DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment na and scn4ab

DIOPT Version :9

Sequence 1:NP_001096981.2 Gene:na / 45338 FlyBaseID:FBgn0002917 Length:2233 Species:Drosophila melanogaster
Sequence 2:XP_005171642.1 Gene:scn4ab / 564977 ZFINID:ZDB-GENE-051201-1 Length:1835 Species:Danio rerio


Alignment Length:1913 Identity:404/1913 - (21%)
Similarity:699/1913 - (36%) Gaps:547/1913 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 IMLGRKQSLK--GGEPFLADYGPEESLNESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFE 382
            |::.:|.::.  ..||......|...:..:|....::.|:...:| |..|.:...::::.|..:.
Zfish   145 IVIDKKNTIYRFNTEPACYCLSPFNPVRRAAIRILIHSLFSLVIM-LTILTNCVFMAMSDPPGWS 208

  Fly   383 RYPSLQFITFASDTAVTLLFTAEMIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIF 447
            :.  |:::       .|.::|.|.:.|:..||...|:..:|:|.|...|..::|..:::      
Zfish   209 KI--LEYV-------FTGIYTFEAMVKVLSRGFCIGDFTFLRDPWNWLDFMVISMAYLT------ 258

  Fly   448 EVLEIVPKFSYLSIMRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLY 512
                   :|..|..:.|.|...::|.|:........|:.:..:. :|.:::.:|.:..:|.:|::
Zfish   259 -------EFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI-QSVKKLADVMILTVFCLSVF 315

  Fly   513 GLLGVQ-FFGELKNHCVM-------------------------NNTEYDLYKRPILTINSLAIPD 551
            .|:|:| |.|.|:..||:                         .|:.:|..|......|...:|.
Zfish   316 ALIGLQLFMGNLRQKCVLWPPVGWYSDNLTVLSNYTDINGNGTANSTFDYQKYINSEENYYYVPG 380

  Fly   552 TFCSMDP-------DSGYQCSPGMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIM 609
               .|||       |:|. |..|.:|:|.....:|  |:..:::...:...:::..:|:.|..:.
Zfish   381 ---QMDPLVCGNSSDAGL-CPEGYICLKAGRNPNY--GYTSYDNFGWAFLALFRLMTQDFWENLF 439

  Fly   610 YRAIDSLPAWRAA-----FYFSTMIFFLAWLVKNVFIAVIT------------------ETFNEI 651
            ...:      |||     .:|..:||..::.:.|:.:||:.                  |.:.:|
Zfish   440 QLTL------RAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATAAEAKEKEEEYAKI 498

  Fly   652 RVQFQ--------------------------QMW---------------GARGHI---------- 665
            ..|.:                          ||.               |::|:|          
Zfish   499 MEQLKKQAEQKNGMVNGSKTSLSSKKKGDNDQMQSDYDGIALKPLSKSNGSKGNINYLEVPDSQI 563

  Fly   666 -QKTAASQILSGNDT----------GW--------------------RLVTIDDNKHGGLAPETC 699
             :.:..|.:.|..|.          ||                    |:|               
Zfish   564 RKPSVVSAVESALDAQEDIERPCPPGWYKFADIFLKWDCCIPWVKFKRIV--------------- 613

  Fly   700 HAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYYI-ELVFTCLLDLETLFKIYC 763
            :..:..|:..:.:...|:.|   |..|..:|  .|..|..|....| .||||.:...|.:.|:..
Zfish   614 YLFVMDPFVDLGITLCIVLN---TVFMAMEH--YPMSVHVEEVLAIGNLVFTGIFAAEMVLKLIA 673

  Fly   764 LGWRGYYKHSIHKFELLLAAGTTLHIVPMFYP-----SGLTYFQVLRVVRLIKASPMLEGFVYKI 823
            |....|::...:.|:.::   .|:.:|.:...     |.|..|:::||.:|.|:.|.| ..:.||
Zfish   674 LDPYYYFQVGWNIFDSII---VTMSLVELMLADVEGLSVLRSFRLMRVFKLAKSWPTL-NMLIKI 734

