DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and cacna1eb

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_017206695.2 Gene:cacna1eb / 567702 ZFINID:ZDB-GENE-070705-133 Length:2168 Species:Danio rerio


Alignment Length:2080 Identity:434/2080 - (20%)
Similarity:803/2080 - (38%) Gaps:494/2080 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   350 IEW--VNKLWVRRLMRLCALVSL---------TSVSLNTPKTFERYPSLQFITFASDTAVTLLFT 403
            |||  ...:.:..::..|.::||         |.:|....|| |.|    ||.         :|.
Zfish    68 IEWPPFEYMILATIIANCIVLSLEQHLPGEDKTPMSKRLEKT-EPY----FIG---------IFC 118

  Fly   404 AEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWI--SIILQIFEVLEIVPKFSYLSIMRAPR 466
            .|...|:...|.:..:..||::.|     :::.|:.:  .|:......:.|......|..:|..|
Zfish   119 FEAGIKLVALGFVFHKGSYLRNGW-----NVMDFIVVLSGILATAGSHMNIPVDLRTLRAVRVLR 178

  Fly   467 PLIM---IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHC 527
            ||.:   |..|::.|| |:.|:.:         .:..:.|...|.:.::.::|::|: |:|.:.|
Zfish   179 PLKLVSGIPSLQIVLK-SIIKAMV---------PLLQIGLLLFFAILMFAIIGLEFYSGKLHHTC 233

  Fly   528 VMNNTEYDLYKRPILTINSLAIPDTFCSMD--PDSGYQCSPGMVCMKMDFLSSYV---IGFNGFE 587
            :   .:.|:....  |::|..: |..|.:.  ||. |.||           .|::   .|...|:
Zfish   234 L---ADLDILDNE--TVDSSEV-DFACGVRKCPDK-YTCS-----------GSWIGPNDGITQFD 280

  Fly   588 DIATSIFTVYQAASQEGWVFIMYRAIDSL-PAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEI 651
            :|..::.||:|..:.|||..::|...|:| |.|. ..||..:|...::.|.|:.:.|::..|.:.
Zfish   281 NILFAVLTVFQCITMEGWTAVLYNTNDALGPTWN-WIYFIPLIIIGSFFVLNLVLGVLSGEFAKE 344

  Fly   652 RVQFQQMWGARGHIQKTAASQILSGNDTGWR--------LVTIDDNKH----------------- 691
            |.:.:.    |....|....|.:.....|:|        ::..::||:                 
Zfish   345 RERVEN----RRAFMKLRRQQQVERELNGYRAWIDRAEEVMLQEENKNSGRSALDVLKRATSKKN 405

  Fly   692 ------------------GGLAPE-----------------------TCHAILRSPYFRMLVMSV 715
                              ||..|.                       :...::::..|..:|:|:
Zfish   406 ARRRGPGEEKYSEISTVAGGSRPRVGMRTPRRGPAAYLRRKERMLRFSIRRMVKTDSFYWIVLSL 470

  Fly   716 ILANGIVTATMTFKHDGRPRDVFYERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELL 780
            :..|   |.:::..|..:|..:...: ||.|.||..|...|...|:|.||:|.|:..|.:.|:..
Zfish   471 VALN---TISVSIVHHNQPEWLTVIQ-YYTEFVFLGLFLAEMFLKMYGLGFRLYFHSSFNCFDCG 531

  Fly   781 LAAGTTLHIVPMFYPSGLTY-FQVLRVVRLIKASPM------LEGFVYKIFGPGKKLGSLIIFTM 838
            :..|:...:|..|:..|::: ..|||.:||::...:      |...|..:....|.:.||:....
Zfish   532 VIVGSIFEVVWGFFRPGVSFGISVLRALRLLRIFKITKYWSSLRNLVVSLMSSMKSIISLLFLLF 596

  Fly   839 CLLIISSSISMQLF---CFLCDF--TKFESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTL--T 896
            ..:::.:.:.||||   ....|:  |.|::||.:.|::|||||.|.|.||| ...||:...:  .
Zfish   597 LFIVVFALLGMQLFGGRFIFEDYTPTNFDTFPASIMTVFQILTGEDWNEVM-YNGIRSQGGVHYG 660

