTNSNLESLEYI-------FLIIFTMECFLKIVAYGFLFHADAYLRNCWNIL 137

  Fly   431 DASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAP---------RPLIMIRFLR-VFLKFSMPKS 485
            |       ::.:.:.:|.|  :|...:.:|.:.||         :.|...|.|| :.|...:|..
Zfish   138 D-------FVIVTMGLFTV--VVDFINSISGVEAPVEQKGGFDMKALRAFRVLRPLRLVSGVPSL 193

  Fly   486 RI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFFGELKNHCVMNNTEYDLYKRPILT-INSL 547
            ::  :.|.| |...:::::|...|.:::|.::|::.|     .|.|:.|.|......|.| .::.
Zfish   194 QVVMSSILK-SMLPLFHISLLVFFMVTIYAIIGLELF-----KCKMHKTCYHTGTDIIATGDDAQ 252

  Fly   548 AIPDTFCSMDPDSGYQCS-PGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYR 611
            |.|   |: ...:|.:|: .|..| :.|:.... .|...|:::..|:.||||..:.:||..::|.
Zfish   253 AAP---CA-QAGNGRRCTLNGTEC-RGDWPGPN-NGITHFDNLGFSMLTVYQCITTQGWTDVLYW 311

  Fly   612 AIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNE---------------IRVQFQQMWGA 661
            ..|::.......||.|:|...::.:.|:.:.|:...|.:               .|.||.:  ..
Zfish   312 VNDAIGMEWPWLYFVTLILLGSFFILNLVLGVLCGEFTKEREKSSRSGEYQILRERQQFDE--DL 374

  Fly   662 RGHIQKTAASQILSGNDTGWRLVTIDDNKHGGLAPET---------------------------C 699
            :|:::....::::..:..|..|:.:.|    |...||                           |
Zfish   375 KGYMEWITQAEVMDNDQEGQGLLPLQD----GSETETLYELDILNKLMFYVRHARRWNRFFRRKC 435

  Fly   700 HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDV--FYERYYYIELVFTCLLDLETLFKIY 762
            ...::|..|..||:.::..|.:..||   :|..:|..:  |.:.   .......|..:|...|:|
Zfish   436 RVWVKSKLFYWLVILLVFFNTLAIAT---EHHQQPDSLTNFQDN---TNKALLSLFAVEMFLKMY 494

  Fly   763 CLGWRGYYKHSIHKFELLLAAGTTLHIV----PMFYPSGLTYFQVLRVVRLIKAS---PMLEGFV 820
            .:|...|:....::|:..:.:...|.::    .:....|::..:.:|::|:||.:   ..|...|
Zfish   495 AMGLPSYFMSLFNRFDCFVVSVGILELILVRMDVMSVMGISVLRCIRLLRIIKITRHWTTLSNLV 559

  Fly   821 YKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLCDF-------TKFESFPEAFMSMFQILTQE 878
            ..:....:.:.||::.....::|.:.:.||:|....:|       :.|::||:|.:::|||||.|
Zfish   560 ASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDDRVRRSNFDNFPQALITVFQILTGE 624

  Fly   879 AWVEVMDETMIRTSKTLTP--LVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFR 941
            .|..||.:.::.......|  ||::|||:..:....|:|::|:|:.:|||...|.:...::.|..
Zfish   625 GWNYVMYDGIMAHGGPAIPGILVSIYFIILFICGNYILLNVFLAIAVDNLAEAESLTSAQKEKAE 689

  Fly   942 EQSAEIKETLPFRLRIF-EKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCK 1005
            |:.         |.|:. |..||..                             |.|.:|     
Zfish   690 EKK---------RKRLLRENLPDKG-----------------------------EEEKAL----- 711

  Fly  1006 RPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGT 1070
                                :..|.|:.||                                   
Zfish   712 --------------------LAKKLAEQRA----------------------------------- 721

  Fly  1071 KGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRA 1135
                  |..|..|.:| .:||:           ..|...::|..:           .|....|..
Zfish   722 ------KIDGIPTTAK-LKVDE-----------FESNVNEIKDPF-----------PPADFPGDD 757

  Fly  1136 RPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLK 1200
            ...:.:|.|....|..|:::..:.|..:.|...|     ||...:::|||:|.:|::|       
Zfish   758 EEEEPEIPLSPRPRPMADLQLKETEVPMPEASAF-----FLFGPQNKFRKLCHRIINA------- 810

  Fly  1201 DPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP----NYRVMDHPTLQIAEYG 1261
                                 .|:.:.:::| ..||.||:..|.|    ::|   :..|..|:|.
Zfish   811 ---------------------TTFTNIILLF-ILLSSISLAAEDPIDPMSFR---NQVLAYADYV 850

  Fly  1262 FVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILR 1326
            |....:.|:.||:...|.|....::.::....||:.:..||   |..|.:.....|..::|.:||
Zfish   851 FTSVFTAEIVLKMTTYGAFLHKGSFCRNSFNILDLIVVGVS---LLSMGMESSAISVVKILRVLR 912

  Fly  1327 CVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRR 1391
            .:||||.......::.||..:....|.|..:..:.:||.|:||..||||:.|:...|.||.....
Zfish   913 VLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKFLYCTDPLKMTA 977

  Fly  1392 EDCVGVFMRRVFVTKMKLTPGPDESYPAMLV-PRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLD 1455
            |:|.|.|::.           .:.:...|:| .|:|.| ...||||:.:.||.||.|.:|:||  
Zfish   978 EECQGTFIQH-----------QENALHDMVVSQRLWMN-SDLNFDNVLNGMLALFTVSTFEGW-- 1028