  Fly   824 FGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL---CDFTKFE--SFPEAFMSMFQI 874
            .|.. ..||:|.:....::.|.:.:.||||        |.:   |:..::.  .|..||:.:|::
Zfish   735 IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYTDSVCKISSDCELPRWHMADFFHAFLIIFRV 799

  Fly   875 LTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVLSLFVAVIL-----DNLELDEDIKK 934
            |..| |:|.|.:.|....:.:..:|   |::..:...|:||:||:|::|     |||...:|   
Zfish   800 LCGE-WIETMWDCMEVAGQGMCIIV---FMMVMVIGNLVVLNLFLALLLSSFSGDNLSASDD--- 857

  Fly   935 LKQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILHRIPNDFMLPKVRESFMKHFVIELETEDS 999
                 ..|.:.:|                     .:.||....       .::|.||      :.
Zfish   858 -----DGENNLQI---------------------AISRITRGI-------DWIKAFV------NK 883

  Fly  1000 LVENC--KRPMSECWESNVVFRKQKPVRIMNKTAKVRAAGSSLRKLAITHIINDSNNQRLMLGDS 1062
            .|..|  .:|..|                   .|||...|             |:....:|...|
Zfish   884 HVRQCLNLKPKEE-------------------GAKVNGEG-------------DAKMNAIMNSSS 916

  Fly  1063 AMLPVVGTKG------GGGLKSQGTITHSKPWRVDQKKFGSRSIRRSVRSGSIKLKQTYEHLMEN 1121
            :|:.|....|      |.|...            |:...|.          .|.:|:      :|
Zfish   917 SMVKVPIANGESDDDDGNGSSE------------DEDDEGR----------DINMKK------KN 953

  Fly  1122 GDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDL-------REN----HPFFDTPLF 1175
            ||       .|......|        |..:.|....:.||||       .||    .|..|..:.
Zfish   954 GD-------ESSTCSTVD--------KPPEVEDLVEEEEEDLTSPEDCYTENCIRRCPCLDLDVS 1003

  Fly  1176 LVPRES--RFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIFATTLSCI 1238
            ....::  .|||.|..||.                       |      :|.:..:||...||..
Zfish  1004 QGKGKAWWNFRKTCFAIVE-----------------------H------SYFETFIIFMILLSSG 1039

  Fly  1239 SMMFET--PNYRVMDHPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDVAAALDVFIYVV 1301
            ::.||.  ...|.|....|:.|:..|.....:|:.||.:|.|.    |.|..:....||..|..|
Zfish  1040 ALAFEDIYIEQRRMIKIILEYADQVFTYVFVVEMLLKWVAYGF----KVYFTNAWCWLDFLIVDV 1100

  Fly  1302 STSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFKEILLVSTLLILLMF 1366
            |...|....|......|.:.|..||.:||||..:....||.||..|......|..|..:.::...
Zfish  1101 SLISLTANILGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWL 1165

  Fly  1367 IFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLV 1422
            ||:..||.|:.|:...|.:.|         ::.:.||..:.                |.:|.:. 
Zfish  1166 IFSIMGVNLFAGKFYYCFNETSEEVFDHNVVNNKTDCYELM----------------EFHPEVR- 1213

  Fly  1423 PRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDVRDVLIKAVG-------PVHA------VYIHI 1474
               |.| .:.||||:|...|.|.:|.:||||:   |::..||.       ||:.      :|..|
Zfish  1214 ---WMN-GKINFDNVGMGYLALLQVATFKGWM---DIMYSAVDSRAIESQPVYEANLYMYIYFVI 1271