  Fly   897 PLVAVYFILYHLFVTLIVLSLFVAVILDNLELDEDIKKLKQ----------LKFREQSAEIKETL 951
            ...::|||:..||....:|::|:|:.:|||...:::.|.::          .|.||.....:...
Zfish   661 MWSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKEEEEEEEEFFNQRYKSREFGLSERRRR 725

  Fly   952 P--FRLRIFEKFPDSP-------------------------------QMTILHRIPNDFMLPKVR 983
            |  :|.|...:...||                               .|::..:..|  .|.|.|
Zfish   726 PYLYRKRAIHRGRPSPAEAEEEAAGKQAAEEQPVNAFAGRRERRKKINMSVWEQRAN--QLRKRR 788

  Fly   984 ESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKV--------------- 1033
            :...:..:....|||.     ..|.|:..:.:.:..:..|:.:......|               
Zfish   789 QMASREVLFGGPTEDQ-----DTPGSDHHQQHSLSTETSPLHLPESPMSVGMPLPEPPMSITIPL 848

  Fly  1034 -------RAAGSSL--RKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWR 1089
                   ..:||.|  |..|..|..|.....|:.....| ....|...||..|..   .|.:...
Zfish   849 PEPPESEPLSGSGLEERPSANNHHANTERRHRVARKFRA-AAAAGVAEGGRHKRH---RHRESRT 909

  Fly  1090 VDQKKFGSRSIRRSVRSGSIKLKQTY-EHLM---------ENG---------DIAAAPRANSGRA 1135
            ..:.....:...|....|..|.::.. :|:|         ||.         |:....:|:..:.
Zfish   910 EARNAENHQQFERQAEDGEGKTEEAQSKHMMNMCDPERQIENQEECQREFVCDLTGLSQASGHQE 974

  Fly  1136 RPHDLDIKLLQAKRQQAEMRRNQRE-----------EDLRENHPFF-------DTPLFLVPRESR 1182
            ..        ||:.|:|::.|::.:           .|:..|..:.       :|.|   .|||.
Zfish   975 ED--------QAESQEAQLLRHKEDFSTESKYMTEVSDIENNGSYLNQDECMTETSL---KRESS 1028

  Fly  1183 FRKICQ--------KIVHARY--------------DARLKDPLTGKERKVQ-----------YKS 1214
            .:.:.:        |.|.|..              |...:|...|.|:...           :||
Zfish  1029 SQPLLEMAPMTVSFKDVEASLSDKADDDDDDDMDDDDDYEDDENGGEKSTASKPERPDSMFIFKS 1093

  Fly  1215 ------LHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMD-HPTLQIAEYGFVIFMSLELAL 1272
                  :.:::..:.|.:..::.....|.|::..|.|.....: :..|:..:|.|....:.|:.:
Zfish  1094 KNPIRRICHYVVTLRYFEMTILLVIVASSIALAAEDPVCTSSERNKVLRYFDYVFTGVFTFEMII 1158

  Fly  1273 KILADGLFFTPKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNS------AAQLLMILRCVRPL 1331
            |::..||.....:|.:|:...|| ||.||. :.:.:...|:..|:      ..:.|.:||.:|||
Zfish  1159 KMIDQGLILHDGSYFRDMWNILD-FIVVVG-ALIAFALTNLLGNNKGRDIKTIKSLRVLRVLRPL 1221

  Fly  1332 RIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCNDPTISRREDCVG 1396
            :....:|.::.|...:....|.:..:..:..|.|||||...|||:.|:...|.|.::..:::|.|
Zfish  1222 KTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDGSMGTQKECQG 1286

  Fly  1397 VFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVR---- 1457
            .:          :..|.|..   .:..|.|.. ..|::||:..|:||||.|.:.:||..|.    
Zfish  1287 YY----------IDYGRDRK---EVKKREWRR-HEFHYDNVLWALLTLFTVSTGEGWPQVLQHSV 1337

  Fly  1458 DVLIKAVGPVH------AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTALLTVDQRRWCDLKK 1516
            ||..:..||..      :::..||..:.....:.:||.::|..:.| :|..::     ..|:|:|
Zfish  1338 DVTEEDHGPSRGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQE-QGDKMM-----EECNLEK 1396

  Fly  1517 RLKI-------AQPL--HLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEV 1572
            ..:.       |:||  ::|......:.|.:.:.::..  |:..:.|::.:|:::|.:.:.....
Zfish  1397 NERACIDFAISAKPLTRYMPQNRQTLQYRLWHFVVSPS--FEYTVLVMIALNTVVLMMKYYSAPT 1459

