DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1ab

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_021335317.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2336 Species:Danio rerio


Alignment Length:2338 Identity:496/2338 - (21%)
Similarity:854/2338 - (36%) Gaps:605/2338 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   260 GGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGR 324
            ||||||.:..||.|..|...||...|.......::....:.||....|:.       .|.:.:.|
Zfish    13 GGGGGGGSGQGGPGRGGSRQGGPPGAQRMYKQSMAQRARTMAIYNPIPVR-------QNCLTVNR 70

  Fly   325 KQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTS---VSLNTPKTFERYPS 386
            ...|...:..:..|.  :.:.|....||   :.:..::..|.:::|..   |...||.: ||...
Zfish    71 SLFLFSEDNIVRKYA--KKITEWPPFEW---MILTTIIANCIVLALEQHLPVGDKTPLS-ERLEE 129

  Fly   387 LQ--FITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV 449
            .:  ||.         :|..|...|:...|....:..||::.|...|..:|   ...|:..:...
Zfish   130 TEPYFIA---------IFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVV---LTGILSSVGSE 182

  Fly   450 LEIVPKFSYLSIMRAPRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSL 511
            |::    ..|..:|..|||.:   |..|:|.|| |:.|:.|..:      || .|.||....|  
Zfish   183 LDL----RTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMIPLL------QI-GVLLFVAILM-- 233

  Fly   512 YGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDF 575
            :.::|::|: |:....| .|....::|........:....:|.|     .||...|.        
Zfish   234 FAIIGLEFYMGKFHTTC-FNTITGEMYDERPCGARTCDANNTQC-----QGYWLGPN-------- 284

  Fly   576 LSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSL-PAWRAAFYFSTMI---FFLAWLV 636
                 .|...|:::..::.||:|..:.|||..::|.:.|:| .||...:|...:|   ||:..||
Zfish   285 -----YGITQFDNVLFAVLTVFQCITMEGWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLV 344

  Fly   637 KNVFIAVITE---------TFNEIRVQFQQMWGARGHIQKTA-ASQIL---SGNDTG-WRLVTID 687
            ..|......:         .|.:::.|.|......|:::... |.:::   ..|||| .|..|:.
Zfish   345 LGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILAEDDNDTGSRRRPTLK 409

  Fly   688 DNKHGGLAPE-------------------------------------TCHAILRSPYFRMLVMSV 715
            .||...|.|:                                     ....::::..|...|:|:
Zfish   410 KNKADLLNPQEGVDHMGDSVGSPFARGSMSGKGDETPFSKKERRLRFLIRKMVKTQAFYWTVISL 474

  Fly   716 ILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELL 780
            :..|.:..|.:   |..:| ::..:..||.|.:|..|...|.|.|:|.||.|.|:..|.:.|:..
Zfish   475 VALNTLCVAVV---HYDQP-ELLSDFLYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCA 535

  Fly   781 LAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTM 838
            :..|:...:| .|..|.   |::..:.||::|:.|.:   ..|...|..:....|.:.||:....
Zfish   536 VIVGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLF 600

  Fly   839 CLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVM----------DET 887
            ..:::.:.:.||||....:|      |.|::||.|.|::|||||.|.|..||          |:.
Zfish   601 LFIVVFALLGMQLFGGQFNFELGTPPTNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKG 665

  Fly   888 MIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQ-----------LKFR 941
            ||         .:|:||:..||....:|::|:|:.:|||...:::.|.:|           |:..
Zfish   666 MI---------FSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEATTQKMALQKA 721

  Fly   942 EQSAEIKETLPFRLRIFEKFPDS---------PQMTILHRIPNDFMLPKVRESFMKHFVIELETE 997
            ::.||:.......|.|..|....         .|.|...|..|   |...||:...    ||:.|
Zfish   722 KEVAEVSPLSAANLSIAAKEQQKNSKGSKSVWEQRTSEIRRQN---LMTSREALYN----ELDAE 779

  Fly   998 DSLVENCKRPMSECWESNVVFRKQKPVRI--------------MNKTAKVRAAGSSLRKLAIT-- 1046
            |.            |:.|  :|.:..|:.              .|.|.|.|....:.::.:..  
Zfish   780 DH------------WKMN--YRNRPDVKTHLDRPLVVNPQENRNNNTNKPRPDDPNPQERSEEHP 830

  Fly  1047 ---------------HIINDSNNQRLMLGDSA----MLPVVG----------------------- 1069
                           |..:.|:.|.|.|.:.|    ...|.|                       
Zfish   831 SRSHHHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEGAGEHRRPRHHQHRRRDEDGGERG 895

  Fly  1070 -----------TKGG----GGLKSQGTITHSKPWRVD----------QKKFGSRSIRRSVRSGSI 1109
                       |.||    |..|.|....|:.....|          .||.||.|..|.::.|..
Zfish   896 RKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGSLSTARPIQPGLP 960

  Fly  1110 KLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQA--KRQQAEMRRNQREEDLRENHPFFDT 1172
            ..:..|...::|       ..||.:...||.|..|...  ..:||....|.|..||.      |:
Zfish   961 HTESQYSEDLDN-------LRNSSKMAIHDPDPDLYDPYYDPEQANNLLNLRGPDLH------DS 1012

  Fly  1173 PLFLVPRESRFRKICQKIVHARYD---------ARLK-------DPLTGKERKVQ---------- 1211
            .|.|..        ..|:.|...|         |:|:       :|....|:|.:          
Zfish  1013 SLILTD--------SSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKEEEEDDGGDEEG 1069

  Fly  1212 ------------------YKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMD-HPTLQI 1257
                              ::...:::..:.|.:..::....:|.|::..|.|..:..: :..|:.
Zfish  1070 HKRIPPFSSCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIALAAEDPVSQDSERNKVLRY 1134

