DRSC/TRiP Functional Genomics Resources

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Protein Alignment na and scn5lab

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:NP_001038588.1 Gene:scn5lab / 566868 ZFINID:ZDB-GENE-060908-3 Length:1954 Species:Danio rerio


Alignment Length:2029 Identity:400/2029 - (19%)
Similarity:729/2029 - (35%) Gaps:625/2029 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   361 LMRLCA-LVSLTSVSLNTPKTFERYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLK 424
            |..:|. |.:...::::.|..:.:|....|         |.::|.|.:.|:..||...|...:|:
Zfish   133 LFIMCTILTNCCFMAMSEPAQWAKYVEYTF---------TGIYTFESLIKILARGFCIGPFTFLR 188

  Fly   425 DHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQ 489
            |.|        ::|..|:||..:     |.:|..|..:.|.|...::|.|:........|:.:..
Zfish   189 DPW--------NWLDFSVILMAY-----VTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

  Fly   490 IFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVMN-----NTEYDLYKRPILTINSLA 548
            :. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:..||.:     ||....|.......|:.:
Zfish   241 LI-QSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKCVRSASQCLNTTLPTYNNSTFICNNRS 304

  Fly   549 ---------IPDTF-----------CSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSI 593
                     ..|.|           |....|:| :|..|..|:|.....:|  |:..|:....:.
Zfish   305 WASLEEFFNNEDNFFKVEGAKDALICGNASDAG-KCPDGFECLKTGRNPNY--GYTSFDTFGWAF 366

  Fly   594 FTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFL-AWLVKNVFIAVITETF--------- 648
            .::::..:|:.|..:.:..:.|  |.:|...|..::.|| ::.:.|:.:||:...:         
Zfish   367 LSLFRLMTQDYWENLYHHTLRS--AGKAYMVFFVVVIFLGSFYLVNLILAVVAMAYEEQNQATIA 429

  Fly   649 ------NEIRVQFQQM------------------------------------------------- 658
                  .|.::..:|:                                                 
Zfish   430 EALQKEQEFQLAMEQLKKEQQAAQKAQETESILTADVSPFSTQDKAKLERRKSSRPLSEGTGEDK 494

  Fly   659 ----------------------------------------------------------------- 658
                                                                             
Zfish   495 PAKLDPIEGIKQTHSLLVRTLSLRARRESAVSIFNFRPVNKDSELDFADDEFSNHGDSDSRGGAL 559

  Fly   659 ---WGARGHIQKTAA-------SQIL--SGNDTGWRLVTIDDN---KHGGLAPET---------- 698
               |..|    :|:|       ||..  |.|..|..:|.::.|   ..|.|.|.|          
Zfish   560 ALPWSRR----RTSAQSSCSHSSQFFFPSFNINGKLMVAVEQNGISSQGPLTPMTPLTPLPACTM 620

  Fly   699 ---------------------------------------------------CH------------ 700
                                                               ||            
Zfish   621 EKLKEESGQNSSNELSSMLLPQLPPEGRDRALSATSYITDAMEELEEAQQKCHPCWYVFAHKYLV 685

  Fly   701 ---------------AILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI-ELVF 749
                           .::..|:..:.:...|:.|   |..|..:|  .|....:.|...: .|||
Zfish   686 WTCSPRWLKVKEWVKIMVMDPFLDLAITICIVLN---TLFMALEH--YPMTDEFNRMLSVGNLVF 745

  Fly   750 TCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPSGLTY---FQVLRVVRLIK 811
            |.:...|.:.||..|....|::...:.|:.|:.: .:|..:.:....||:.   |::|||.:|.|
Zfish   746 TGIFTAEMVLKIIALDPYYYFQQGWNIFDSLIVS-LSLMELGLSNVEGLSVLRSFRLLRVFKLAK 809

  Fly   812 ASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF------CFLCDFTK--------F 861
            :.|.|...: ||.|.. ..||:|.:....::.|.:.:.||||      | :|..:|        .
Zfish   810 SWPTLNTLI-KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYDLC-VCKISKDCTLPRWHM 872

  Fly   862 ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL--- 923
            :.|..:|:.:|::|..| |:|.|.:.|....:   ||..:.|:|..:...|:||:||:|::|   
Zfish   873 KDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ---PLCILVFMLVMVIGNLVVLNLFLALLLSSF 933

  Fly   924 --DNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESF 986
              |||...::..::..|:.                            .:.||....:.       
Zfish   934 SADNLSAPDEDGEMNNLQI----------------------------AIARIQRGMLW------- 963

  Fly   987 MKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIIND 1051
                             .::.:.:.:..|...|:||        ||...|...|::|        
Zfish   964 -----------------LRQALCDFFNGNFKRRRQK--------AKEAKAMLKLKRL-------- 995

  Fly  1052 SNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKL---KQ 1113
            :.......|:.....:..:.|.|..:....:|:.           :.:|...:..|...:   ::
Zfish   996 TQQAHWAEGNGTAGVIERSSGAGSGEDDSYMTNP-----------NLTISVPIAPGESDVEFPEE 1049

  Fly  1114 TYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLRENHPFFDTPLFLVP 1178
            ..|...|..:.:|:........:|.| |..|  ::....::|:...|||     .:.:.....:.
Zfish  1050 EDEEEDEEEEASASSDEEPEPCKPRD-DTSL--SEGSTIDLRKPGEEED-----EYSEMAEEAMD 1106