  Fly  1573 HTERLVI--VSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWII--LQTILRND 1633
            ..: :|:  ::...|.:|.:|.::|.:||....|::...|.:|.:..:..:..|:  ||::...:
Zfish  1460 AYD-IVLKHLNTAFTVLFSLECILKIMAFGFMNYFRDTWNIFDFITVLGSITEIVVDLQSVNTIN 1523

  Fly  1634 LSYFFGFMVVILRFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKY 1698
            :|:...|...  |...:..:..|:::|:.|...|.....::...:.:|.|.||:.|..:||.:|.
Zfish  1524 MSFLKLFRAA--RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1586

  Fly  1699 GE--GIGRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCM----------VQPPYCTLGNNYWETD 1751
            .:  .|.:..||.:....:.:|||..|||.|.:||..|:          :.||:.:..:   |..
Zfish  1587 NDESHINQHNNFKTFFGALMLLFRSATGESWQEIMLSCLEGKECEPDPSITPPFTSPDH---EGG 1648

  Fly  1752 CGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQ 1816
            ||...| ..||.:|....::::|||.||:||:||.  |...:.::|....:..|...|...|...
Zfish  1649 CGTDFA-YFYFVSFIFFSSFLMLNLFVAVIMDNFE--YLTRDSSILGPHHLDEFVRIWGEYDRAA 1710

  Fly  1817 RGVIPVRRVKFILRLLKGRL----ECDPQK---DRLLFKYMCYELDKLHNGEDVTFHDVINMLSY 1874
            .|.|....:..:|..:...|    :| |.|   .||:...|..:       ||:|.|....::|.
Zfish  1711 CGRIHYNAMYEMLTHMSPPLGLGKKC-PAKIAYKRLVLMNMPVD-------EDMTVHFTSTLMSL 1767

  Fly  1875 RSVDIRKALQLEELLAR-EEFEYLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATN 1938
                ||.||:::  :|| .|....::.|:.|.....|          .:.|::...|:..:....
Zfish  1768 ----IRTALEIK--IARGGEDRLQLDMELQKEISFIW----------PHLSQKTLDLLVPINKDT 1816

  Fly  1939 EQPV--------------------MRPNIQEDK-APLGAVDKSAISTI-SGAVAGACP--PTSDA 1979
            :..|                    :|..::..: |.|..:..||.|.: ||......|  |....
Zfish  1817 DMTVGKIYASRMIMDFFKQSKAKKLRLQVEAQRAAALPLISHSAGSALTSGGFVALSPISPQELL 1881

  Fly  1980 FSPTFSSTENEEKDGSSSAVVQLPHSETSIAGTGSSATGAATATGTSSGLGVGPPTVQSTARHVM 2044
            ..|....|::.| |..:|.|     .|:.:.|......               ||.....|||  
Zfish  1882 LQPITQRTDSSE-DYDASQV-----DESGLNGVWGEDR---------------PPEHAFRARH-- 1923

  Fly  2045 TVGKRGY--ALNRSDST--------GSSAGRKFLAPTSSDPQQRSTLSDKERLH-ITSQQRKKNS 2098
                :.|  |::.|:.|        .....|..|:|.:|:.:.||....:||:| :|.|.....|
Zfish  1924 ----KSYKAAVSHSEQTQYMEKVRGRPKEQRLLLSPKNSNSKSRSRSPSEERVHGVTRQGNSSES 1984

  Fly  2099  2098
            Zfish  1985  1984

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 68/292 (23%)
Ion_trans 734..927 CDD:278921 62/206 (30%)
Ion_trans 1240..1497 CDD:278921 67/273 (25%)
Ion_trans 1571..1793 CDD:278921 60/237 (25%)
cacna1ebXP_017206695.2 Ion_trans 70..349 CDD:306908 73/326 (22%)
Ion_trans 463..698 CDD:306908 69/239 (29%)
Ion_trans 1108..1387 CDD:306908 72/295 (24%)
Ion_trans 1432..1689 CDD:306908 64/267 (24%)
GPHH 1690..1760 CDD:318993 17/77 (22%)
Ca_chan_IQ 1762..1836 CDD:312334 14/89 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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