DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1ab

DIOPT Version :10

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_073772160.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2463 Species:Danio rerio


Alignment Length:2475 Identity:515/2475 - (20%)
Similarity:885/2475 - (35%) Gaps:645/2475 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 PHPHGHPHSYPHLRHSQPASASQFSFNPSPGSSPGNGLGLGARQDA--ASALNSPTTIVNSGSGS 210
            |...||     .||...|.|.|....|||...:..:......:.|:  .|..|...|:|..|:  
Zfish    18 PLRKGH-----RLRCHPPTSGSSVCANPSYYHTVYDMSDEACQVDSFDYSKTNGGETLVTDGT-- 75

  Fly   211 GGGSSVAFGMQPQQQQQSLAGGGGG------------GSSATAAPSSGGGHNNGAGLGPVV---- 259
                  .:.:.|...........||            .....:.|.:.......|..|..|    
Zfish    76 ------LYSLMPNDSLVPPVRRRGGLVDHRDVIKAHQSHKLQSTPQARRKQWEMARFGDEVPARY 134

  Fly   260 GGGGGGLNLLGGLGGMGGMGGGAAAAGMGICGGISSTVGSAAITGVPPIGLGIATGIGNKIMLGR 324
            ||||||.:..||.|..|...||...|.......::....:.||....|:.       .|.:.:.|
Zfish   135 GGGGGGGSGQGGPGRGGSRQGGPPGAQRMYKQSMAQRARTMAIYNPIPVR-------QNCLTVNR 192

  Fly   325 KQSLKGGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTS---VSLNTPKTFERYPS 386
            ...|...:..:..|.  :.:.|....||   :.:..::..|.:::|..   |...||.: ||...
Zfish   193 SLFLFSEDNIVRKYA--KKITEWPPFEW---MILTTIIANCIVLALEQHLPVGDKTPLS-ERLEE 251

  Fly   387 LQ--FITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEV 449
            .:  ||.         :|..|...|:...|....:..||::.|...|..:|   ...|:..:...
Zfish   252 TEPYFIA---------IFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVV---LTGILSSVGSE 304

  Fly   450 LEIVPKFSYLSIMRAPRPLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSL 511
            |::    ..|..:|..|||.:   |..|:|.|| |:.|:.|..:      || .|.||....|  
Zfish   305 LDL----RTLRAVRVLRPLKLVSGIPSLQVVLK-SIMKAMIPLL------QI-GVLLFVAILM-- 355

  Fly   512 YGLLGVQFF-GELKNHCVMNNTEYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDF 575
            :.::|::|: |:....| .|....::|........:....:|.|     .||...|.        
Zfish   356 FAIIGLEFYMGKFHTTC-FNTITGEMYDERPCGARTCDANNTQC-----QGYWLGPN-------- 406

  Fly   576 LSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSL-PAWRAAFYFSTMI---FFLAWLV 636
                 .|...|:::..::.||:|..:.|||..::|.:.|:| .||...:|...:|   ||:..||
Zfish   407 -----YGITQFDNVLFAVLTVFQCITMEGWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLV 466

  Fly   637 KNVFIAVITE---------TFNEIRVQFQQMWGARGHIQKTA-ASQIL---SGNDTG-WRLVTID 687
            ..|......:         .|.:::.|.|......|:::... |.:::   ..|||| .|..|:.
Zfish   467 LGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILAEDDNDTGSRRRPTLK 531

  Fly   688 DNKHGGLAPE-------------------------------------TCHAILRSPYFRMLVMSV 715
            .||...|.|:                                     ....::::..|...|:|:
Zfish   532 KNKADLLNPQEGVDHMGDSVGSPFARGSMSGKGDETPFSKKERRLRFLIRKMVKTQAFYWTVISL 596

  Fly   716 ILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELL 780
            :..|.:..|.:   |..:| ::..:..||.|.:|..|...|.|.|:|.||.|.|:..|.:.|:..
Zfish   597 VALNTLCVAVV---HYDQP-ELLSDFLYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCA 657

  Fly   781 LAAGTTLHIV-PMFYPS---GLTYFQVLRVVRLIKAS---PMLEGFVYKIFGPGKKLGSLIIFTM 838
            :..|:...:| .|..|.   |::..:.||::|:.|.:   ..|...|..:....|.:.||:....
Zfish   658 VIVGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLF 722