  Fly  1258 AEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNSA---- 1318
            .:|.|....:.|:.:|::..||.....:|.:|:...|| |: |||.:.:.:...:....|.    
Zfish  1135 FDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLD-FV-VVSGALVAFAFTSFSGGSGKGKD 1197

  Fly  1319 ---AQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRL 1380
               .:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||...|||:.||.
Zfish  1198 ISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRF 1262

  Fly  1381 ARCNDPTISRREDCVG---VFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAML 1442
            ..|.|.:.....||.|   |:.|...|...|               |.| ....|::||:..|:|
Zfish  1263 FYCTDESKEFARDCRGEYLVYERDNEVKSQK---------------REW-KKYDFHYDNVLWALL 1311

  Fly  1443 TLFEVLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGLTLFVGVVIA 1493
            |||.|.:.:||.||.    |...:..||          .:.||..::.|    ..:.:||.::|.
Zfish  1312 TLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVALIII 1372

  Fly  1494 NYSENKGTAL----LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAFTYDITQHII---FK 1549
            .:.|.....:    |..::|...|....   |:||  |:|     :..::|.|.:.|.::   |:
Zfish  1373 TFQEQGDKMMEDYSLEKNERACIDFAIN---AKPLTRHMP-----QNKQSFQYRMWQFVVSPPFE 1429

  Fly  1550 RVIAVVVLINSMLLSITWI-KGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYD 1613
            ..|..::.:|:::|.:.:. ..:.:.:.|..::.|.|..|.:|.::|.|||..|.:::...|.:|
Zfish  1430 YSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNFFRDAWNIFD 1494

  Fly  1614 LLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGM 1678
            .:..:..:..|::..::.|.::..|..:....|...:..:..|:::|:.|...|.....::...:
Zfish  1495 FVSVIGSITDILVTELVNNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLI 1559

  Fly  1679 FLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQPPYC 1741
            .:|.|.||:.|..|||.:...:  .|....||.:....:.:|||..|||.|:.||..|:...| |
Zfish  1560 AILFFIYAIIGMQLFGNLALDDEGAINEHNNFRTFFMALMLLFRSATGEAWHDIMLSCLGGMP-C 1623

  Fly  1742 ---TLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIR 1803
               .:|     ::||: ..:..||.:|..:.::::|||.||:||:||.  |...:.::|....:.
Zfish  1624 EPEEVG-----SECGS-NVAYAYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLD 1680

  Fly  1804 NFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCYELD-KLHNG 1860
            .:...|...|....|.|..:.:..:||::...|    :| |.:   .|||      .:| .:.:.
Zfish  1681 EYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKC-PHRVACKRLL------RMDLPVADD 1738

  Fly  1861 EDVTFHDVINMLSYRSVDIRKA------------LQLEEL-----LAREEFEYLVEEE------- 1901
            ..|.|:..:..|...::||:.|            |:.|.:     |:::..:.||...       
Zfish  1739 NTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLT 1803

  Fly  1902 -----VAKMTIRTWLEGCLKKIRAQNASKQQNSL----------------IAGLRATNEQPV--M 1943
                 .|.|.:..:.:...||::|....:.:..|                :.||....::||  :
Zfish  1804 VGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNSL 1868

  Fly  1944 RPNIQEDKAPLGAVDKSAISTISGAVAGAC------------------------PPTSD--AFSP 1982
            .|.:..:::.         |.::......|                        |.|.:  .|.|
Zfish  1869 PPEVGMNESQ---------SWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTVEMREFGP 1924

  Fly  1983 T---FSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGA--ATATGTSSGLGVGPPTVQSTARH 2042
            .   :|.||...........:.:|..............|:  :|.|.||       |..:||:..
Zfish  1925 VGDGYSDTEPYHPMEGHGRTISMPRLSADNQRRRHRPRGSNLSTITDTS-------PMRRSTSSL 1982

  Fly  2043 VMTVGKRG-----YALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRKK------ 2096
            |.....||     |:|.|   ..|..|.:. ||...|   |....|::|.|.||::...      
Zfish  1983 VHGRSGRGVRLDDYSLER---VVSEEGHRH-APRRRD---RDRDRDRDRSHRTSERSLARYTDAD 2040

  Fly  2097 ----NSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAAALHGYGH 2157
                ..::|...:|.|....::|..|....:.              |:                |
Zfish  2041 TGLGTDLSTTTQSGDLPPKERERERGRAKDRR--------------HH----------------H 2075

  Fly  2158 GHGHGHGGHGGHGGHGEHQMHHH----------------HGGALGSPSAMMSQMIGGSGKLLP 2204
            .|.|.||.........|...|.|                .|...||.|...|.:...||...|
Zfish  2076 HHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGHRQGSSSVSGSPVPSTSGTSTP 2138

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 69/299 (23%)
Ion_trans 734..927 CDD:278921 63/215 (29%)
Ion_trans 1240..1497 CDD:278921 72/281 (26%)
Ion_trans 1571..1793 CDD:278921 59/226 (26%)
cacna1abXP_021335317.1 Ion_trans 91..360 CDD:306908 72/317 (23%)
Ion_trans 465..703 CDD:306908 70/250 (28%)
Ion_trans 1099..1335 CDD:306908 67/253 (26%)
Ion_trans 1425..1672 CDD:306908 63/255 (25%)
GPHH 1673..1743 CDD:318993 15/76 (20%)
Ca_chan_IQ 1745..1820 CDD:312334 11/74 (15%)
Herpes_ICP4_C 1841..>2243 CDD:332854 62/351 (18%)
PAT1 <2144..2300 CDD:330585
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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