  Fly  1456 VRDVLIKAV-------GPVH------AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVD 1507
             .|:|.||:       |||:      :::..:|:.|.....:.:|||.||..:.| :|.     .
Zfish  1029 -PDLLYKAIDSNLENMGPVYNNHIEISIFFIVYLILIAFFMMNIFVGFVIVTFQE-QGE-----Q 1086

  Fly  1508 QRRWCDLKKR--------LKIAQPL--HLPPRPDGRKIRAFTYD---ITQHIIFKRVIAVVVLIN 1559
            :.:.|:|.|.        || |:||  ::|..|       :.|.   |.....|:.::.:::::|
Zfish  1087 EYKNCELDKNQRQCVQYALK-ARPLRCYIPKNP-------YQYQVWYIVTSCYFEYLMFLLIMLN 1143

  Fly  1560 SMLLSITWIKGEVH-TERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIW 1623
            :|.|.:...|...| |:....::.:.|.:|.||:::|..||..:||:....|.:|.::.|..::.
Zfish  1144 TMCLGMQHCKQSDHITDLADTLNVIFTVLFTVEMILKLGAFKAKGYFGDPWNVFDFVIVVGSIVD 1208

  Fly  1624 IILQTI-----LRNDLSYFFGF--------------MVVILRFFTITGKHTTLKMLMLTVGV--- 1666
            :||..|     .:..|....|.              |.|.:..|.:......:|:|....|:   
Zfish  1209 VILSEIDAALAAQGGLYCLTGCSEVNPMQAIADSENMSVSITLFRLFRVMRLVKLLNRFEGIRNL 1273

  Fly  1667 --SVCKSF----FIIFGMFLLVFFYALAGTILFGTVKYGEG--IGRRANFGSPVTGVAMLFRIVT 1723
              :..|||    ::...:.:|.|.||:.|..:||.:...:|  |.|..||.:....|.:|||..|
Zfish  1274 LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALLDGTIINRNNNFQTFPQAVLLLFRCAT 1338

  Fly  1724 GEDWNKIMHDCMVQPPY---CTLGNNYW---ETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIM 1782
            ||.|::||..|:    |   |...:.|.   |..||:..| ::||.:||::..::::||.||:||
Zfish  1339 GEGWHEIMLGCL----YGQRCDPKSEYLPGEEYTCGSGFA-ILYFMSFYMLCAFLIINLFVAVIM 1398

  Fly  1783 ENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLK----------GRLE 1837
            :||.  |...:.::|....:..|:..|...|....|.|....|..:||.::          .|:.
Zfish  1399 DNFD--YLTRDWSILGPQHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHRVA 1461

  Fly  1838 CDPQKDRLLFKYMCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFEYLV---- 1898
            |    .||:...|     .|::...|||:..:..|....:.|:.....|:  |.||...::    
Zfish  1462 C----KRLISMNM-----PLNSDGTVTFNATLFALVRTGLKIKTEGNFEQ--ANEELRAIIKKIW 1515

  Fly  1899 ----------------EEEV------AKMTIRTWLEGCLKK------IRAQNASKQQNSLIAGLR 1935
                            ::||      |...|:......:|:      .|....:|....:.||||
Zfish  1516 KRTSMKLLDQVIPALGDDEVTVGKFYATFLIQDHFRKFMKRQEEYYGYRPSKKNKNTTEIQAGLR 1580

  Fly  1936 ATNEQPVMRPNIQ--------EDKAPLGAVDKSAISTISGAVAGACPPTSDAFSPTFSSTENEEK 1992
            :..|:..  |.:|        .|:....|:::|...:|.....|......|.||       .|..
Zfish  1581 SIEEEAA--PELQRAISGDLLNDEEMDRAMEESGEESIYRRAGGLFGNHVDPFS-------MERG 1636

  Fly  1993 DGSSSAVVQLP---------HSETSIAGTGSSATGAAT--------------ATGTSSGLGVGPP 2034
            .|::....|.|         .:||:.|...::......              |..::|.|.....
Zfish  1637 TGAAQVTSQRPLQLADSRADRTETTYASYHANNNNTNNNNRRRHSRCEPHFPACISASRLHSPAS 1701

  Fly  2035 TVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKKNSM 2099
            ..:...:.|:|.|  |.....||       .:|::.|.|:.        ...||:..|:.::.|.
Zfish  1702 AAEFLIQQVLTSG--GLESLASD-------WRFVSVTKSEM--------AAALHLDLQELERKSA 1749

  Fly  2100 TTL-PHAGQ 2107
            ..| .|.||
Zfish  1750 AILNQHKGQ 1758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 69/314 (22%)
Ion_trans 734..927 CDD:278921 49/210 (23%)
Ion_trans 1240..1497 CDD:278921 78/274 (28%)
Ion_trans 1571..1793 CDD:278921 71/258 (28%)
cacna1saXP_005168332.1 Ion_trans 80..356 CDD:278921 68/303 (22%)
Ion_trans 459..682 CDD:278921 54/228 (24%)
Ion_trans 828..1087 CDD:278921 80/285 (28%)
Ion_trans 1147..1409 CDD:278921 73/268 (27%)
GPHH 1417..1480 CDD:293510 15/71 (21%)
Ca_chan_IQ 1482..1553 CDD:285917 10/72 (14%)
CAC1F_C <1686..1754 CDD:293490 17/84 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.950

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