  Fly  1475 YIFLGCMIGLTLFVGVVIANYSENK----GTAL-LTVDQRRWCDLKKRLKIAQPLHLPPRPDGRK 1534
            :|..|....|.||:||:|.|:::.|    ||.: :|.:|:::.:..|:|...:|....|||. ..
Zfish  1272 FIIFGSFFTLNLFIGVIIDNFNQQKAKLGGTDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPT-NC 1335

  Fly  1535 IRAFTYDITQHIIFKRVIAVVVLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVV----EVVMK 1595
            .:...:|......|...|.|::.:|.:.:.:.........|.::.   .:.|.|::    |.|:|
Zfish  1336 CQGLVFDFVTQQFFDIFIMVMICLNMVTMMVETDDQSAEIEEILF---YINFAFIILFTGECVLK 1397

  Fly  1596 NIAFTPRGYWQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FMVVIL----RFFTITGK 1653
            ..|.... |:....|.:|.:|.:..::.|.|..::.   .||..   |.|:.|    |...:...
Zfish  1398 ITALRYH-YFSIGWNIFDFVVVILSILGIGLADLIE---KYFVSPTLFRVIRLARIGRVLRLIRG 1458

  Fly  1654 HTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAML 1718
            ...::.|:..:.:|:...|.|...:||::|.:::.|...|..||...||....||.:....:..:
Zfish  1459 AKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEVGIDDMMNFETFGNSIICM 1523

  Fly  1719 FRIVTGEDWNKIMHDCMVQPPYC----------TLGNNYWETDCGNFTASLIYFCTFYVIITYIV 1773
            |.|.|...|:.::...:..||.|          |.||      |||....:::||::.|:...:|
Zfish  1524 FMITTSAGWDGLLAPILNSPPDCDPDVDNPGSTTRGN------CGNAAVGIVFFCSYIVMSFLVV 1582

  Fly  1774 LNLLVAIIMENFSLFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLEC 1838
            :|:.:|||:|||::......|.|.. .|...|..||...|......|...|:...         |
Zfish  1583 VNMYIAIILENFNVATEESSDPLCE-DDFEMFYETWEKFDPTASQFIDYNRLSEF---------C 1637

  Fly  1839 DPQKDRL------LFKYMCYEL-----DKLH--------NGEDVTFHDVINMLSYRSVDIRKALQ 1884
            |..||.|      ..|.:..::     ||:|        .||.:...|        .:|..||..
Zfish  1638 DTLKDPLRIPKPNTLKLITMDIPMVTGDKIHCLDLLLALTGEVLGGSD--------QMDGMKATM 1694

  Fly  1885 LEELLA----REEFEYLV------EEEVAKMTI-RTW----LEGCLKK----IRAQNASKQQNSL 1930
            .|:.:|    :..:|.:.      :||||..|| |.:    |:.|:|:    .|.:..||:....
Zfish  1695 EEKFMANNPSKASYEPITSTLKRKQEEVAASTIQRAYRSHILKRCVKQASYMYRDKTGSKKPTGE 1759

  Fly  1931 I---AGLRATNEQPVMRPNIQEDKAPLG 1955
            .   .|:.|.|.:.:......||..|:|
Zfish  1760 APEKVGMIAENMRSLYGDQAVEDDHPVG 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
naNP_001096981.2 Ion_trans 373..654 CDD:278921 62/336 (18%)
Ion_trans 734..927 CDD:278921 58/217 (27%)
Ion_trans 1240..1497 CDD:278921 78/280 (28%)
Ion_trans 1571..1793 CDD:278921 58/242 (24%)
scn4abXP_005171642.1 Ion_trans 199..481 CDD:278921 60/316 (19%)
Ion_trans 637..832 CDD:278921 51/204 (25%)
Na_trans_assoc 858..1018 CDD:284034 45/268 (17%)
Ion_trans 1041..1298 CDD:278921 79/284 (28%)
Na_channel_gate 1290..1342 CDD:240441 12/52 (23%)
Ion_trans 1364..1602 CDD:278921 58/250 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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