  Fly  1179 RESRFRKICQKIVHAR-YDARLKDPLTGKE----RKVQYKSLHNFLGLVTYLDWVMIFATTLSCI 1238
            .|:.|..:|  :.|.: .|....:.| |:.    ||..|:.:.:     ::.:..:||...||..
Zfish  1107 PENCFPDVC--VRHFKCCDINTSEGL-GRAWWRLRKTCYQIVEH-----SWFETFIIFMILLSSG 1163

  Fly  1239 SMMFET--PNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVV 1301
            ::.||.  .:.|.:....|:.|:..|.....||::||.:|.|.    :.|..:....||..|..|
Zfish  1164 ALAFEDIYIDQRKVVKVILEYADKIFTYIFILEMSLKWIAYGF----RKYFTNYWCWLDFLIVDV 1224

  Fly  1302 STSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMF 1366
            |...|....|.....:|.:.|..||.:||||..:....||.||..|......|:.|..:.::...
Zfish  1225 SLVSLVANTLGYSDFAAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWL 1289

  Fly  1367 IFASYGVQLYGGRLARC--------NDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVP 1423
            ||:..||.|:.|:..||        |...|:.|.:|:.:...:.:.||:|:              
Zfish  1290 IFSIMGVNLFAGKFGRCVNRTGFIYNSSDINNRSECLEMNSTQYYWTKVKV-------------- 1340

  Fly  1424 RVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLI--KAV--GPV--HAVYIHIY----IFL 1478
                     ||||:|...|.|.:|.:||||:::....:  :||  .|:  :::|:::|    |..
Zfish  1341 ---------NFDNVGAGYLALLQVATFKGWMEIMYAAVDSRAVEEQPIKENSLYMYLYFVIFIIF 1396

  Fly  1479 GCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRL---KIAQPLHLPPRPDGRKI 1535
            |....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|   |..:|:..||.|    :
Zfish  1397 GSFFTLNLFIGVIIDNFNQQKRKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNP----V 1457

  Fly  1536 RAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLV-IVSAVLTFVFVVEVVMKNIAF 1599
            :.|.:|:.....|..:|.:::::|.:.:.:...:.....:.:: .::.|...:|..|.::|.||.
Zfish  1458 QGFFFDLVSKQAFDILIMLLIILNMVTMMVETDEQSPSIKHILDCINLVFIVIFTSECILKIIAL 1522

  Fly  1600 TPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITG 1652
              |.|     |    |.:|.:|.:..::.|:|..|:.   .||..   |.|:.|    |...:..
Zfish  1523 --RCYFFTVSW----NIFDFVVVILSIVGIVLADIIE---KYFVSPTLFRVIRLARIGRILRLIR 1578

  Fly  1653 KHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAM 1717
            ....::.|:..:.:|:...|.|...:||::|.||:.|...|..||...||....||.:....:..
Zfish  1579 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQGGIDDMFNFETFGNSMIC 1643

  Fly  1718 LFRIVTGEDWNKIMHDCMVQPP-YCT-----LGNNYWETDCGNFTASLIYFCTFYVIITYIVLNL 1776
            ||:|.|...|:.::...:..|| .|.     .|.|. ..:||..:..:.:|.|:.:|...||:|:
Zfish  1644 LFQITTSAGWDNLLSPILNTPPEECDPEIPHTGTNA-RGNCGKPSVGITFFVTYIIISFLIVVNM 1707

  Fly  1777 LVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVI--------------PVR---- 1823
            .:|||:||||: .:.|....||..|...|...|...|......|              |:|    
Zfish  1708 YIAIILENFSV-ATEESTEPLSEDDFEMFYEVWEKFDPEATQFIEYLKLSDFADTLSEPLRIGKP 1771

  Fly  1824 -RVKFI---LRLLKG-RLEC------------------DPQKDRLLFKYMCYELDKLHNGEDVTF 1865
             ::|.|   |.::.| ::.|                  |..|.::..|:|      :.|...:::
Zfish  1772 NKIKLISMDLPMVSGDKIHCLDILFAFTKRVLGESGEMDALKQQMEEKFM------MANPSKISY 1830

  Fly  1866 HDVINML--------------SYRSVDIRKALQLEELLAREEFEYLVEEEVAKMTIRTWLEGCLK 1916
            ..:...|              |||...||:.|:...||.|:            ||:.       .
Zfish  1831 EPITTTLRRKQEEVSAIMIQRSYRRHLIRRQLKQASLLYRQ------------MTMP-------D 1876

  Fly  1917 KIRAQNASKQQNSLIAGLRATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPPTSD--- 1978
            ..:|.::|.:...||..:            |.|:.|....:..||.|:         ||:.|   
Zfish  1877 ADKAGDSSPESQGLIVSM------------IMENYATEAEITISATSS---------PPSYDSVT 1920

  Fly  1979 -AFSPTFSSTENEE 1991
             |.|..|.:...||
Zfish  1921 RATSEIFHALIPEE 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 65/322 (20%)
Ion_trans 734..927 CDD:278921 60/216 (28%)
Ion_trans 1240..1497 CDD:278921 76/276 (28%)
Ion_trans 1571..1793 CDD:278921 63/240 (26%)
scn5labNP_001038588.1 Ion_trans 154..427 CDD:278921 63/300 (21%)
Na_trans_cytopl 478..566 CDD:288761 1/87 (1%)
Ion_trans 723..918 CDD:278921 53/203 (26%)
Na_trans_assoc 944..1143 CDD:284034 38/288 (13%)
Ion_trans 1165..1419 CDD:278921 77/280 (28%)
Na_channel_gate 1411..1463 CDD:240441 12/55 (22%)
Ion_trans 1485..1723 CDD:278921 63/248 (25%)
GPHH 1735..1790 CDD:293510 10/54 (19%)
IQ 1841..1863 CDD:197470 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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