  Fly   839 CLLIISSSISMQLFCFLCDF------TKFESFPEAFMSMFQILTQEAWVEVM----------DET 887
            ..:::.:.:.||||....:|      |.|::||.|.|::|||||.|.|..||          |:.
Zfish   723 LFIVVFALLGMQLFGGQFNFELGTPPTNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKG 787

  Fly   888 MIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLP 952
            ||         .:|:||:..||....:|::|:|:.:|||...:::.|.:|.:  |::...|..|.
Zfish   788 MI---------FSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE--EEATTQKMALQ 841

  Fly   953 FRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVV 1017
            ....:.|..|.|.....:..:.::                .::..|||:: ||........|..|
Zfish   842 KAKEVAEVSPLSAANLSIAAVKSE----------------RIDATDSLLD-CKEQQKNSKGSKSV 889

  Fly  1018 F-RKQKPVRIMNKTAKVRAAGSSL---------------------RKLAITHIINDSNNQRLMLG 1060
            : ::...:|..|......|..:.|                     |.|.:....|.:||......
Zfish   890 WEQRTSEIRRQNLMTSREALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQENRNNNTNKPRP 954

  Fly  1061 D------------------------------------SAMLPVVG-------------------- 1069
            |                                    |..||.:.                    
Zfish   955 DDPNPQERSEEHPSRSHHHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEGAGEHRRPRHH 1019

  Fly  1070 ------------------------TKGG----GGLKSQGTITHSKPWRVD----------QKKFG 1096
                                    |.||    |..|.|....|:.....|          .||.|
Zfish  1020 QHRRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEG 1084

  Fly  1097 SRSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQA--KRQQAEMRRNQR 1159
            |.|..|.::.|....:..|...::|       ..||.:...||.|..|...  ..:||....|.|
Zfish  1085 SLSTARPIQPGLPHTESQYSEDLDN-------LRNSSKMAIHDPDPDLYDPYYDPEQANNLLNLR 1142

  Fly  1160 EEDLRENHPFFDTPLFLVPRESRFRKICQKIVHARYD---------ARLK-------DPLTGKER 1208
            ..||.      |:.|.|..        ..|:.|...|         |:|:       :|....|:
Zfish  1143 GPDLH------DSSLILTD--------SSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEK 1193

  Fly  1209 KVQ----------------------------YKSLHNFLGLVTYLDWVMIFATTLSCISMMFETP 1245
            |.:                            ::...:::..:.|.:..::....:|.|::..|.|
Zfish  1194 KEEEEDDGGDEEGHKRIPPFSSCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIALAAEDP 1258

  Fly  1246 NYRVMD-HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWM 1309
            ..:..: :..|:..:|.|....:.|:.:|::..||.....:|.:|:...|| |: |||.:.:.:.
Zfish  1259 VSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLD-FV-VVSGALVAFA 1321

  Fly  1310 PLNIPTN---SAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASY 1371
            .......   |..:.|.:||.:|||:....:|.::.|...:....|.:|.:..:.:|.|||||..
Zfish  1322 FTGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVV 1386

  Fly  1372 GVQLYGGRLARCNDPTISRREDCVG---VFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFN 1433
            .|||:.||...|.|.:.....||.|   |:.|...|...|               |.| ....|:
Zfish  1387 AVQLFKGRFFYCTDESKEFARDCRGEYLVYERDNEVKSQK---------------REW-KKYDFH 1435

  Fly  1434 FDNIGDAMLTLFEVLSFKGWLDVR----DVLIKAVGP----------VHAVYIHIYIFLGCMIGL 1484
            :||:..|:||||.|.:.:||.||.    |...:..||          .:.||..::.|    ..:
Zfish  1436 YDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVVFPF----FFV 1496

  Fly  1485 TLFVGVVIANYSENKGTAL----LTVDQRRWCDLKKRLKIAQPL--HLPPRPDGRKIRAFTYDIT 1543
            .:||.::|..:.|.....:    |..::|...|....   |:||  |:|     :..::|.|.:.
Zfish  1497 NIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAIN---AKPLTRHMP-----QNKQSFQYRMW 1553

  Fly  1544 QHII---FKRVIAVVVLINSMLLSITWI-KGEVHTERLVIVSAVLTFVFVVEVVMKNIAFTPRGY 1604
            |.::   |:..|..::.:|:::|.:.:. ..:.:.:.|..::.|.|..|.:|.::|.|||..|.:
Zfish  1554 QFVVSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNF 1618

  Fly  1605 WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVC 1669
            ::...|.:|.:..:..:..|::..::.|.::..|..:....|...:..:..|:::|:.|...|..
Zfish  1619 FRDAWNIFDFVSVIGSITDILVTELVNNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFK 1683

  Fly  1670 KSFFIIFGMFLLVFFYALAGTILFGTVKYGE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMH 1732
            ...::...:.:|.|.||:.|..|||.:...:  .|....||.:....:.:|||..|||.|:.||.
Zfish  1684 ALPYVCLLIAILFFIYAIIGMQLFGNLALDDEGAINEHNNFRTFFMALMLLFRSATGEAWHDIML 1748

  Fly  1733 DCMVQPPYC---TLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEED 1794
            .|:...| |   .:|     ::||: ..:..||.:|..:.::::|||.||:||:||.  |...:.
Zfish  1749 SCLGGMP-CEPEEVG-----SECGS-NVAYAYFVSFIFLCSFLMLNLFVAVIMDNFE--YLTRDS 1804

  Fly  1795 ALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCY 1852
            ::|....:..:...|...|....|.|..:.:..:||::...|    :| |.:   .|||      
Zfish  1805 SILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKC-PHRVACKRLL------ 1862

  Fly  1853 ELD-KLHNGEDVTFHDVINMLSYRSVDIRKA------------LQLEEL-----LAREEFEYLVE 1899
            .:| .:.:...|.|:..:..|...::||:.|            |:.|.:     |:::..:.||.
Zfish  1863 RMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVT 1927

  Fly  1900 EE------------VAKMTIRTWLEGCLKKIRAQNASKQQNSL----------------IAGLRA 1936
            ..            .|.|.:..:.:...||::|....:.:..|                :.||..
Zfish  1928 PHKSATDLTVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPE 1992

  Fly  1937 TNEQPV--MRPNIQEDKAPLGAVDKSAISTISGAVAGAC------------------------PP 1975
            ..::||  :.|.:..:::.         |.::......|                        |.
Zfish  1993 LPQEPVNSLPPEVGMNESQ---------SWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQ 2048

  Fly  1976 TSD--AFSPT---FSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPT 2035
            |.:  .|.|.   :|.||...........:.:|.    ::....|...|||.|.||       |.
Zfish  2049 TVEMREFGPVGDGYSDTEPYHPMEGHGRTISMPR----LSADNQSVRSAATITDTS-------PM 2102

  Fly  2036 VQSTARHVMTVGKRG-----YALNRSDSTGSSAGRKFLAPTSSDPQQRSTLSDKERLHITSQQRK 2095
            .:||:..|.....||     |:|.|   ..|..|.:. ||...|   |....|::|.|.||::..
Zfish  2103 RRSTSSLVHGRSGRGVRLDDYSLER---VVSEEGHRH-APRRRD---RDRDRDRDRSHRTSERSL 2160

  Fly  2096 K----------NSMTTLPHAGQLGQLAKQRGGGGEATKSSSFFAQLNSEIGQFHYPTINAAAAAA 2150
            .          ..::|...:|.|....::|..|....:.              |:          
Zfish  2161 ARYTDADTGLGTDLSTTTQSGDLPPKERERERGRAKDRR--------------HH---------- 2201

  Fly  2151 ALHGYGHGHGHGHGGHGGHGGHGEHQMHHH----------------HGGALGSPSAMMSQMIGGS 2199
                  |.|.|.||.........|...|.|                .|...||.|...|.:...|
Zfish  2202 ------HHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGHRQGSSSVSGSPVPSTS 2260

  Fly  2200 GKLLP 2204
            |...|
Zfish  2261 GTSTP 2265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 361..654 CDD:459842 71/314 (23%)
Ion_trans 705..927 CDD:459842 69/244 (28%)
Ion_trans 1224..1497 CDD:459842 75/293 (26%)
Ion_trans 1545..1793 CDD:459842 63/256 (25%)
cacna1abXP_073772160.1 None

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